scholarly journals Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models

Aging Cell ◽  
2019 ◽  
Vol 18 (3) ◽  
pp. e12919 ◽  
Author(s):  
Laura Trujillo‐Estrada ◽  
Cassidy Nguyen ◽  
Celia da Cunha ◽  
Lena Cai ◽  
Stefania Forner ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Models ◽  
Cognitive Deficits ◽  
Diabetes Mouse

scholarly journals Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189

Diabetes ◽  
2019 ◽  
Vol 68 (11) ◽  
pp. 2143-2154 ◽  
Author(s):  
Corinne G. Jolivalt ◽  
Alexandra Marquez ◽  
David Quach ◽  
Michelle C. Navarro Diaz ◽  
Carlos Anaya ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Mouse Models

DIABETIC ENCEPHALOPATHY IN TYPE 2 DIABETES

2017 ◽  
pp. 52-58
Author(s):  
Van Vy Hau Nguyen ◽  
Hai Thuy Nguyen ◽  
Dinh Toan Nguyen
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Deficits ◽  
Organ Damage ◽  
Diabetic Encephalopathy ◽  
Downstream Effects ◽  
Increased Risk ◽  
Underlying Mechanisms ◽  
The Brain

Type 2 diabetes is a common metabolic disease with a rising global prevalence. It is associated with slowly progressive end-organ damage in the eyes and kidneys, but also in the brain. The latter complication is often referred to as "diabetic encephalopathy" and is characterized by mild to moderate impairments in cognitive functioning. It is also associated with an increased risk of dementia. Diabetic encephalopathies are now accepted complications of diabetes. To date, its pathogenetic mechanisms are largely unclear. They appear to differ in type 1 and type 2 diabetes as to underlying mechanisms and the nature of resulting cognitive deficits. The increased incidence of Alzheimer’s disease in type 2 diabetes is associated with insulin resistance, hyperinsulinemia and hyperglycemia, and commonly accompanying attributes such as hypercholesterolemia, hypertension and obesity. However, cognitive impairement in type 1 diabetes have other differences with type 2 diabetes. The major underlying component here appears to be insulin deficiency with downstream effects on the expression of neurotrophic factors, neurotransmitters, oxidative and apoptotic stressors resulting in defects in neuronal integrity, connectivity and loss commonly occurring in the still developing brain.

scholarly journals Hair corticosterone measurement in mouse models of type 1 and type 2 diabetes mellitus

2017 ◽  
Vol 178 ◽  
pp. 166-171 ◽  
Author(s):  
Rebecca L. Erickson ◽  
Caroline A. Browne ◽  
Irwin Lucki
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Models

scholarly journals Monoclonal therapy against calcitonin gene-related peptide lowers hyperglycemia and adiposity in type 2 diabetes mouse models

2020 ◽  
Vol 8 ◽  
pp. 100060
Author(s):  
Jonathan Halloran ◽  
Alexandre Lalande ◽  
Mandy Zang ◽  
Harshita Chodavarapu ◽  
Céline E. Riera
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Models ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Diabetes Mouse
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