The influence of gene polymorphisms on postprandial triglyceride response after oral fat tolerance test meal in patients with diabetes mellitus

2019 ◽  
Vol 73 (12) ◽  
Author(s):  
Paraskevi Gavra ◽  
Vana Kolovou ◽  
Athanasia K. Papazafiropoulou ◽  
Andreas Melidonis ◽  
Stella Iraklianou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Test Meal ◽  
Gene Polymorphisms ◽  
Tolerance Test ◽  
Oral Fat Tolerance Test ◽  
Postprandial Triglyceride ◽  
Patients With Diabetes ◽  
Fat Tolerance Test

scholarly journals Postprandial leptin and adiponectin in response to sugar and fat in obese and normal weight individuals

Endocrine ◽  
2019 ◽  
Vol 66 (3) ◽  
pp. 517-525 ◽  
Author(s):  
M. A. Larsen ◽  
V. T. Isaksen ◽  
E. J. Paulssen ◽  
R. Goll ◽  
J. R. Florholmen
Keyword(s):  
Tolerance Test ◽  
Normal Weight ◽  
Substantial Part ◽  
Oral Glucose ◽  
Industrialized Countries ◽  
Oral Fat Tolerance Test ◽  
Postprandial Triglyceride ◽  
Fat Tolerance Test ◽  
Lifestyle Diseases

Abstract Purpose Adipokines produced by white adipose tissue are central in the development of lifestyle diseases. Individuals in industrialized countries spend a substantial part of life in the non-fasting, postprandial state, which is associated with increased oxidation and inflammation. The aim was to study postprandial adiponectin and leptin levels after an oral fat tolerance test (OFTT) and an oral glucose tolerance test (OGTT) in obese (OB) and healthy, normal weight individuals (NW). Methods Fifty adults with obesity (BMI ≥ 30) and 17 healthy, NW were included. Postprandial triglyceride (TG), adiponectin, and leptin levels were measured every second hour during an 8 h OFTT, and every half hour during a 2 h OGTT. Results Compared with the basal level, postprandial levels of adiponectin following OFTT showed a slight initial peak, followed by a significant decrease at 8 h, in the NW. In the OB these changes were abolished. Postprandial levels of leptin decreased significantly from basal levels in the OFTT, in the NW, whereas in the OB, leptin was unchanged except for a slight increase from 2 to 8 h. During the OGTT both adiponectin and leptin levels remained unchanged in the NW, but decreased significantly in the OB. In addition, the OB had delayed TG clearance at 6 h. Conclusions A fatty meal gives postprandial changes in the secretion of adiponectin and leptin in NW, but not in OB. Our observations indicate that a potential postprandial regulatory role of adiponectin and leptin is impaired in OB, and of importance in a more comprehensive understanding of the delayed postprandial TG clearance in obese individuals.

scholarly journals Nonexercise Activity Thermogenesis-Induced Energy Shortage Improves Postprandial Lipemia and Fat Oxidation

Life ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 166
Author(s):  
Chih-Hui Chiu ◽  
Che-Hsiu Chen ◽  
Min-Huan Wu ◽  
Yin-Fu Ding
Keyword(s):  
Postprandial Lipemia ◽  
Area Under The Curve ◽  
Random Order ◽  
Fat Oxidation ◽  
Tolerance Test ◽  
High Fat ◽  
Fasted State ◽  
Oral Fat Tolerance Test ◽  
Postprandial Triglyceride ◽  
Fat Tolerance Test

(1) Background: This study investigated the effect of nonexercise activity thermogenesis on postprandial triglyceride (TG) concentrations; (2) Methods: Ten healthy males completed a sedentary trial (ST) and a physical activity trial (PA) in a random order separated by at least 7 days. After each intervention on day 1, the participants consumed a high-fat test meal on the next day. The blood samples and gas sample were observed in the fasted state and for 4 h after consuming the oral fat tolerance test; (3) Results: The postprandial TG concentrations of total (AUC) (p = 0.008) and incremental area under the curve (IAUC) (p = 0.023) in the plasma of participants in the PA trial were significantly lower than those in the plasma of participants in the ST trial. The postprandial fat oxidation rate AUC of the PA trial was significantly higher than that of the ST trial (p = 0.009); (4) Conclusions: The results of this study indicated that nonexercise energy expenditure decrease the postprandial TG concentration and increase the fat oxidation the next day.

scholarly journals Intrauterine growth-restricted Yucatan miniature pigs experience early catch-up growth, leading to greater adiposity and impaired lipid metabolism as young adults

2017 ◽  
Vol 42 (12) ◽  
pp. 1322-1329 ◽  
Author(s):  
Semone B. Myrie ◽  
Leslie L. McKnight ◽  
J. Christopher King ◽  
John J. McGuire ◽  
Bruce N. Van Vliet ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Tolerance Test ◽  
Abdominal Circumference ◽  
Intrauterine Growth ◽  
Miniature Pigs ◽  
Postprandial Triglyceride ◽  
Fat Tolerance Test ◽  
Catch Up ◽  
Ad Libitum ◽  
The Impact

