scholarly journals Moderate exercise training since adolescence reduces Walker 256 tumour growth in adult rats

2019 ◽  
Vol 597 (15) ◽  
pp. 3905-3925 ◽  
Author(s):  
Veridiana Mota Moreira ◽  
Douglas Almeida ◽  
Claudinéia Conationi da Silva Franco ◽  
Rodrigo Mello Gomes ◽  
Kesia Palma‐Rigo ◽  
...  
Keyword(s):  
Exercise Training ◽  
Tumour Growth ◽  
Moderate Exercise ◽  
Adult Rats ◽  
Walker 256 Tumour ◽  
Walker 256 ◽  
Moderate Exercise Training

scholarly journals Chronic Glibenclamide Treatment Attenuates Walker-256 Tumour Growth in Prediabetic Obese Rats

2017 ◽  
Vol 42 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Claudinéia Conationi da Silva Franco ◽  
Carina Previate ◽  
Kátia Gama de Barros Machado ◽  
Silvano Piovan ◽  
Rosiane Aparecida Miranda ◽  
...  
Keyword(s):  
Tumour Growth ◽  
Tumour Cells ◽  
Diabetic Patients ◽  
Adult Rats ◽  
Walker 256 Tumour ◽  
Tumour Growth Inhibition ◽  
Walker 256 ◽  
Growth Methods ◽  
Tumour Weight

Background/Aims: The sulphonylurea glibenclamide (Gli) is widely used in the treatment of type 2 diabetes. In addition to its antidiabetic effects, low incidences of certain types of cancer have been observed in Gli-treated diabetic patients. However, the mechanisms underlying this observation remain unclear. The aim of the present work was to evaluate whether obese adult rats that were chronically treated with an antidiabetic drug, glibenclamide, exhibit resistance to rodent breast carcinoma growth. Methods: Neonatal rats were treated with monosodium L-glutamate (MSG) to induce prediabetes. Control and MSG groups were treated with Gli (2 mg/kg body weight/day) from weaning to 100 days old. After Gli treatment, the control and MSG rats were grafted with Walker-256 tumour cells. After 14 days, grafted rats were euthanized, and tumour weight as well as glucose homeostasis were evaluated. Results: Treatment with Gli normalized tissue insulin sensitivity and glucose tolerance, suppressed fasting hyperinsulinaemia, reduced fat tissue accretion in MSG rats, and attenuated tumour growth by 27% in control and MSG rats. Conclusions: Gli treatment also resulted in a large reduction in the number of PCNA-positive tumour cells. Although treatment did improve the metabolism of pre-diabetic MSG-rats, tumour growth inhibition may be a more direct effect of glibenclamide.

Moderate exercise training slows mammary tumour growth in adolescent rats

2003 ◽  
Vol 12 (4) ◽  
pp. 281-287 ◽  
Author(s):  
K C Westerlind ◽  
H L McCarty ◽  
P C Schultheiss ◽  
R Story ◽  
A H Reed ◽  
...  
Keyword(s):  
Exercise Training ◽  
Tumour Growth ◽  
Mammary Tumour ◽  
Moderate Exercise ◽  
Adolescent Rats ◽  
Moderate Exercise Training

Reversal of experimental hypoxia-induced pulmonary hypertension by moderate exercise training in mice

Pneumologie ◽  
2011 ◽  
Vol 65 (S 01) ◽  
Author(s):  
D Peters ◽  
C Klöpping ◽  
K Krüger ◽  
C Pilat ◽  
S Katta ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Exercise Training ◽  
Moderate Exercise ◽  
Moderate Exercise Training

scholarly journals Moderate exercise training modulates cytokine profile and sleep in elderly people

Cytokine ◽  
2012 ◽  
Vol 60 (3) ◽  
pp. 731-735 ◽  
Author(s):  
R.V.T. Santos ◽  
V.A.R. Viana ◽  
R.A. Boscolo ◽  
V.G. Marques ◽  
M.G. Santana ◽  
...  
Keyword(s):  
Exercise Training ◽  
Elderly People ◽  
Cytokine Profile ◽  
Moderate Exercise ◽  
Moderate Exercise Training

scholarly journals Moderate exercise training promotes adaptations in coronary blood flow and adenosine production in normotensive rats

