scholarly journals Cellular and plasma fibronectin in the aqueous humour of primary open-angle glaucoma, exfoliative glaucoma and cataract patients

Eye ◽  
1998 ◽  
Vol 12 (5) ◽  
pp. 886-890 ◽  
Author(s):  
Minna Vesaluoma ◽  
Päivi Mertaniemi ◽  
Sari Mannonen ◽  
Ilkka Lehto ◽  
Risto Uusitalo ◽  
...  
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Plasma Fibronectin ◽  
Exfoliative Glaucoma ◽  
Cataract Patients

Plasma levels of sirtuin and adiponectin in patients with primary open-angle glaucoma, exfoliative glaucoma, and healthy controls

2021 ◽  
pp. 112067212110652
Author(s):  
Aysun Yucel Gencoglu ◽  
Murat Irkec ◽  
Sibel Kocabeyoglu ◽  
Z. Gunnur Dikmen ◽  
Jale Karakaya ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Healthy Controls ◽  
Plasma Samples ◽  
Open Angle ◽  
Control Subjects ◽  
Healthy Control ◽  
Exfoliative Glaucoma ◽  
Chi Square Analysis

Purpose To compare plasma levels of sirtuin 1 (SIRT1) and adiponectin (APN) in patients with primary open-angle glaucoma (POAG), exfoliative glaucoma (XFG), and healthy control subjects. Methods This prospective case-control study collected plasma samples from 118 participants. All subjects underwent a comprehensive ophthalmologic examination before the acquisition of a plasma sample. Plasma samples were obtained from 40 POAG, 38 XFG, and 40 healthy control subjects without any evidence of systemic or ocular disease. Serum SIRT1 and APN levels were estimated by an enzyme-linked immunosorbent assay, ELISA (Elabscience, Houston, USA) method. Statistical analysis of results relied on Kolmogorov-Smirnov, Kruskal-Wallis, Chi-square, analysis of variance (ANOVA) tests, and linear regression analysis, where appropriate. Results A significant decrease in SIRT1 levels was observed in POAG patients compared to healthy controls (p = 0.004, Dunn's test). In contrast, no difference was detected between XFG and POAG patients or healthy controls (p = 0.32 and p = 0.34, respectively, Dunn's test). There was no significant difference in plasma APN levels between the three groups under investigation (p = 0.59, ANOVA). Conclusion Alterations in serum level of SIRT1 may suggest a possible role in POAG via potential effects in neuroprotection and oxidative stress.

scholarly journals Comparison of ocular response analyzer parameters in primary open angle glaucoma and exfoliative glaucoma patients

2014 ◽  
Vol 62 (7) ◽  
pp. 782 ◽  
Author(s):  
Emrullah Beyazyıldız ◽  
HasanBasri Arifoılu ◽  
AyşegülKoçak Altıntaş ◽  
özlem Beyazyıldız ◽  
ͺükrüGültekin Köklü
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Ocular Response Analyzer ◽  
Open Angle ◽  
Exfoliative Glaucoma

scholarly journals Tear and aqueous humour cytokine profile in primary open‐angle glaucoma

2020 ◽  
Vol 98 (6) ◽  
Author(s):  
Barbara Burgos‐Blasco ◽  
Beatriz Vidal‐Villegas ◽  
Federico Saenz‐Frances ◽  
Laura Morales‐Fernandez ◽  
Lucia Perucho‐Gonzalez ◽  
...  
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Cytokine Profile ◽  
Open Angle

Retinal Nerve Fiber Layer Thickness in Patients with Exfoliation, Exfoliative Glaucoma, and Primary Open Angle Glaucoma

2010 ◽  
Vol 20 (1) ◽  
pp. 142-148 ◽  
Author(s):  
Vassilios P. Kozobolis ◽  
Mikes Glynatsis ◽  
Georgios Labiris ◽  
Andreas Katsanos ◽  
Michael Fanariotis ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Exfoliative Glaucoma

scholarly journals SELENIUM AND SELENOPROTEIN P1 LEVELS ARE RELATED TO PRIMARY OPEN-ANGLE GLAUCOMA / NIVOI SELENA I SELENOPROTEINA P1 POVEZANI SU SA PRIMARNIM GLAUKOMOM OTVORENOG UGLA

2013 ◽  
Vol 33 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Mohammad Najafi ◽  
Morteza Nouruzi Yeganeh ◽  
Arezoo Miraftabi ◽  
Reza Zarei ◽  
Isa Noormohammadi
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Reduced Glutathione ◽  
Open Angle Glaucoma ◽  
Serum Levels ◽  
Visual Field Defects ◽  
Unknown Etiology ◽  
Serum Selenium ◽  
Open Angle ◽  
Significant Difference

Summary Background Glaucoma is a highly prevalent eye disease related to optic nerve lesions and visual field defects. Primary Open-Angle Glaucoma (POAG) is a type of glaucoma that occurs frequently with unknown etiology. In this study, we investigated the serum levels of selenium, selenoprotein P1, glutathione, hemolysate glutathione peroxidase1 (GPx1) activity and aqueous humour selenium in POAG patients. Methods Ninety sex- and age-matched subjects (POAG patients; n=45 and, controls; n=45) with the controlled confounders (smoking, hypertension and alcohol beverages) were recruited on clinical histories and exams. The serum and aqueous humour selenium levels were measured using GFAAS technique. The serum selenoprotein P1 level was assayed with the ELISA method. The hemolysate GPx1 activity and serum reduced glutathione level were also measured using known colorimetric techniques. Results The serum selenium (P=0.01) and selenoprotein P1 (P<0.001) levels were significantly high in POAG patients. Furthermore, the aqueous humour selenium level was significantly high among patients as compared to controls (64.68±13.07 vs. 58.36±13.76 ng/mL, P=0.02). The results did not show a significant difference (P=0.36) in the hemolysate GPx1 activity between the groups. The cutoff points for intraocular pressure (IOP) and serum selenoprotein P1 parameters were estimated to be 39 mmHg (sensitivity 97.5%; 1-specificity 6.5%) and 188 mg/mL (sensitivity 93.5%; 1-specificity 14%), respectively.

Sign in / Sign up

Export Citation Format

Share Document