scholarly journals Reflectance confocal microscopy may enhance the accuracy of histopathologic diagnosis: A case series

2019 ◽  
Vol 46 (11) ◽  
pp. 830-838 ◽  
Author(s):  
Neda Shahriari ◽  
Jane M. Grant‐Kels ◽  
Harold Rabinovitz ◽  
Margaret Oliviero ◽  
Alon Scope
Keyword(s):  
Confocal Microscopy ◽  
Case Series ◽  
Reflectance Confocal Microscopy ◽  
Histopathologic Diagnosis

scholarly journals Reflectance Confocal Microscopy of Pigmented Bowen’s Disease: A Case Series of Difficult to Diagnose Lesions

2020 ◽  
Vol 12 (2) ◽  
pp. 98-106
Author(s):  
Sara Mazzilli ◽  
Reyes Gamo-Villegas ◽  
Ana Pampin-Franco ◽  
Jose Luis Lopez Estebaran ◽  
Fernando Pinedo ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Case Series ◽  
The Body ◽  
Reflectance Confocal Microscopy ◽  
Bowen’S Disease ◽  
Seborrheic Keratosis ◽  
Bowen's Disease ◽  
Precise Diagnosis

Pigmented Bowen’s disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body. The best-characterized feature of the disease by histological examination is the presence of atypical keratinocytes, hyperpigmentation of the epidermis with trans-epidermal elimination of melanin and dermal melanophages. Precise diagnosis is often difficult, both clinically and dermoscopically, as Bowen’s disease is often mistaken with keratinocyte tumors such as solar lentigines, seborrheic keratosis, Bowenoid papulosis, pigmented basal cell carcinoma, pigmented actinic keratosis; or even melanocytic lesions such as melanocytic nevus, pigmented epithelioid melanocytoma, and melanoma. Precise diagnosis often requires biopsy and histopathological examination of the tissue. Reflectance confocal microscopy is a noninvasive technique to diagnose pigmented skin lesions. To date, not much data are available regarding its use in the diagnosis of pigmented Bowen’s disease. Herein, we report a well-represented case series of pigmented Bowen’s disease imaged using dermoscopy and reflectance confocal microscopy.

The combined role of clinical, reflectance confocal microscopy and dermoscopy applied to chronic discoid cutaneous lupus and subacutus lupus erythematosus: A case series and literature review

Lupus ◽  
2020 ◽  
Vol 30 (1) ◽  
pp. 125-133
Author(s):  
Sara Mazzilli ◽  
Laura Vollono ◽  
Laura Diluvio ◽  
Elisabetta Botti ◽  
Gaetana Costanza ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Case Series ◽  
Skin Lesions ◽  
Reflectance Confocal Microscopy ◽  
Discoid Lupus Erythematosus ◽  
Cutaneous Lupus

Main subtypes of cutaneous lupus erythematosus are represented by acute, subacute cutaneous, intermittent and chronic cutaneous lupus erythematosus. Discoid lupus erythematosus represents the most common phenotype of chronic cutaneous lupus erythematosus. The spectrum of clinical manifestations mirrors that of several and distinct histopathological features. Such variability among different CLE subtypes is also observed at dermoscopy. Dermoscopy is nowadays considered an additional valuable method for skin lesions assessment in general dermatology, following and completing the well-known clinical diagnostic steps, such as medical history and clinical examination. In vivo reflectance confocal microscopy (RCM) is a non-invasive imaging tool able to assess the epidermis and upper dermis producing high resolution (horizontal ∼1.25 μm, vertical ∼5 μm), en face tissue sections used for melanocytic and inflammatory evaluation. In this study, we reported dermoscopic and RCM features about 9 patients affected by subacute and chronic lupus erythematosus retrospectively analyzed.

Reflectance confocal microscopy in Darier disease: A case series with dermoscopic and histologic correlation

2019 ◽  
Vol 25 (3) ◽  
pp. 404-406
Author(s):  
André Oliveira ◽  
Virginia Coelho de Sousa ◽  
Rita Pimenta ◽  
Paulo Leal‐Filipe
Keyword(s):  
Confocal Microscopy ◽  
Case Series ◽  
Reflectance Confocal Microscopy ◽  
Darier Disease
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