Clinics ◽  
2011 ◽  
Vol 66 (12) ◽  
pp. 2105-2111 ◽  
Author(s):  
Fernanda R. Roque ◽  
Ursula Paula Renó Soci ◽  
Katia De Angelis ◽  
Marcele A. Coelho ◽  
Cristina R. Furstenau ◽  
...  
Keyword(s):  
Blood Flow ◽  
Exercise Training ◽  
Coronary Blood Flow ◽  
Moderate Exercise ◽  
Moderate Exercise Training

scholarly journals Moderate exercise training reduces kidney oxidative stress and mortality of hypertensive diabetic rats

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Tatiana Sousa Cunha ◽  
Roberta Hack Mendes ◽  
Mariane Bertagnolli ◽  
Vinícius Viegas ◽  
Cristiano Teixeira Mostarda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Diabetic Rats ◽  
Moderate Exercise ◽  
Moderate Exercise Training

scholarly journals Moderate exercise prevents impaired Ca2+ handling in heart of CO-exposed rat: implication for sensitivity to ischemia-reperfusion

2010 ◽  
Vol 299 (6) ◽  
pp. H2076-H2081 ◽  
Author(s):  
C. Farah ◽  
G. Meyer ◽  
L. André ◽  
J. Boissière ◽  
S. Gayrard ◽  
...  
Keyword(s):  
Exercise Training ◽  
Antioxidant Status ◽  
Ischemia Reperfusion ◽  
Control Group ◽  
Moderate Exercise ◽  
Plasmic Reticulum ◽  
Rat Hearts ◽  
Perfused Rat Hearts ◽  
Exercise Induced ◽  
Moderate Exercise Training

Sustained urban carbon monoxide (CO) exposure exacerbates heart vulnerability to ischemia-reperfusion via deleterious effects on the antioxidant status and Ca2+ homeostasis of cardiomyocytes. The aim of this work was to evaluate whether moderate exercise training prevents these effects. Wistar rats were randomly assigned to a control group and to CO groups, living during 4 wk in simulated urban CO pollution (30–100 parts/million, 12 h/day) with (CO-Ex) or sedentary without exercise (CO-Sed). The exercise procedure began 4 wk before CO exposure and was maintained twice a week in standard filtered air during CO exposure. On one set of rats, myocardial ischemia (30 min) and reperfusion (120 min) were performed on isolated perfused rat hearts. On another set of rats, myocardial antioxidant status and Ca2+ handling were evaluated following environmental exposure. As a result, exercise training prevented CO-induced myocardial phenotypical changes. Indeed, exercise induced myocardial antioxidant status recovery in CO-exposed rats, which is accompanied by a normalization of sarco(endo)plasmic reticulum Ca2+-ATPase 2a expression and then of Ca2+ handling. Importantly, in CO-exposed rats, the normalization of cardiomyocyte phenotype with moderate exercise was associated with a restored sensitivity of the myocardium to ischemia-reperfusion. Indeed, CO-Ex rats presented a lower infarct size and a significant decrease of reperfusion arrhythmias compared with their sedentary counterparts. To conclude, moderate exercise, by preventing CO-induced Ca2+ handling and myocardial antioxidant status alterations, reduces heart vulnerability to ischemia-reperfusion.

Moderate exercise training decreases inflammation in transgenic sickle cell mice

2018 ◽  
Vol 69 ◽  
pp. 45-52 ◽  
Author(s):  
Emmanuelle Charrin ◽  
John J. Dubé ◽  
Philippe Connes ◽  
Vincent Pialoux ◽  
Samit Ghosh ◽  
...  
Keyword(s):  
Exercise Training ◽  
Sickle Cell ◽  
Moderate Exercise ◽  
Moderate Exercise Training
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