Early nutrition has critical influences on cardiovascular disease risk in adulthood. The study objectives were to evaluate the impact of low birth weight on fasting and postprandial lipid metabolism and endothelium function in Yucatan miniature pigs. Intrauterine growth-restricted (IUGR) piglets (n = 6; 3 days old, 0.73 ± 0.04 kg) were paired with normal-weight (NW) same-sex littermates (n = 6; 1.11 ± 0.05 kg) and fed milk replacer ad libitum for 4 weeks. Thereafter, all pigs were fed a standard diet ad libitum for 5 h/day with growth, intakes, and blood samples collected for 8 months. At 9 months old, pigs were surgically fitted with venous catheters and an oral fat tolerance test was performed. At 10 months old, pigs were killed and endothelium-dependent and -independent vasodilations of isolated coronary arteries were measured using wire-myographs. IUGR pigs demonstrated catch-up growth (P < 0.05) in body weight and abdominal circumference prior to sexual maturity (<7 months old) and had more (P < 0.05) subcutaneous fat at 10 months old compared with NW pigs. IUGR pigs had consistently higher fasting plasma triglyceride concentrations from 5 to 10 months old and higher liver triglyceride and total cholesterol concentrations at 10 months old (P < 0.05). The fat tolerance test revealed delayed postprandial triglyceride clearance in IUGR pigs, but no differences in plaque formation or vascular reactivity. To conclude, IUGR and early postnatal catch-up growth are associated with increased overall body fat deposition and altered triglyceride metabolism in adult Yucatan miniature swine.

Incorporation of marine oils in an oral fat tolerance test reduces the postprandial plasma triglyceride response

1988 ◽  
Vol 74 (3) ◽  
pp. 257
Author(s):  
W. Richmond ◽  
M. Feher ◽  
A. Smith ◽  
McTaggart ◽  
R.S. Elkeles
Keyword(s):  
Tolerance Test ◽  
Plasma Triglyceride ◽  
Marine Oils ◽  
Oral Fat Tolerance Test ◽  
Fat Tolerance Test

C34 Endothelial dysfunction after an oral fat tolerance test (OFTT)

1999 ◽  
Vol 145 ◽  
pp. S9
Author(s):  
S Marchesi ◽  
G Lupattelli ◽  
B Palumbo ◽  
M Pirro ◽  
D Siepi ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Tolerance Test ◽  
Oral Fat Tolerance Test ◽  
Fat Tolerance Test

scholarly journals Oral Fat Tolerance Test for Sitosterolemia and Familial Hypercholesterolemia: A Study Protocol

2018 ◽  
Vol 25 (8) ◽  
pp. 741-746 ◽  
Author(s):  
Akihiro Nomura ◽  
Hayato Tada ◽  
Atsushi Nohara ◽  
Masa-aki Kawashiri ◽  
Masakazu Yamagishi
Keyword(s):  
Familial Hypercholesterolemia ◽  
Study Protocol ◽  
Tolerance Test ◽  
Oral Fat Tolerance Test ◽  
Fat Tolerance Test

scholarly journals A Randomized Crossover Trial on the Effects of Whole Apple Consumption on Postprandial Response to an Oral Fat Tolerance Test in Overweight and Obese Individuals (P08-109-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Xinjie (Lois) Lin ◽  
Danyelle Liddle ◽  
Hannah Neizer ◽  
Lindsay Robinson ◽  
Amanda Wright
Keyword(s):  
Gastric Emptying ◽  
Peak Concentration ◽  
Tolerance Test ◽  
Food Matrix ◽  
High Fat ◽  
Cvd Risk ◽  
Gastric Emptying Rate ◽  
Oral Fat Tolerance Test ◽  
Postprandial Response ◽  
Fat Tolerance Test

Abstract Objectives Postprandial lipemia (PPL) is a possible target for dietary strategies seeking to reduce cardiovascular disease (CVD) risk, including in overweight and obese individuals. Apples contain pectin and polyphenols that have shown potential to modulate PPL in in vitro and animal studies. However, whole apples, as a complex food matrix, have not been investigated in terms of their impact on PPL in humans. Therefore, this study used an oral fat tolerance test (OFTT) with the aim of exploring the influence of co-ingesting whole apples with a high fat dairy beverage on PPL and possible mediators, including chylomicron metabolism, glycemia, insulinemia and gastric emptying in generally healthy, but overweight and obese adults. Methods Six overweight and 20 obese participants (17 women and 9 men, mean ± SEM age of 45.5 ± 3.1 years, BMI of 34.1 ± 0.2 kg/m2, and fasting triacylglycerol (TAG) of 1.38 ± 0.08 mmol/L) completed this randomized, crossover acute meal study. After fasted participants consumed the OFTT (1 g fat/kg body weight, containing 1500 mg acetaminophen per meal for estimating gastric emptying rate) with and without 3 apples (∼200 g), plasma TAG, ApoB48, glucose, insulin, acetaminophen, and chylomicron-rich fraction (CMRF) particle size and fatty acid composition were analyzed over 6 hours. Differences in postprandial response (i.e., mean concentration, peak concentration (Cmax), time to peak (Tmax) and incremental area under the curve) between treatments were assessed by analysis of covariance. Results Consuming whole apples with the OFTT did not modify postprandial TAG, CMRF properties, glucose or gastric emptying rate (P > 0.05), but led to a higher Apo48 peak concentration (P < 0.01) and higher insulin concentrations between 20–180 min (P < 0.05). Conclusions Consumption of apples, as a complex food matrix containing pectin and polyphenols, did not alter overall PPL following a high fat meal, but did lead to initially higher postprandial insulin. These results have relevance for using apples as a dietary strategy to manage CVD risk associated with high fat consumption in overweight and obese individuals. Funding Sources Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA) and Ontario Apple Growers, Canada.

Gender-related differences in endothelial function after an oral fat tolerance test (OFTT) in healthy subjects

1999 ◽  
Vol 144 ◽  
pp. 51
Author(s):  
S. Marchesi ◽  
G. Lupattelli ◽  
M. Pirro ◽  
D. Siepi ◽  
B. Palumbo ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Healthy Subjects ◽  
Tolerance Test ◽  
Oral Fat Tolerance Test ◽  
Fat Tolerance Test
Sign in / Sign up

Export Citation Format

Share Document