Specific down‐regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes

2007 ◽  
Vol 21 (12) ◽  
pp. 3355-3368 ◽  
Author(s):  
Mausumee Guha ◽  
Zhong‐Gao Xu ◽  
David Tung ◽  
Linda Lanting ◽  
Rama Natarajan
Keyword(s):  
Type 2 Diabetes ◽  
Growth Factor ◽  
Connective Tissue ◽  
Mouse Models ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Down Regulation

scholarly journals A Polymorphism Within the Connective Tissue Growth Factor (CTGF) Gene has No Effect on Non-Invasive Markers of Beta-Cell Area and Risk of Type 2 Diabetes

2011 ◽  
Vol 31 (4) ◽  
pp. 241-246 ◽  
Author(s):  
Olga Pivovarova ◽  
Eva Fisher ◽  
Katarzyna Dudziak ◽  
Iryna Ilkavets ◽  
Steven Dooley ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Factor ◽  
Connective Tissue ◽  
Beta Cell ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Cell Area ◽  
Non Invasive ◽  
Beta Cell Area

Chromosomal locus 6q23 is strongly linked to type 2 diabetes (T2DM) and related features including insulin secretion in various ethnic populations. Connective tissue growth factor (CTGF) gene is an interesting T2DM candidate gene in this chromosome region. CTGF is a key mediator of progressive pancreatic fibrosis up-regulated in type 2 diabetes. In contrast,CTGFinactivation in mice compromises islet cell proliferation during embryogenesis. The aim of our study was to investigate an impact ofCTGFgenetic variation on pancreatic beta-cell function and T2DM pathogenesis. We studied the effect of a commonCTGFpolymorphism rs9493150 on the risk of the T2DM development in three independent German cohorts. Specifically, the association betweenCTGFpolymorphism and non-invasive markers of beta-cell area derived from oral glucose tolerance test was studied in subjects without diabetes. Neither in the Metabolic Syndrome Berlin Potsdam (MESYBEPO) study (n= 1026) (OR = 0.637, CI (0.387–1.050);p= 0.077) nor in the European Prospective Investigation into Cancer and Nutrition-Potsdam (EPIC-Potsdam) (n= 3049) cohort (RR = 0.77 CI (0.49–1.20),p= 0.249 for the recessive homozygote in general model), a significant association with increased diabetes risk was observed. The risk allele of rs9493150 had also no effect on markers of beta-cell area in the combined analysis of the MESYBEPO and Tübingen Family Study (n= 1826). In conclusion, the polymorphism rs9493150 in the 5’-untranslated region of theCTGFgene has no association with T2DM risk and surrogate markers of beta-cell area.

Levels of Connective Tissue Growth Factor (CTGF) Predict Development of Kidney Dysfunction in Type 2 Diabetes-The VADT Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 528-P ◽  
Author(s):  
KELLY J. HUNT ◽  
MIRAN A. JAFFA ◽  
SARA M. GARRETT ◽  
DEIRDRE K. LUTTRELL ◽  
KENNETH E. LIPSON ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Kidney Dysfunction

scholarly journals Connective Tissue Growth Factor Is Increased in Plasma of Type 1 Diabetic Patients With Nephropathy

Diabetes Care ◽  
2004 ◽  
Vol 27 (5) ◽  
pp. 1164-1170 ◽  
Author(s):  
P. Roestenberg ◽  
F. A. van Nieuwenhoven ◽  
L. Wieten ◽  
P. Boer ◽  
T. Diekman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

scholarly journals Connective tissue growth factor induction in a pressure-overloaded heart ameliorated by the angiotensin II type 1 receptor blocker olmesartan

2010 ◽  
Vol 33 (12) ◽  
pp. 1305-1311 ◽  
Author(s):  
Mutsumi Iwamoto ◽  
Satoshi Hirohata ◽  
Hiroko Ogawa ◽  
Takashi Ohtsuki ◽  
Ryoko Shinohata ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Receptor Blocker
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