Effective Detection of Phenylalanine Using Pyridine Based Sensor

Pyridine based organic fluorophore has been synthesized for the detection of phenylalanine (PA). The quenching has been observed between fluorophore and PA through ICT system as noticed by colorimetric and fluorimetric techniques. Under optimized conditions, the fluorophore detects PA selectively in the presence of other biomolecules. The practical application of the fluorophore has been successfully applied in human blood serum and urine.

Thermal equilibration between singlet and triplet excited states in organic fluorophore for submicrosecond delayed fluorescence

In any complex molecular system, electronic excited states with different spin multiplicities can be described via a simple statistical thermodynamic formalism if the states are in thermal equilibrium. However, this ideal situation has hitherto been infeasible for efficient fluorescent organic molecules. Here, we report a highly emissive metal-free purely organic fluorophore that enables thermal equilibration between singlet and triplet excited states. The key to this unconventional excitonic behavior is the exceptionally fast spin-flipping reverse intersystem crossing from the triplet to singlet excited states with a rate constant exceeding 108 per second, which is considerably higher than that of radiative decay (fluorescence) from the singlet excited state. The present fluorophoric system exhibits an emission lifetime as short as 750 nanoseconds and, therefore, allows organic light-emitting diodes to demonstrate external electroluminescence quantum efficiency exceeding 20% even at a practical high luminance of more than 10,000 candelas per square meter.

Mannose modified zwitterionic polyester conjugated second near-infrared organic fluorophore for targeted photothermal therapy

Cancer resistance has been the huge challenge to clinical treatment. Photothermal therapy of second near-infrared (NIR-II) organic dye small molecule has been used to conquer cancer resistance. However, the available...

Functionalized naphthalenediimides based supramolecular charge–transfer complexes via self-assembly and their photophysical properties†

We report here the design and syntheses of a naphthalenediimide (NDI)-N functionalized organic fluorophore, 1 and its supramolecular CT complexes [(1∙2H)2+·(PA–)2] (2) and [(1∙2H)2+·(3,5-DNSA–)2] (3), self-assembled from 1 as an...

LIVE-PAINT: Super-Resolution Microscopy Inside Live Cells Using Reversible Peptide-Protein Interactions

We present LIVE-PAINT, a new approach to super-resolution fluorescent imaging inside live cells. In LIVE-PAINT only a short peptide sequence is fused to the protein being studied, unlike conventional super-resolution methods, which rely on directly fusing the biomolecule of interest to a large fluorescent protein, organic fluorophore, or oligonucleotide. LIVE-PAINT works by observing the blinking of localized fluorescence as this peptide is reversibly bound by a protein that is fused to a fluorescent protein. We have demonstrated the effectiveness of LIVE-PAINT by imaging a number of different proteins inside live S. cerevisiae. Not only is LIVE-PAINT widely applicable, easily implemented, and the modifications minimally perturbing, but we also anticipate it will extend data acquisition times compared to those previously possible with methods that involve direct fusion to a fluorescent protein.

Oxidative alkylation of alkenes with carbonyl compounds through concomitant 1,2-aryl migration by photoredox catalysis

An efficient protocol for the construction of 1,5-diketones was realized in the presence of organic fluorophore 4CzIPN, diaryliodonium salt, and visible light irradiation.