In vivo evaluation of some biophysical parameters of the facial skin of Indian subjects living in Mumbai. Part II: Variability with age and gender

2018 ◽  
Vol 40 (2) ◽  
pp. 141-147 ◽  
Author(s):  
L. Colomb ◽  
F. Flament ◽  
A. Wagle ◽  
Y. Idelcaid ◽  
D. Agrawal
Keyword(s):  
Facial Skin ◽  
Biophysical Parameters ◽  
In Vivo Evaluation ◽  
Age And Gender ◽  
And Gender

scholarly journals Impact of Body Site, Age, and Gender on the Collagen/Elastin Index by Noninvasive in vivo Vertical Two-Photon Microscopy

2017 ◽  
Vol 30 (5) ◽  
pp. 260-267 ◽  
Author(s):  
Carolin Czekalla ◽  
Karl-Heinz Schönborn ◽  
Nadine Döge ◽  
Sora Jung ◽  
Maxim E. Darvin ◽  
...  
Keyword(s):  
Body Site ◽  
Age And Gender ◽  
Two Photon Microscopy ◽  
Two Photon ◽  
And Gender

Failure of Demonstrated Clinical Efficacy of Antibiotic-Bonded Continuous Ambulatory Peritoneal Dialysis (CAPD) Catheters

1990 ◽  
Vol 10 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Stanley Z. Trooskin ◽  
Richard A. Harvey ◽  
T. w. J. Lennard ◽  
Ralph S. Greco
Keyword(s):  
Clinical Trial ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Infectious Complications ◽  
Clinical Report ◽  
Age And Gender ◽  
And Gender ◽  
To Receive

Previous in vitro, in vivo, and a preliminary clinical report have demonstrated efficacy of noncovalently bonding antibiotics to the surface of continuous ambulatory peritoneal dialysis (CAPO) catheters in decreasing infectious complications. A larger prospective randomized clinical trial was completed. Eighty-six patients with chronic renal failure were enrolled in the study and randomized to receive either a surfactant treated or untreated control catheter. All catheters were soaked in cefoxitin at the time of insertion. Groups were comparable in terms of pre-existing illnesses, age, and gender. No differences were shown in the incidence of cathetertract infections, peritonitis or mechanical complications. There was also no differences in microbiologic culture results. Therefore, it is concluded that this clinical trial did not demonstrate a reduction in catheter-related infectious complications by antibiotic bonding.

scholarly journals GH signaling in skeletal muscle and adipose tissue in healthy human subjects: impact of gender and age

2014 ◽  
Vol 171 (5) ◽  
pp. 623-631 ◽  
Author(s):  
Poul F Vestergaard ◽  
Mikkel H Vendelbo ◽  
Steen B Pedersen ◽  
Anders Juul ◽  
Steffen Ringgard ◽  
...  
Keyword(s):  
Human Subjects ◽  
Experimental Studies ◽  
Young Group ◽  
Healthy Human ◽  
Age And Gender ◽  
Healthy Human Subjects ◽  
Constitutive Overexpression ◽  
And Gender ◽  
The Impact

ObjectiveThe mechanisms underlying the impact of age and gender on the GH–IGF1 axis remain unclear. We tested the hypothesis that age and gender have impacts on GH signaling in human subjects in vivo.DesignA total of 20 healthy non-obese adults (‘young group’ <30 years (5F/5M) and ‘old group’ >60 years (5F/5M)) were studied after: i) an i.v. GH bolus (0.5 mg) and ii) saline.MethodsMuscle and fat biopsies were obtained after 30 and 120 min. Total and phosphorylated STAT5B proteins, gene expression of IGF1, SOCS1, SOCS2, SOCS3 and CISH, body composition, VO2max, and muscle strength were measured.ResultsIn the GH-unstimulated state, women displayed significantly elevated levels of CISH mRNA in muscle (P=0.002) and fat (P=0.05) and reduced levels of IGF1 mRNA in fat. Phosphorylated STAT5B (pSTAT5b) was maximally increased in all subjects 30 min after GH exposure and more pronounced in women when compared with men (P=0.01). IGF1, SOCS1, SOCS2, SOCS3, and CISH mRNA expression increased significantly in muscle after 120 min in all subjects with no impact of age and gender. GH-induced pSTAT5b correlated inversely with lean body mass (LBM; r=−0.56, P=0.01) and positively with the CISH mRNA response (r=0.533, P=0.05).Conclusioni) GH signaling in muscle and fat after a single GH bolus in healthy human subjects is age independent, ii) we hypothesize that constitutive overexpression of CISH may contribute to the relative GH resistance in women, and iii) experimental studies on the impact of sex steroid administration and physical training on GH signaling in human subjects in vivo are required.

