Human chromosome 11 complements ataxia-telangiectasia cells but does not complement the defect in AT-like Chinese hamster cell mutants

1993 ◽  
Vol 92 (3) ◽  
Author(s):  
W. Jongmans ◽  
J. Wiegant ◽  
M. Oshimura ◽  
M.R. James ◽  
P.H.M. Lohman ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Ataxia Telangiectasia ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Chromosome 11

Cellular characteristics of Chinese hamster cell mutants resembling ataxia telangiectasia cells

1993 ◽  
Vol 294 (3) ◽  
pp. 207-214 ◽  
Author(s):  
W. Jongmans ◽  
G.W.C.T. Verhaegh ◽  
K. Sankaranaryanan ◽  
P.H.M. Lohman ◽  
M.Z. Zdzienicka
Keyword(s):  
Ataxia Telangiectasia ◽  
Chinese Hamster ◽  
Chinese Hamster Cell

Replication timing in a single human chromosome 11 transferred into the Chinese hamster ovary (CHO) cell line

Gene ◽  
2012 ◽  
Vol 510 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Yoshihisa Watanabe ◽  
Yasuhiro Kazuki ◽  
Mitsuo Oshimura ◽  
Toshimichi Ikemura ◽  
Masato Maekawa
Keyword(s):  
Human Chromosome ◽  
Cell Line ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster ◽  
Replication Timing ◽  
Chromosome 11 ◽  
Cho Cell ◽  
Cho Cell Line

2,4-Dichlorophenol and MCPA in a V79 Test

1988 ◽  
Vol 15 (3) ◽  
pp. 245-250
Author(s):  
Geirid Fiskesjö
Keyword(s):  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Test System ◽  
Similar Degree ◽  
Human Beings ◽  
Industrial Chemicals ◽  
Allium Test ◽  
Chinese Hamster Cell Line ◽  
A Cell ◽  
Mutagenic Effects

Two industrial chemicals, 2,4-dichlorophenol and 4-chloro-2-methylphenoxyacetic acid (MCPA), which have no toxic effects on the Chinese hamster cell line V79 alone, were tested for toxicity and mutagenicity in a cell-mediated test, where mixed-function oxidase (MFO) enzymes are active in the metabolism of xenobiotics. For 2,4-dichlorophenol, a dose-dependent toxicity as well as a slight mutagenicity could be shown when oxygenation enzymes were present. A similar degree of toxicity in a plant test system (the Allium test) indicates a similar risk of damage from exposure to dichlorophenol treatments in both these systems. MCPA did not induce any toxic or mutagenic effects at the concentrations tested. These results were not in agreement with previous results in plant material, where MCPA was clearly toxic at relatively low doses. However, since chlorophenols have been found in plants sprayed with phenoxyacetic acids, further investigations should be performed concerning potential risk to human beings.

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