PIN Diode-Triode with Embedded Gate-Control Potential Barrier: Surface Charge Effects

Author(s):  
Dmitry Dyubo ◽  
Oleg Yu. Tsybin
Biosensors ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 397
Author(s):  
Dmitry Dyubo ◽  
Oleg Yu. Tsybin

The ionized states of molecular analytes located on solid surfaces require profound investigation and better understanding for applications in the basic sciences in general, and in the design of nanobiosensors, in particular. Such ionized states are induced by the interactions of molecules between them in the analyzed substance and with the target surface. Here, computer simulations using COMSOL Multiphysics software show the effect of surface charge density and distribution on the output generation in a dynamic PIN diode with gate control. This device, having built-in potential barriers, has a unique internal integration of output signal generation. The identified interactions showed the possibility of a new design for implementing a nanobiosensor based on a dynamic PIN diode in a mode with surface charge control.


2021 ◽  
pp. 2101549
Author(s):  
Anna R. Ziefuss ◽  
Torben Steenbock ◽  
Dominik Benner ◽  
Anton Plech ◽  
Jörg Göttlicher ◽  
...  

2019 ◽  
Vol 91 (9) ◽  
pp. 5530-5536 ◽  
Author(s):  
Je Hyun Bae ◽  
Dengchao Wang ◽  
Keke Hu ◽  
Michael V. Mirkin

Small ◽  
2010 ◽  
Vol 6 (22) ◽  
pp. 2590-2597 ◽  
Author(s):  
Andreas Riedinger ◽  
Feng Zhang ◽  
Fabian Dommershausen ◽  
Carlheinz Röcker ◽  
Stefan Brandholt ◽  
...  

2005 ◽  
Vol 125 (5) ◽  
pp. 493-503 ◽  
Author(s):  
Nazzareno D'Avanzo ◽  
Hee Cheol Cho ◽  
Illya Tolokh ◽  
Roman Pekhletski ◽  
Igor Tolokh ◽  
...  

Ion channel conductance can be influenced by electrostatic effects originating from fixed “surface” charges that are remote from the selectivity filter. To explore whether surface charges contribute to the conductance properties of Kir2.1 channels, unitary conductance was measured in cell-attached recordings of Chinese hamster ovary (CHO) cells transfected with Kir2.1 channels over a range of K+ activities (4.6–293.5 mM) using single-channel measurements as well as nonstationary fluctuation analysis for low K+ activities. K+ ion concentrations were shown to equilibrate across the cell membrane in our studies using the voltage-sensitive dye DiBAC4(5). The dependence of γ on the K+ activity (aK) was fit well by a modified Langmuir binding isotherm, with a nonzero intercept as aK approaches 0 mM, suggesting electrostatic surface charge effects. Following the addition of 100 mM N-methyl-d-glucamine (NMG+), a nonpermeant, nonblocking cation or following pretreatment with 50 mM trimethyloxonium (TMO), a carboxylic acid esterifying agent, the γ–aK relationship did not show nonzero intercepts, suggesting the presence of surface charges formed by glutamate or aspartate residues. Consistent with surface charges in Kir2.1 channels, the rates of current decay induced by Ba2+ block were slowed with the addition of NMG or TMO. Using a molecular model of Kir2.1 channels, three candidate negatively charged residues were identified near the extracellular mouth of the pore and mutated to cysteine (E125C, D152C, and E153C). E153C channels, but not E125C or D152C channels, showed hyperbolic γ–aK relationships going through the origin. Moreover, the addition of MTSES to restore the negative charges in E53C channels reestablished wild-type conductance properties. Our results demonstrate that E153 contributes to the conductance properties of Kir2.1 channels by acting as a surface charge.


1992 ◽  
Vol 261 ◽  
Author(s):  
Piotr Edelman ◽  
Jacek Lagowski ◽  
Lubek Jastrzebski

ABSTRACTWe present fast, wafer-scale imaging of the surface charge achieved via non-contact measurement of the surface potential barrier by surface photovoltage (SPV) under high excitation levels. The approach is capable of resolving surface charge differences as small as 108 q/cm2. Fundamentals of surface charge imaging are discussed, and the method is compared with standard SPV contamination mapping. Examples include problems relevant to silicon IC fabrication and surface charge maps of GaAs and InP.


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