scholarly journals Changes in liver gluconeogenesis during the development of Walker-256 tumour in rats

2013 ◽  
Vol 94 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Carolina Campos Lima Moreira ◽  
Priscila Cassolla ◽  
Ana Paula Segantini Dornellas ◽  
Hely de Morais ◽  
Camila Oliveira de Souza ◽  
...  
Keyword(s):  
Walker 256 Tumour ◽  
Walker 256

scholarly journals A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life

Metabolites ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 404
Author(s):  
Gabriela de Matuoka e Chiocchetti ◽  
Leisa Lopes-Aguiar ◽  
Natália Angelo da Silva Miyaguti ◽  
Lais Rosa Viana ◽  
Carla de Moraes Salgado ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Time Course ◽  
Cancer Cachexia ◽  
Tumour Bearing ◽  
Walker 256 Tumour ◽  
Walker 256 ◽  
Muscle Changes ◽  
The Right ◽  
Biomarker Research ◽  
Host Metabolism

Cancer cachexia is a severe wasting condition that needs further study to find ways to minimise the effects of damage and poor prognosis. Skeletal muscle is the most impacted tissue in cancer cachexia; thus, elucidation of its metabolic alterations could provide a direct clue for biomarker research and be applied to detect this syndrome earlier. In addition, concerning the significant changes in the host metabolism across life, this study aimed to compare the metabolic muscle changes in cachectic tumour-bearing hosts at different ages. We performed 1H-NMR metabolomics in the gastrocnemius muscle in weanling and young adult Walker-256 tumour-bearing rats at different stages of tumour evolution (initial, intermediate, and advanced). Among the 49 metabolites identified, 24 were significantly affected throughout tumour evolution and 21 were significantly affected regarding animal age. The altered metabolites were mainly related to increased amino acid levels and changed energetic metabolism in the skeletal muscle, suggesting an expressive catabolic process and diverted energy production, especially in advanced tumour stages in both groups. Moreover, these changes were more severe in weanling hosts throughout tumour evolution, suggesting the distinct impact of cancer cachexia regarding the host’s age, highlighting the need to adopting the right animal age when studying cancer cachexia.

scholarly journals The Fate of Circulating Walker 256 Tumour Cells injected Intravenously in Rats

1963 ◽  
Vol 17 (3) ◽  
pp. 546-557 ◽  
Author(s):  
J D Griffiths ◽  
A J Salsbury
Keyword(s):  
Tumour Cells ◽  
Walker 256 Tumour ◽  
Walker 256

scholarly journals Moderate exercise training since adolescence reduces Walker 256 tumour growth in adult rats

2019 ◽  
Vol 597 (15) ◽  
pp. 3905-3925 ◽  
Author(s):  
Veridiana Mota Moreira ◽  
Douglas Almeida ◽  
Claudinéia Conationi da Silva Franco ◽  
Rodrigo Mello Gomes ◽  
Kesia Palma‐Rigo ◽  
...  
Keyword(s):  
Exercise Training ◽  
Tumour Growth ◽  
Moderate Exercise ◽  
Adult Rats ◽  
Walker 256 Tumour ◽  
Walker 256 ◽  
Moderate Exercise Training

Walker 256 tumour growth causes marked changes of glutamine metabolism in rat small intestine

2002 ◽  
Vol 20 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Manuela M. Ramos Lima ◽  
Maria Alice R. de Mello ◽  
Rui Curi
Keyword(s):  
Small Intestine ◽  
Tumour Growth ◽  
Glutamine Metabolism ◽  
Rat Small Intestine ◽  
Walker 256 Tumour ◽  
Walker 256

scholarly journals Walker-256 Tumour-Induced Cachexia Altered Liver Metabolomic Profile and Function in Weanling and Adult Rats

Metabolites ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 831
Author(s):  
Natália Angelo da Silva Miyaguti ◽  
Gabriela de Matuoka e Chiocchetti ◽  
Carla de Moraes Salgado ◽  
Leisa Lopes-Aguiar ◽  
Lais Rosa Viana ◽  
...  
Keyword(s):  
Young Adult ◽  
Cancer Cachexia ◽  
Liver Lipid ◽  
Preclinical Model ◽  
Energy Status ◽  
Advanced Cancer Patients ◽  
Adult Rats ◽  
Tumour Bearing ◽  
Walker 256 Tumour ◽  
Walker 256

Cancer cachexia occurs in up to 85% of advanced cancer patients, affecting different tissues and organs, mainly the liver, which plays a central role in body metabolism control. However, liver responses to cancer cachexia progression are still poorly understood. Considering the possible different challenges provided by the rodent’s phase of life and the cachexia progression, we evaluated the liver metabolic alterations affected by Walker-256 tumour growth in weanling and young-adult rats. For this, we applied a metabolomics approach associated with protein and gene expression analyses. Higher amino acid levels and impaired glucose metabolism were important features in tumour-bearing animals’ liver tissue. The weanling hosts had more pronounced cachexia, with higher carcass spoliation, liver lipid metabolism and impaired CII and CIV mitochondrial complexes. The liver alterations in young adult tumour-bearing rats were related to energy status and nucleotide metabolites, such as uridine, NAD+, xanthosine, hypoxanthine and inosine. In conclusion, the Walker-256 tumour-induced cachexia impaired liver metabolism, being more severe in the weanling hosts. Further studies are needed to correlate these changes in the preclinical model, which can be correlated to the clinical features of cancer cachexia, allowing for a translational potential involving the liver function and its responses to potential treatments.

Metabolic fluxes in the liver of rats bearing the Walker-256 tumour: influence of the circulating levels of substrates and fatty acids

2007 ◽  
Vol 26 (1) ◽  
pp. 51-63 ◽  
Author(s):  
Renata P. da Veiga ◽  
Mário H. R. Alves da Silva ◽  
Graziele R. Teodoro ◽  
Nair Seiko Yamamoto ◽  
Jorgete Constantin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Metabolic Fluxes ◽  
Walker 256 Tumour ◽  
Walker 256 ◽  
Circulating Levels
Sign in / Sign up

Export Citation Format

Share Document