In Vivo Whole-Body Resting Energy Expenditure and Insulin Action in Human Malignant Hyperthermia 

2000 ◽  
Vol 93 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Daniel Freymond ◽  
Olivier Dériaz ◽  
Philippe Frascarolo ◽  
Sebastian Reiz ◽  
Eric Jéquier ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Malignant Hyperthermia ◽  
Insulin Action ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Whole Body ◽  
Energy Turnover ◽  
Age And Gender ◽  
And Gender

Background Malignant hyperthermia (MH) is a pharmacogenetic disease triggered by volatile anesthetics or succinylcholine. The disorder is heterogenetic and caused by abnormal calcium regulation within skeletal muscle cells. No clear metabolic differences have been found in MH-susceptible (MHS) persons in vivo while not having MH episodes, but some reported signs suggest that insulin action and energy turnover might be altered in muscle of MHS persons. Methods In fasting and insulin-stimulated conditions, using the glucose clamp technique and indirect calorimetry, we assessed in vivo resting energy expenditure (REE) and nutrient utilization rates in 10 MHS, 5 MH-equivocal (MHE) and 10 MH-negative (MHN) persons from 14 families. With a model using the persons' fat-free mass, fat mass, age, and gender, we calculated their predicted REE and compared it with measured REE in 10 MHS and 10 MHN persons (measured - predicted = residual REE). Results In vivo measured REE and glucose disposal rates were similar in 10 MHS and 10 MHN persons. Only during insulin stimulation was residual REE greater in MHS persons (6.4%; P = 0. 013). Conclusions In vivo insulin action is unimpaired in MHS persons. Although the absolute values of whole-body REE are the same in MHS and MHN persons, the part of REE independent of the determinants fat-free mass, fat mass, age, and gender is moderately greater in MHS than in MHN persons during insulin exposure. This suggests that MH susceptibility might influence insulin-stimulated energy turnover in muscle.

scholarly journals In Vivo Assessment of Water Content, Trans-Epidermial Water Loss and Thickness in Human Facial Skin

2020 ◽  
Vol 10 (17) ◽  
pp. 6139
Author(s):  
Elena Chirikhina ◽  
Andrey Chirikhin ◽  
Perry Xiao ◽  
Sabina Dewsbury-Ennis ◽  
Francesco Bianconi
Keyword(s):  
Water Content ◽  
Water Loss ◽  
Cosmetic Surgery ◽  
Skin Thickness ◽  
Facial Skin ◽  
Biophysical Properties ◽  
In Vivo Evaluation ◽  
Practical Applications ◽  
Restorative Surgery

Mapping facial skin in terms of its biophysical properties plays a fundamental role in many practical applications, including, among others, forensics, medical and beauty treatments, and cosmetic and restorative surgery. In this paper we present an in vivo evaluation of the water content, trans-epidermial water loss and skin thickness in six areas of the human face: cheeks, chin, forehead, lips, neck and nose. The experiments were performed on a population of healthy subjects through innovative sensing devices which enable fast yet accurate evaluations of the above parameters. A statistical analysis was carried out to determine significant differences between the facial areas investigated and clusters of statistically-indistinguishable areas. We found that water content was higher in the cheeks and neck and lower in the lips, whereas trans-epidermal water loss had higher values for the lips and lower ones for the neck. In terms of thickness the dermis exhibited three clusters, which, from thickest to thinnest were: chin and nose, cheek and forehead and lips and neck. The epidermis showed the same three clusters too, but with a different ordering in term of thickness. Finally, the stratum corneum presented two clusters: the thickest, formed by lips and neck, and the thinnest, formed by all the remaining areas. The results of this investigation can provide valuable guidelines for the evaluation of skin moisturisers and other cosmetic products, and can help guide choices in re-constructive/cosmetic surgery.

scholarly journals An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo

2021 ◽  
Vol 218 (6) ◽  
Author(s):  
Xulun Zhang ◽  
Can Martin Zhang ◽  
Dmitry Prokopenko ◽  
Yingxia Liang ◽  
Sherri Y. Zhen ◽  
...  
Keyword(s):  
Coding Region ◽  
Age And Gender ◽  
Single Nucleotide ◽  
Aβ Peptides ◽  
Transfected Cells ◽  
And Gender ◽  
App Gene ◽  
Aβ Production

Familial Alzheimer’s disease (FAD)–linked mutations in the APP gene occur either within the Aβ-coding region or immediately proximal and are located in exons 16 and 17, which encode Aβ peptides. We have identified an extremely rare, partially penetrant, single nucleotide variant (SNV), rs145081708, in APP that corresponds to a Ser198Pro substitution in exon 5. We now report that in stably transfected cells, expression of APP harboring the S198P mutation (APPS198P) leads to elevated production of Aβ peptides by an unconventional mechanism in which the folding and exit of APPS198P from the endoplasmic reticulum is accelerated. More importantly, coexpression of APP S198P and the FAD-linked PS1ΔE9 variant in the brains of male and female transgenic mice leads to elevated steady-state Aβ peptide levels and acceleration of Aβ deposition compared with age- and gender-matched mice expressing APP and PS1ΔE9. This is the first AD-linked mutation in APP present outside of exons 16 and 17 that enhances Aβ production and deposition.

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