scholarly journals Tissue‐specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models

2021 ◽  
Author(s):  
Noah Moruzzi ◽  
Francesca Lazzeri‐Barcelo ◽  
Ismael Valladolid‐Acebes ◽  
Tilo Moede ◽  
Meike Paschen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Receptor ◽  
Mouse Models ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Receptor Isoforms ◽  
Insulin Receptor Isoforms ◽  
Diabetes Mouse

scholarly journals Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Cell ◽  
1999 ◽  
Vol 96 (3) ◽  
pp. 329-339 ◽  
Author(s):  
Rohit N Kulkarni ◽  
Jens C Brüning ◽  
Jonathon N Winnay ◽  
Catherine Postic ◽  
Mark A Magnuson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Receptor ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Tissue Specific

Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein

1994 ◽  
Vol 31 (2) ◽  
pp. 59-65 ◽  
Author(s):  
G. Sesti ◽  
A. N. Tullio ◽  
R. D'Alfonso ◽  
M. L. Napolitano ◽  
M. A. Marini ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Human Insulin ◽  
Receptor Protein ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Human Insulin Receptor ◽  
Alternatively Spliced

scholarly journals Tissue-Specific Expression of Two Alternatively Spliced Insulin Receptor mRNAs in Man

1989 ◽  
Vol 3 (8) ◽  
pp. 1263-1269 ◽  
Author(s):  
David E. Moller ◽  
Atsushi Yokota ◽  
Jose F. Caro ◽  
Jeffrey S. Flier
Keyword(s):  
Insulin Receptor ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Alternatively Spliced ◽  
Receptor Mrnas

scholarly journals Monoclonal therapy against calcitonin gene-related peptide lowers hyperglycemia and adiposity in type 2 diabetes mouse models

2020 ◽  
Vol 8 ◽  
pp. 100060
Author(s):  
Jonathan Halloran ◽  
Alexandre Lalande ◽  
Mandy Zang ◽  
Harshita Chodavarapu ◽  
Céline E. Riera
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Models ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Diabetes Mouse

scholarly journals The Genetics ofPTPN1and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Ryan C. Tsou ◽  
Kendra K. Bence
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Models ◽  
Tyrosine Phosphatase ◽  
Negative Regulator ◽  
Human Populations ◽  
Tissue Specific ◽  
Promising Therapeutic Target ◽  
Chromosome 20Q13 ◽  
Diabetes And Obesity

The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and energy expenditure. Due to its prominent role in regulating metabolism, PTP1B is a promising therapeutic target for the treatment of human obesity and type 2 diabetes. The PTP1B protein is encoded by thePTPN1gene on human chromosome 20q13, a region that shows linkage with insulin resistance, type 2 diabetes, and obesity in human populations. In this paper, we summarize the genetics of thePTPN1locus and associations with metabolic disease. In addition, we discuss the tissue-specific functions of PTP1B as gleaned from genetic mouse models.

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