Metabolic fluxes in the liver of rats bearing the Walker-256 tumour: influence of the circulating levels of substrates and fatty acids

2007 ◽  
Vol 26 (1) ◽  
pp. 51-63 ◽  
Author(s):  
Renata P. da Veiga ◽  
Mário H. R. Alves da Silva ◽  
Graziele R. Teodoro ◽  
Nair Seiko Yamamoto ◽  
Jorgete Constantin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Metabolic Fluxes ◽  
Walker 256 Tumour ◽  
Walker 256 ◽  
Circulating Levels

scholarly journals A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life

Metabolites ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 404
Author(s):  
Gabriela de Matuoka e Chiocchetti ◽  
Leisa Lopes-Aguiar ◽  
Natália Angelo da Silva Miyaguti ◽  
Lais Rosa Viana ◽  
Carla de Moraes Salgado ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Time Course ◽  
Cancer Cachexia ◽  
Tumour Bearing ◽  
Walker 256 Tumour ◽  
Walker 256 ◽  
Muscle Changes ◽  
The Right ◽  
Biomarker Research ◽  
Host Metabolism

Cancer cachexia is a severe wasting condition that needs further study to find ways to minimise the effects of damage and poor prognosis. Skeletal muscle is the most impacted tissue in cancer cachexia; thus, elucidation of its metabolic alterations could provide a direct clue for biomarker research and be applied to detect this syndrome earlier. In addition, concerning the significant changes in the host metabolism across life, this study aimed to compare the metabolic muscle changes in cachectic tumour-bearing hosts at different ages. We performed 1H-NMR metabolomics in the gastrocnemius muscle in weanling and young adult Walker-256 tumour-bearing rats at different stages of tumour evolution (initial, intermediate, and advanced). Among the 49 metabolites identified, 24 were significantly affected throughout tumour evolution and 21 were significantly affected regarding animal age. The altered metabolites were mainly related to increased amino acid levels and changed energetic metabolism in the skeletal muscle, suggesting an expressive catabolic process and diverted energy production, especially in advanced tumour stages in both groups. Moreover, these changes were more severe in weanling hosts throughout tumour evolution, suggesting the distinct impact of cancer cachexia regarding the host’s age, highlighting the need to adopting the right animal age when studying cancer cachexia.

scholarly journals The Fate of Circulating Walker 256 Tumour Cells injected Intravenously in Rats

1963 ◽  
Vol 17 (3) ◽  
pp. 546-557 ◽  
Author(s):  
J D Griffiths ◽  
A J Salsbury
Keyword(s):  
Tumour Cells ◽  
Walker 256 Tumour ◽  
Walker 256

scholarly journals Moderate exercise training since adolescence reduces Walker 256 tumour growth in adult rats

2019 ◽  
Vol 597 (15) ◽  
pp. 3905-3925 ◽  
Author(s):  
Veridiana Mota Moreira ◽  
Douglas Almeida ◽  
Claudinéia Conationi da Silva Franco ◽  
Rodrigo Mello Gomes ◽  
Kesia Palma‐Rigo ◽  
...  
Keyword(s):  
Exercise Training ◽  
Tumour Growth ◽  
Moderate Exercise ◽  
Adult Rats ◽  
Walker 256 Tumour ◽  
Walker 256 ◽  
Moderate Exercise Training

Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs

1991 ◽  
Vol 261 (4) ◽  
pp. E466-E472 ◽  
Author(s):  
C. C. Connolly ◽  
K. E. Steiner ◽  
R. W. Stevenson ◽  
D. W. Neal ◽  
P. E. Williams ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Synaptic Cleft ◽  
Saline Infusion ◽  
Conscious Dogs ◽  
Nonesterified Fatty Acids ◽  
Conscious Dog ◽  
Lipolytic Effect ◽  
Circulating Levels

The lipolytic and ketogenic effects of norepinephrine (NE) at levels present in the circulation or the synaptic cleft during stress were examined in the overnight-fasted conscious dog. Insulin and glucagon were maintained at basal levels while NE, at a rate of either 0.04 (n = 6) or 0.32 micrograms.kg-1.min-1 (n = 5), or saline (n = 6) was infused for 3 h. NE rose from 129 +/- 17 to 442 +/- 85 pg/ml (P less than 0.05) and 100 +/- 24 to 3,244 +/- 807 pg/ml (P less than 0.05) with the low and high infusion rates, respectively (unchanged with saline infusion). There were no significant changes in lipolysis or ketogenesis with saline infusion. Both low and high NE infusion produced sustained increases in glycerol (from 72 +/- 20 to 119 +/- 24 microM and 59 +/- 19 to 248 +/- 32 microM, respectively, both P less than 0.05), while nonesterified fatty acids (NEFA) rose from 609 +/- 85 to 952 +/- 100 and 767 +/- 140 to 2,054 +/- 199 microM (both P less than 0.05). Ketone levels and net hepatic production rose significantly only with the high NE infusion (from 88 +/- 10 to 266 +/- 46 microM and 1.30 +/- 0.26 to 7.62 +/- 1.48 mumol.kg-1.min-1, respectively, both P less than 0.05). The ratio of net hepatic ketone production to NEFA uptake rose 54% with high NE infusion. In conclusion, at circulating levels seen during stress, NE stimulates lipolysis but does not directly influence ketogenesis. At circulating levels projected to exist in the synaptic cleft during stress, NE has a potent lipolytic effect and stimulates ketogenesis.

scholarly journals Seasonal variation in the effect of dietary RNA on criteria of energy homoeostasis in the rat

1979 ◽  
Vol 41 (1) ◽  
pp. 183-196
Author(s):  
D. J. Heaf ◽  
D. G. Peers ◽  
J. I. Davies
Keyword(s):  
Fatty Acids ◽  
Nervous System ◽  
Seasonal Variation ◽  
Seasonal Influence ◽  
Dependent Change ◽  
Plasma Ffa ◽  
Sympathetic Nervous ◽  
And Control ◽  
Circulating Levels ◽  
Variable Susceptibility

1. RNA was administered to rats as part of a meal while standardizing food intake and minimizing the effects of psychological stress and diurnal metabolic rhythms. It was demonstrated that circulating levels of glucose and free fatty acids (FFA) in the animals, which were deprived of food for 48 h, were responsive to orally administered caffeine.2. Inclusion of RNA in the diet slightly but consistently reduced the normal postprandial hyperglycaemia. Its effect on plasma FFA was variable although statistically significant in some experiments. The differences between RNA- and control-fed animals were not attributable to differences in the rate of passage of digesta along the gastrointestinal tract.3. Evidence was obtained that the variability in the FFA response was related to a seasonally-dependent change in the state of the animals. The synchronizer (‘Zeitgeber’) responsible for this change was not identified and no satisfactory way of suppressing its effect was found.4. The present findings, taken in conjunction with those of previous workers, suggest that there is a seasonal influence on the sympathetic nervous system manifesting itself as a variable susceptibility to arousal or excitation.

scholarly journals Changes in liver gluconeogenesis during the development of Walker-256 tumour in rats

2013 ◽  
Vol 94 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Carolina Campos Lima Moreira ◽  
Priscila Cassolla ◽  
Ana Paula Segantini Dornellas ◽  
Hely de Morais ◽  
Camila Oliveira de Souza ◽  
...  
Keyword(s):  
Walker 256 Tumour ◽  
Walker 256
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