scholarly journals Isolation of camptothecin-sensitive Chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group

Mutagenesis ◽  
2000 ◽  
Vol 15 (4) ◽  
pp. 367-374 ◽  
Author(s):  
M. A. Johnson
Keyword(s):  
Ataxia Telangiectasia ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group ◽  
Phenotypic Heterogeneity

Phenotypic heterogeneity within the first complementation group of UV-sensitive mutants of Chinese hamster cell lines

1988 ◽  
Vol 193 (1) ◽  
pp. 31-41 ◽  
Author(s):  
Małgorzata Z. Zdzienicka ◽  
G.P. van der Schans ◽  
A. Westerveld ◽  
A.A. van Zeeland ◽  
J.W.I.M. Simons
Keyword(s):  
Cell Lines ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group ◽  
Phenotypic Heterogeneity

Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: A new complementation group with chromosomal instability

1993 ◽  
Vol 19 (5) ◽  
pp. 431-437 ◽  
Author(s):  
W. J. I. Overkamp ◽  
M. A. Rooimans ◽  
I. Neuteboom ◽  
P. Telleman ◽  
F. Arwert ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Mitomycin C ◽  
Chromosomal Instability ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group

scholarly journals Identification and characterization of a third complementation group of emetine-resistant Chinese hamster cell mutants.

1981 ◽  
Vol 1 (1) ◽  
pp. 58-65 ◽  
Author(s):  
J J Wasmuth ◽  
J M Hill ◽  
L S Vock
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Resistant Cell ◽  
Complementation Group ◽  
Ovary Cells ◽  
Complementation Groups ◽  
Resistant Mutants ◽  
Biosynthetic Machinery

We have isolated emetine-resistant cell lines from Chinese hamster peritoneal fibroblasts and have shown that they represent a third distinct class or complementation group of emetine-resistant mutants, as determined by three different criteria. These mutants, like those belonging to the two other complementation groups we have previously defined, which were isolated from Chinese hamster lung and Chinese hamster ovary cells, have alterations that directly affect the protein biosynthetic machinery. So far, there is absolute cell line specificity with respect to the three complementation groups, in that all the emetine-resistant mutants we have isolated from Chinese hamster lung cells belong to one complementation group, all those we have isolated from Chinese hamster ovary cells belong to a second complementation group, and all those isolated from Chinese hamster peritoneal cells belong to a third complementation group. Thus, in cultured Chinese hamster cells, mutations in at least three different loci, designated emtA, emtB, and emtC, encoding for different components of the protein biosynthetic machinery, can give rise to the emetine-resistant phenotype.

The Chinese hamster cell mutant V-H4 is homologous to Fanconi anemia (complementation group A)

1991 ◽  
Vol 56 (1) ◽  
pp. 23-26 ◽  
Author(s):  
F. Arwert ◽  
M.A. Rooimans ◽  
A. Westerveld ◽  
J.W.I.M. Simons ◽  
M.Z. Zdzienicka
Keyword(s):  
Fanconi Anemia ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group ◽  
Cell Mutant ◽  
Group A

Human chromosome 11 complements ataxia-telangiectasia cells but does not complement the defect in AT-like Chinese hamster cell mutants

1993 ◽  
Vol 92 (3) ◽  
Author(s):  
W. Jongmans ◽  
J. Wiegant ◽  
M. Oshimura ◽  
M.R. James ◽  
P.H.M. Lohman ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Ataxia Telangiectasia ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Chromosome 11

DNA repair characteristics and mutability of the UV-sensitive V79 Chinese hamster cell mutant V-B11 (complementation group 7)

Mutagenesis ◽  
1991 ◽  
Vol 6 (3) ◽  
pp. 179-183 ◽  
Author(s):  
M.Z. Zdzienicka ◽  
D.L. Mitchell ◽  
J. Venema ◽  
A. van Hoffen ◽  
A.A. van Zeeland ◽  
...  
Keyword(s):  
Dna Repair ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group ◽  
Cell Mutant

Cellular characteristics of Chinese hamster cell mutants resembling ataxia telangiectasia cells

1993 ◽  
Vol 294 (3) ◽  
pp. 207-214 ◽  
Author(s):  
W. Jongmans ◽  
G.W.C.T. Verhaegh ◽  
K. Sankaranaryanan ◽  
P.H.M. Lohman ◽  
M.Z. Zdzienicka
Keyword(s):  
Ataxia Telangiectasia ◽  
Chinese Hamster ◽  
Chinese Hamster Cell

Identification and characterization of a third complementation group of emetine-resistant Chinese hamster cell mutants

1981 ◽  
Vol 1 (1) ◽  
pp. 58-65
Author(s):  
J J Wasmuth ◽  
J M Hill ◽  
L S Vock
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Resistant Cell ◽  
Complementation Group ◽  
Ovary Cells ◽  
Complementation Groups ◽  
Resistant Mutants ◽  
Biosynthetic Machinery

We have isolated emetine-resistant cell lines from Chinese hamster peritoneal fibroblasts and have shown that they represent a third distinct class or complementation group of emetine-resistant mutants, as determined by three different criteria. These mutants, like those belonging to the two other complementation groups we have previously defined, which were isolated from Chinese hamster lung and Chinese hamster ovary cells, have alterations that directly affect the protein biosynthetic machinery. So far, there is absolute cell line specificity with respect to the three complementation groups, in that all the emetine-resistant mutants we have isolated from Chinese hamster lung cells belong to one complementation group, all those we have isolated from Chinese hamster ovary cells belong to a second complementation group, and all those isolated from Chinese hamster peritoneal cells belong to a third complementation group. Thus, in cultured Chinese hamster cells, mutations in at least three different loci, designated emtA, emtB, and emtC, encoding for different components of the protein biosynthetic machinery, can give rise to the emetine-resistant phenotype.

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