Subtypes of hypoxia-responsive cells differentiate into neurons in spinal cord of zebrafish embryos after hypoxic stress

2016 ◽  
Vol 108 (12) ◽  
pp. 357-377 ◽  
Author(s):  
Chih-Wei Zeng ◽  
Yasuhiro Kamei ◽  
Chih-Tien Wang ◽  
Huai-Jen Tsai
Keyword(s):  
Spinal Cord ◽  
Zebrafish Embryos ◽  
Hypoxic Stress

Hypoxic stress visualized in the cervical spinal cord of ALS patients

2020 ◽  
pp. 1-5
Author(s):  
Toru Yamashita ◽  
Tetsuhiro Hatakeyama ◽  
Kota Sato ◽  
Yusuke Fukui ◽  
Nozomi Hishikawa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Hypoxic Stress ◽  
Als Patients

Gene expression profile of zebrafish exposed to hypoxia during development

2003 ◽  
Vol 13 (2) ◽  
pp. 97-106 ◽  
Author(s):  
Christopher Ton ◽  
Dimitri Stamatiou ◽  
Choong-Chin Liew
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Cdna Microarray ◽  
Expression Profile ◽  
Clinical Implications ◽  
Zebrafish Embryos ◽  
Hypoxic Stress ◽  
Microarray Technology ◽  
Adaptive Responses ◽  
Low Oxygen

Understanding how vertebrates respond to hypoxia can have important clinical implications. Fish have evolved the ability to survive long exposure to low oxygen levels. However, little is known about the specific changes in gene expression that result from hypoxia. In this study we used a zebrafish cDNA microarray to examine the expression of >4,500 genes in zebrafish embryos exposed to 24 h of hypoxia during development. We tested the hypotheses that hypoxia changes gene expression profile of the zebrafish embryos and that these changes can be reverted by reexposure to a normoxic (20.8% O2) environment. Our data were consistent with both of these hypotheses: indicating that zebrafish embryos undergo adaptive changes in gene expression in response to hypoxia. Our study provides a striking genetic portrait of the zebrafish embryos’ adaptive responses to hypoxic stress and demonstrates the utility of the microarray technology as a tool for analyzing complex developmental processes in the zebrafish.

Involvement of Oct4‐type transcription factor Pou5f3 in posterior spinal cord formation in zebrafish embryos

2021 ◽  
Author(s):  
Tatsuya Yuikawa ◽  
Masaaki Ikeda ◽  
Sachiko Tsuda ◽  
Shinji Saito ◽  
Kyo Yamasu
Keyword(s):  
Spinal Cord ◽  
Transcription Factor ◽  
Zebrafish Embryos

scholarly journals Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos

2008 ◽  
Vol 237 (8) ◽  
pp. 2081-2089 ◽  
Author(s):  
Ho Kim ◽  
Jimann Shin ◽  
Suhyun Kim ◽  
Justin Poling ◽  
Hae-Chul Park ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Radial Glia ◽  
Zebrafish Embryos

scholarly journals The HMG box transcription factors Sox1a and Sox1b specify a new class of glycinergic interneuron in the spinal cord of zebrafish embryos

Development ◽  
2019 ◽  
Vol 146 (4) ◽  
pp. dev172510 ◽  
Author(s):  
Vanessa Gerber ◽  
Lixin Yang ◽  
Masanari Takamiya ◽  
Vanessa Ribes ◽  
Victor Gourain ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Transcription Factors ◽  
Zebrafish Embryos ◽  
Hmg Box ◽  
New Class

scholarly journals Glutamate drives the touch response through a rostral loop in the spinal cord of zebrafish embryos

2009 ◽  
Vol 69 (12) ◽  
pp. 780-795 ◽  
Author(s):  
Thomas Pietri ◽  
Elise Manalo ◽  
Joel Ryan ◽  
Louis Saint-Amant ◽  
Philip Washbourne
Keyword(s):  
Spinal Cord ◽  
Zebrafish Embryos ◽  
Touch Response

scholarly journals Pathfinding by identified growth cones in the spinal cord of zebrafish embryos

1990 ◽  
Vol 10 (4) ◽  
pp. 1299-1308 ◽  
Author(s):  
JY Kuwada ◽  
RR Bernhardt ◽  
AB Chitnis
Keyword(s):  
Spinal Cord ◽  
Growth Cones ◽  
Zebrafish Embryos

Segmental pattern of development of the hindbrain and spinal cord of the zebrafish embryo

Development ◽  
1988 ◽  
Vol 103 (1) ◽  
pp. 49-58 ◽  
Author(s):  
E. Hanneman ◽  
B. Trevarrow ◽  
W.K. Metcalfe ◽  
C.B. Kimmel ◽  
M. Westerfield
Keyword(s):  
Spinal Cord ◽  
Monoclonal Antibody ◽  
Early Development ◽  
Zebrafish Embryo ◽  
Single Cells ◽  
Acetylcholinesterase Activity ◽  
Zebrafish Embryos ◽  
Small Clusters ◽  
Spinal Motoneurones

In the ventral hindbrain and spinal cord of zebrafish embryos, the first neurones that can be identified appear as single cells or small clusters of cells, distributed periodically at intervals equal to the length of a somite. In the hindbrain, a series of neuromeres of corresponding length is present, and the earliest neurones are located in the centres of each neuromere. Young neurones within both the hindbrain and spinal cord were identified in live embryos using Nomarski optics, and histochemically by labelling for acetylcholinesterase activity and expression of an antigen recognized by the monoclonal antibody zn-1. Among them are individually identified hindbrain reticulospinal neurones and spinal motoneurones. These observations suggest that early development in these regions of the CNS reflects a common segmental pattern. Subsequently, as more neurones differentiate, the initially similar patterning of the cells in these two regions diverges. A continuous longitudinal column of developing neurones appears in the spinal cord, whereas an alternating series of large and small clusters of neurones is present in the hindbrain.

scholarly journals Tcf3 function is required for the inhibition of oligodendroglial fate specification in the spinal cord of zebrafish embryos

2011 ◽  
Vol 32 (4) ◽  
pp. 383-388 ◽  
Author(s):  
Suhyun Kim ◽  
Ah-Young Chung ◽  
Dohyun Kim ◽  
Young-Seop Kim ◽  
Hyung-Seok Kim ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Zebrafish Embryos ◽  
Fate Specification

scholarly journals Growth cone guidance by floor plate cells in the spinal cord of zebrafish embryos

Neuron ◽  
1992 ◽  
Vol 8 (5) ◽  
pp. 869-882 ◽  
Author(s):  
Robert R. Bernhardt ◽  
Nguyen Nguyen ◽  
John Y. Kuwada
Keyword(s):  
Spinal Cord ◽  
Growth Cone ◽  
Floor Plate ◽  
Zebrafish Embryos ◽  
Growth Cone Guidance
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