scholarly journals Thermopneumatic suction integrated microfluidic blood analysis system

2018 ◽  
Author(s):  
Chiao-Hsun Yang ◽  
Yu-Ling Hsieh ◽  
Ping-Hsien Tsou ◽  
Bor-Ran Li
Keyword(s):  
High Efficiency ◽  
Point Of Care ◽  
Cost Effective ◽  
Blood Analysis ◽  
Separation Device ◽  
Blood Separation ◽  
Blood Tests ◽  
Key Factor ◽  
Rate Design ◽  
Analysis System

AbstractBlood tests provide crucial diagnostic information regarding several diseases. A key factor that affects the precision and accuracy of blood tests is the interference of red blood cells; however, the conventional methods of blood separation are often complicated and time consuming. In this study, we devised a simple but high-efficiency blood separation system on a self-strained microfluidic device that separates 99.7% of the plasma in only 6 min. Parameters, such as flow rate, design of the filter trench, and the relative positions of the filter trench and channel, were optimized through microscopic monitoring. Moreover, this air-difference-driven device uses a cost-effective and easy-to-use heater strip that creates a low-pressure environment in the microchannel within minutes. With the aforementioned advantages, this blood separation device could be another platform choice for point-of-care testing.

Performance evaluation of the epoc® point-of-care blood analysis system

2015 ◽  
Vol 48 (15) ◽  
pp. 1013
Author(s):  
Yu Chen ◽  
Monique Gorman ◽  
Bill O'Reilly
Keyword(s):  
Performance Evaluation ◽  
Point Of Care ◽  
Blood Analysis ◽  
Analysis System

scholarly journals High-Efficiency Plasma Separator Based on Immunocapture and Filtration

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 352
Author(s):  
Xiaosong Su ◽  
Jianzhong Zhang ◽  
Dongxu Zhang ◽  
Yingbin Wang ◽  
Mengyuan Chen ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Blood Sample ◽  
High Efficiency ◽  
Separation Efficiency ◽  
Point Of Care ◽  
Cost Effective ◽  
Plasma Separation ◽  
Centrifuge Method ◽  
Purification Membranes ◽  
Whole Blood Sample

The shortcomings of standard plasma-separation methods limit the point-of-care application of microfluidics in clinical facilities and at the patient’s bedside. To overcome the limitations of this inconvenient, laborious, and costly technique, a new plasma-separation technique and device were developed. This new separation method relies on immunological capture and filtration to exclude cells from plasma, and is convenient, easy to use, and cost-effective. Most of the RBCs can be captured and immobilized by antibody which coated in separation matrix, and residue cells can be totally removed from the sample by a commercially plasma purification membranes. A 400 µL anti-coagulated whole blood sample with 65% hematocrit (Hct) can be separated by the device in 5 min with only one pipette. Up to 97% of the plasma can be recovered from the raw blood sample with a separation efficiency at 100%. The recovery rate of small molecule compounds, proteins, and nucleic acid biomarkers is evaluated; there are no obvious differences from the centrifuge method. The results demonstrate that this method is an excellent replacement for traditional plasma preparation protocols.

Clinical experience with the Diametrics IRMA (Immediate Response Mobile Analysis) blood analysis system

Perfusion ◽  
1997 ◽  
Vol 12 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Kelly D Hedlund ◽  
Scott Oen ◽  
Leo LaFauce ◽  
D Michael Sanford
Keyword(s):  
Quality Control ◽  
Point Of Care ◽  
Blood Analysis ◽  
Testing Device ◽  
Excellent Correlation ◽  
Point Of Care Testing ◽  
Control Solution ◽  
Ann Arbor ◽  
Analysis System ◽  
Immediate Response

The Immediate Response Mobile Analysis (IRMA) blood analysis system (Diametrics Medical Incorporated, St Paul, MN, USA) is a new point-of-care testing device that uses technology similar to the Gem Premier (Mallinckrodt Sensor Systems Incorporated, Ann Arbor, MI, USA), which are ion-specific electrodes. We compared these two analysers using both patient blood samples ( n = 50) and aqueous quality control solutions ( n = 45). Linear regression (Pearson product-moment correlation coefficient) was performed to quantify the strength of the association between results. In addition, bias and precision were determined in accordance with the method described by Bland and Altman.1 The results demonstrated excellent correlation between the IRMA and the Gem Premier, and bias and precision were acceptable for both patient and quality control samples. Reproducibility of results was also assessed using one level of aqueous quality control solution ( n = 50). The IRMA demonstrated very little variance in parameter readings over a five-day study period.

