In vivo reflectance confocal microscopy of erythema multiforme and Stevens-Johnson syndrome: a histopathological correlation based on a case series

2017 ◽  
Vol 15 (5) ◽  
pp. 573-576 ◽  
Author(s):  
Kinga T. Samhaber ◽  
Hans Peter Bertsch ◽  
Michael P. Schön ◽  
Holger A. Haenssle
Keyword(s):  
Confocal Microscopy ◽  
Erythema Multiforme ◽  
Case Series ◽  
Reflectance Confocal Microscopy ◽  
Stevens Johnson Syndrome ◽  
Histopathological Correlation ◽  
Johnson Syndrome

The combined role of clinical, reflectance confocal microscopy and dermoscopy applied to chronic discoid cutaneous lupus and subacutus lupus erythematosus: A case series and literature review

Lupus ◽  
2020 ◽  
Vol 30 (1) ◽  
pp. 125-133
Author(s):  
Sara Mazzilli ◽  
Laura Vollono ◽  
Laura Diluvio ◽  
Elisabetta Botti ◽  
Gaetana Costanza ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Case Series ◽  
Skin Lesions ◽  
Reflectance Confocal Microscopy ◽  
Discoid Lupus Erythematosus ◽  
Cutaneous Lupus

Main subtypes of cutaneous lupus erythematosus are represented by acute, subacute cutaneous, intermittent and chronic cutaneous lupus erythematosus. Discoid lupus erythematosus represents the most common phenotype of chronic cutaneous lupus erythematosus. The spectrum of clinical manifestations mirrors that of several and distinct histopathological features. Such variability among different CLE subtypes is also observed at dermoscopy. Dermoscopy is nowadays considered an additional valuable method for skin lesions assessment in general dermatology, following and completing the well-known clinical diagnostic steps, such as medical history and clinical examination. In vivo reflectance confocal microscopy (RCM) is a non-invasive imaging tool able to assess the epidermis and upper dermis producing high resolution (horizontal ∼1.25 μm, vertical ∼5 μm), en face tissue sections used for melanocytic and inflammatory evaluation. In this study, we reported dermoscopic and RCM features about 9 patients affected by subacute and chronic lupus erythematosus retrospectively analyzed.

Use of handheld reflectance confocal microscopy for in vivo diagnosis of solitary facial papules: a case series

2013 ◽  
Vol 28 (7) ◽  
pp. 933-942 ◽  
Author(s):  
N.A. Fraga-Braghiroli ◽  
A. Stephens ◽  
D. Grossman ◽  
H. Rabinovitz ◽  
R.P.R. Castro ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Case Series ◽  
Reflectance Confocal Microscopy ◽  
In Vivo Diagnosis

Usefulness of in vivo reflectance confocal microscopy in Morbihan syndrome

2021 ◽  
Author(s):  
Arianna Rizzo ◽  
Diletta Fiorani ◽  
Laura Lazzeri ◽  
Paolo Taddeucci ◽  
Pietro Rubegni ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy

scholarly journals T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab

2021 ◽  
Vol 9 (5) ◽  
pp. e002521
Author(s):  
Sean Hammond ◽  
Anna Olsson-Brown ◽  
Joshua Gardner ◽  
Paul Thomson ◽  
Serat-E Ali ◽  
...  
Keyword(s):  
Contrast Media ◽  
Adverse Reactions ◽  
Stevens Johnson Syndrome ◽  
Iodinated Contrast ◽  
Immune Mediated ◽  
Johnson Syndrome ◽  
Healthy Donors ◽  
Concomitant Medications

Many adverse reactions associated with immune checkpoint inhibitor (ICI) treatments are immunologically driven and may necessitate discontinuation of the ICI. Herein, we present a patient who had been administered the radio contrast media amidotrizoate multiple times without issue but who then developed a Stevens-Johnson syndrome reaction after coadministration of atezolizumab. Causality was confirmed by a positive re-challenge with amidotrizoate and laboratory investigations that implicated T cells. Importantly, the introduction of atezolizumab appears to have altered the immunologic response to amidotrizoate in terms of the tolerance–elicitation continuum. Proof of concept studies demonstrated enhancement of recall responses to a surrogate antigen panel following in-vitro (healthy donors) and in-vivo (ICI patients) administrations of ICIs. Our findings highlight the importance of considering all concomitant medications in patients on ICIs who develop immune-mediated adverse reactions. In the event of some immune-related adverse reactions, it may be critical to identify the culprit antigen-forming entity that the ICIs have altered the perception of rather than simply attribute causality to the ICI itself in order to optimize both patient safety and treatment of malignancies.

scholarly journals In vivo reflectance confocal microscopy for the diagnosis of scabies

2021 ◽  
Vol 14 (1) ◽  
pp. e240507
Author(s):  
Mihai Lupu ◽  
Vlad Mihai Voiculescu ◽  
Cristina Vajaitu ◽  
Olguta Anca Orzan
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy

Monitoring vulvar melanoma response to combined immunotherapy and radiotherapy with in vivo reflectance confocal microscopy

2021 ◽  
Author(s):  
Cristian Navarrete‐Dechent ◽  
Miguel Cordova ◽  
Saud Aleissa ◽  
Alexander Shoushtari ◽  
Travis J. Hollmann ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Vulvar Melanoma ◽  
Combined Immunotherapy

Evaluating residual melanocytic atypia in a post‐excision scar using in vivo reflectance confocal microscopy

2021 ◽  
Author(s):  
Samavia Khan ◽  
Nadiya Chuchvara ◽  
Jennifer Cucalon ◽  
Attiya Haroon ◽  
Babar Rao
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy

In vivo characterization of recurrent dermatofibrosarcoma protuberans by dermoscopy and reflectance confocal microscopy

2016 ◽  
Vol 75 (5) ◽  
pp. e185-e187 ◽  
Author(s):  
Marina Venturini ◽  
Arianna Zanca ◽  
Ausilia Maria Manganoni ◽  
Laura Pavoni ◽  
Giulio Gualdi ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Dermatofibrosarcoma Protuberans ◽  
Reflectance Confocal Microscopy ◽  
In Vivo Characterization
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