scholarly journals Mouse Models of Type 1 and Type 2 Diabetes Derived from the Same Closed Colony: Genetic Susceptibility Shared Between Two Types of Diabetes

ILAR Journal ◽  
2004 ◽  
Vol 45 (3) ◽  
pp. 268-277 ◽  
Author(s):  
H. Ikegami ◽  
T. Fujisawa ◽  
T. Ogihara
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Susceptibility ◽  
Mouse Models ◽  
Closed Colony

scholarly journals Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189

Diabetes ◽  
2019 ◽  
Vol 68 (11) ◽  
pp. 2143-2154 ◽  
Author(s):  
Corinne G. Jolivalt ◽  
Alexandra Marquez ◽  
David Quach ◽  
Michelle C. Navarro Diaz ◽  
Carlos Anaya ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Mouse Models

scholarly journals Hair corticosterone measurement in mouse models of type 1 and type 2 diabetes mellitus

2017 ◽  
Vol 178 ◽  
pp. 166-171 ◽  
Author(s):  
Rebecca L. Erickson ◽  
Caroline A. Browne ◽  
Irwin Lucki
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Models

scholarly journals Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

Endocrinology ◽  
2009 ◽  
Vol 150 (12) ◽  
pp. 5294-5301 ◽  
Author(s):  
Bhumsoo Kim ◽  
Carey Backus ◽  
SangSu Oh ◽  
John M. Hayes ◽  
Eva L. Feldman
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Models ◽  
The United States ◽  
Tau Phosphorylation ◽  
Age Related ◽  
Increased Risk ◽  
And Gender ◽  
Tau Cleavage

Abstract As the population of the United States ages, the incidence of age-related neurodegenerative and systemic diseases including Alzheimer’s disease (AD) and diabetes is increasing rapidly. Multiple studies report that patients with diabetes have a 50–75% increased risk of developing AD compared with age- and gender-matched patients without diabetes. Abnormally phosphorylated tau is a major building block of neurofibrillary tangles, a classic neuropathological characteristic of AD. In addition, proteolytic tau cleavage promotes AD progression due to cleaved tau serving as a nucleation center for the pathological assembly of tau filaments. The current study examines tau modification in type 1 (streptozotocin-injected) and type 2 (db/db) mouse models of diabetes. Tau phosphorylation is increased in the cortex and hippocampus of db/db mice compared with db+ control mouse brain. Interestingly, there is an age-dependent increase in tau cleavage that is not observed in age-matched control db+ animals. Streptozotocin injection also increased tau phosphorylation; however, the increase was less significant compared with the type 2 mouse model, and more importantly, no tau cleavage was detected. Our results suggest tau modification caused by insulin dysfunction and hyperglycemia may contribute to the increased incidence of AD in diabetes. We hypothesize that type 1 and type 2 diabetes may contribute to AD through different mechanisms; in type 2 diabetes, hyperglycemia-mediated tau cleavage may be the key feature, whereas insulin deficiency may be the major contributing factor in type 1 diabetes.

scholarly journals Increased Recruitment but Impaired Function of Leukocytes during Inflammation in Mouse Models of Type 1 and Type 2 Diabetes

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22480 ◽  
Author(s):  
Ulrika Sofia Pettersson ◽  
Gustaf Christoffersson ◽  
Sara Massena ◽  
David Ahl ◽  
Leif Jansson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Models ◽  
Impaired Function
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