Blood Analysis Requests of Patients’ and Clinical Reflections in Primary Care

2020 ◽  
Vol 9 (2) ◽  
pp. 96-102
Author(s):  
Zerrin Gamsizkan ◽  
Mehmet Ali Sungur ◽  
Yasemin Çayır
Keyword(s):  
Chronic Disease ◽  
Blood Test ◽  
Family Health ◽  
Cross Sectional Study ◽  
Blood Analysis ◽  
Primary Role ◽  
Cross Sectional ◽  
High Expectations ◽  
Blood Tests ◽  
Study Results

Aim: The aim of the study is to determine the factors that may affect the demands of patients who come with the request to have a blood test without any chronic disease or a planned examination check. Methods: The data of this descriptive, cross-sectional study, were collected with a questionnaire that was prepared to examine the opinions of the patients who claim to have a blood test by coming to the family health center without any complaints. Patients over 18 years of age, who did not have any chronic disease and had no scheduled examination appointments were included in the study. Results: A total of 278 patients who wanted to have a blood test within the 6-months period were included in the study. Female patients who wanted to have a blood test were significantly more than male patients. When we look at the causes of patients who wanted to have a blood test; 61.2% (n=170) patients stated that they are concerned about their health and 6.1% (n=17) stated that they were affected by media warnings. There was no significant relationship between the frequency of blood test requests of patients and their age, gender, education, and general health status. Conclusion: Patients with high expectations and anxiety may be more willing to perform blood tests at inappropriate intervals. Family physicians, whose primary role is preventive medicine, have consultancy and information duties in order to protect their patients from the risk of over-examination and diagnosis. Keywords: blood tests, patient, screening, routine diagnostic tests

Trends in Diagnosis for Active Tuberculosis Using Nanomaterials

2019 ◽  
Vol 26 (11) ◽  
pp. 1946-1959 ◽  
Author(s):  
Le Minh Tu Phan ◽  
Lemma Teshome Tufa ◽  
Hwa-Jung Kim ◽  
Jaebeom Lee ◽  
Tae Jung Park
Keyword(s):  
Sensitivity And Specificity ◽  
High Efficiency ◽  
Point Of Care ◽  
High Sensitivity ◽  
Signs And Symptoms ◽  
Diagnostic Methods ◽  
Advantages And Disadvantages ◽  
Treatment And Prevention ◽  
Clinical Tools ◽  
Diagnostic Applications

Background:Tuberculosis (TB), one of the leading causes of death worldwide, is difficult to diagnose based only on signs and symptoms. Methods for TB detection are continuously being researched to design novel effective clinical tools for the diagnosis of TB.Objective:This article reviews the methods to diagnose TB at the latent and active stages and to recognize prospective TB diagnostic methods based on nanomaterials.Methods:The current methods for TB diagnosis were reviewed by evaluating their advantages and disadvantages. Furthermore, the trends in TB detection using nanomaterials were discussed regarding their performance capacity for clinical diagnostic applications.Results:Current methods such as microscopy, culture, and tuberculin skin test are still being employed to diagnose TB, however, a highly sensitive point of care tool without false results is still needed. The utilization of nanomaterials to detect the specific TB biomarkers with high sensitivity and specificity can provide a possible strategy to rapidly diagnose TB. Although it is challenging for nanodiagnostic platforms to be assessed in clinical trials, active TB diagnosis using nanomaterials is highly expected to achieve clinical significance for regular application. In addition, aspects and future directions in developing the high-efficiency tools to diagnose active TB using advanced nanomaterials are expounded.Conclusion:This review suggests that nanomaterials have high potential as rapid, costeffective tools to enhance the diagnostic sensitivity and specificity for the accurate diagnosis, treatment, and prevention of TB. Hence, portable nanobiosensors can be alternative effective tests to be exploited globally after clinical trial execution.

scholarly journals Paper-based analytical devices for point-of-care blood tests

2021 ◽  
Vol 15 (4) ◽  
pp. 041303
Author(s):  
Hao Yuan ◽  
Ping-Yeh Chiu ◽  
Chien-Fu Chen
Keyword(s):  
Point Of Care ◽  
Blood Tests
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