Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: A new complementation group with chromosomal instability

1993 ◽  
Vol 19 (5) ◽  
pp. 431-437 ◽  
Author(s):  
W. J. I. Overkamp ◽  
M. A. Rooimans ◽  
I. Neuteboom ◽  
P. Telleman ◽  
F. Arwert ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Mitomycin C ◽  
Chromosomal Instability ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group

Involvement of apoptosis in mitomycin C hypersensitivity of Chinese hamster cell mutants

2000 ◽  
Vol 59 (9) ◽  
pp. 1101-1107 ◽  
Author(s):  
Efterpi Papouli ◽  
Corinne Lafon ◽  
Annie Valette ◽  
Malgorzata Z Zdzienicka ◽  
Martine Defais ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Chinese Hamster ◽  
Chinese Hamster Cell

scholarly journals Identification and characterization of a third complementation group of emetine-resistant Chinese hamster cell mutants.

1981 ◽  
Vol 1 (1) ◽  
pp. 58-65 ◽  
Author(s):  
J J Wasmuth ◽  
J M Hill ◽  
L S Vock
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Resistant Cell ◽  
Complementation Group ◽  
Ovary Cells ◽  
Complementation Groups ◽  
Resistant Mutants ◽  
Biosynthetic Machinery

We have isolated emetine-resistant cell lines from Chinese hamster peritoneal fibroblasts and have shown that they represent a third distinct class or complementation group of emetine-resistant mutants, as determined by three different criteria. These mutants, like those belonging to the two other complementation groups we have previously defined, which were isolated from Chinese hamster lung and Chinese hamster ovary cells, have alterations that directly affect the protein biosynthetic machinery. So far, there is absolute cell line specificity with respect to the three complementation groups, in that all the emetine-resistant mutants we have isolated from Chinese hamster lung cells belong to one complementation group, all those we have isolated from Chinese hamster ovary cells belong to a second complementation group, and all those isolated from Chinese hamster peritoneal cells belong to a third complementation group. Thus, in cultured Chinese hamster cells, mutations in at least three different loci, designated emtA, emtB, and emtC, encoding for different components of the protein biosynthetic machinery, can give rise to the emetine-resistant phenotype.

The Chinese hamster cell mutant V-H4 is homologous to Fanconi anemia (complementation group A)

1991 ◽  
Vol 56 (1) ◽  
pp. 23-26 ◽  
Author(s):  
F. Arwert ◽  
M.A. Rooimans ◽  
A. Westerveld ◽  
J.W.I.M. Simons ◽  
M.Z. Zdzienicka
Keyword(s):  
Fanconi Anemia ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group ◽  
Cell Mutant ◽  
Group A

Phenotypic heterogeneity within the first complementation group of UV-sensitive mutants of Chinese hamster cell lines

1988 ◽  
Vol 193 (1) ◽  
pp. 31-41 ◽  
Author(s):  
Małgorzata Z. Zdzienicka ◽  
G.P. van der Schans ◽  
A. Westerveld ◽  
A.A. van Zeeland ◽  
J.W.I.M. Simons
Keyword(s):  
Cell Lines ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group ◽  
Phenotypic Heterogeneity

DNA repair characteristics and mutability of the UV-sensitive V79 Chinese hamster cell mutant V-B11 (complementation group 7)

Mutagenesis ◽  
1991 ◽  
Vol 6 (3) ◽  
pp. 179-183 ◽  
Author(s):  
M.Z. Zdzienicka ◽  
D.L. Mitchell ◽  
J. Venema ◽  
A. van Hoffen ◽  
A.A. van Zeeland ◽  
...  
Keyword(s):  
Dna Repair ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group ◽  
Cell Mutant

Identification and characterization of a third complementation group of emetine-resistant Chinese hamster cell mutants

1981 ◽  
Vol 1 (1) ◽  
pp. 58-65
Author(s):  
J J Wasmuth ◽  
J M Hill ◽  
L S Vock
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Resistant Cell ◽  
Complementation Group ◽  
Ovary Cells ◽  
Complementation Groups ◽  
Resistant Mutants ◽  
Biosynthetic Machinery

We have isolated emetine-resistant cell lines from Chinese hamster peritoneal fibroblasts and have shown that they represent a third distinct class or complementation group of emetine-resistant mutants, as determined by three different criteria. These mutants, like those belonging to the two other complementation groups we have previously defined, which were isolated from Chinese hamster lung and Chinese hamster ovary cells, have alterations that directly affect the protein biosynthetic machinery. So far, there is absolute cell line specificity with respect to the three complementation groups, in that all the emetine-resistant mutants we have isolated from Chinese hamster lung cells belong to one complementation group, all those we have isolated from Chinese hamster ovary cells belong to a second complementation group, and all those isolated from Chinese hamster peritoneal cells belong to a third complementation group. Thus, in cultured Chinese hamster cells, mutations in at least three different loci, designated emtA, emtB, and emtC, encoding for different components of the protein biosynthetic machinery, can give rise to the emetine-resistant phenotype.

2,4-Dichlorophenol and MCPA in a V79 Test

1988 ◽  
Vol 15 (3) ◽  
pp. 245-250
Author(s):  
Geirid Fiskesjö
Keyword(s):  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Test System ◽  
Similar Degree ◽  
Human Beings ◽  
Industrial Chemicals ◽  
Allium Test ◽  
Chinese Hamster Cell Line ◽  
A Cell ◽  
Mutagenic Effects

Two industrial chemicals, 2,4-dichlorophenol and 4-chloro-2-methylphenoxyacetic acid (MCPA), which have no toxic effects on the Chinese hamster cell line V79 alone, were tested for toxicity and mutagenicity in a cell-mediated test, where mixed-function oxidase (MFO) enzymes are active in the metabolism of xenobiotics. For 2,4-dichlorophenol, a dose-dependent toxicity as well as a slight mutagenicity could be shown when oxygenation enzymes were present. A similar degree of toxicity in a plant test system (the Allium test) indicates a similar risk of damage from exposure to dichlorophenol treatments in both these systems. MCPA did not induce any toxic or mutagenic effects at the concentrations tested. These results were not in agreement with previous results in plant material, where MCPA was clearly toxic at relatively low doses. However, since chlorophenols have been found in plants sprayed with phenoxyacetic acids, further investigations should be performed concerning potential risk to human beings.

Sign in / Sign up

Export Citation Format

Share Document