Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series

2015 ◽  
Vol 172 (3) ◽  
pp. 816-818 ◽  
Author(s):  
T. Maier ◽  
D. Cekovic ◽  
T. Ruzicka ◽  
E.C. Sattler ◽  
C. Berking
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Case Series ◽  
Treatment Monitoring ◽  
Reflectance Confocal Microscopy ◽  
Optical Coherence ◽  
Ingenol Mebutate ◽  
Actinic Keratoses

scholarly journals Successful Treatment of Genital Warts with Ingenol Mebutate Monitored with Optical Coherence Tomography and Reflectance Confocal Microscopy

2019 ◽  
Vol 31 (4) ◽  
pp. 434 ◽  
Author(s):  
Markus Reinholz ◽  
Benjamin M. Clanner-Engelshofen ◽  
Markus V. Heppt ◽  
Yoji Hirai ◽  
Thomas Ruzicka ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Successful Treatment ◽  
Genital Warts ◽  
Reflectance Confocal Microscopy ◽  
Optical Coherence ◽  
Ingenol Mebutate

scholarly journals A Case Series of Bowen’s Disease Treated with the Combination of Cryosurgery and Ingenol Mebutate and Followed Up with Optical Coherence Tomography

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Georgios Gaitanis ◽  
Theodora Tsironi ◽  
Panagiota Spyridonos ◽  
Ioannis D. Bassukas
Keyword(s):  
Optical Coherence Tomography ◽  
Case Series ◽  
Treatment Monitoring ◽  
Optical Coherence ◽  
Bowen’S Disease ◽  
Ingenol Mebutate ◽  
Bowen's Disease ◽  
Maximal Diameter

Bowen’s disease (BD) is a relatively rare in situ squamous cell carcinoma (SCC) with a limited potential of becoming invasive. Ingenol mebutate (IM) was relatively successful for the treatment of BD lesions in small case series. Optical coherence tomography (OCT) is a promising method for the diagnosis of cutaneous keratinocytic carcinomas, including BD. Herein we report the treatment of BD with the combination of cryosurgery and IM and the application of OCT imagining in treatment monitoring. Patients treated within a period of 12 months are retrospectively compiled. Treatment consisted of a mild cryosurgery session (liquid N2, open spray, and 2 freeze-thaw cycles of 15 sec each) of a field including the BD lesion and a 0.5cm rim and IM application for 4 consecutive days starting at the cryosurgery day. Four patients (3 females; average age: 76.5 years) with 4 lesions (20-70mm maximal diameter; average 36.2mm) were included. Healing was excellent and no relapse was observed at 12 months’ follow-up. Baseline OCT revealed a disarranged, thickened epidermis, while a normally layered epidermis overlying a hyperreflective dermis was present after treatment. Conclusively, the combination of cryosurgery followed by IM is a feasible, effective treatment for BD that should be evaluated in further studies.

Acne vulgaris severity graded by in vivo reflectance confocal microscopy and optical coherence tomography

2018 ◽  
Vol 51 (1) ◽  
pp. 104-113 ◽  
Author(s):  
Christine S. K. Fuchs ◽  
Amanda J. B. Andersen ◽  
Marco Ardigo ◽  
Peter A. Philipsen ◽  
Merete Haedersdal ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Acne Vulgaris ◽  
Reflectance Confocal Microscopy ◽  
Optical Coherence
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