The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy

Brain ◽  
1995 ◽  
Vol 118 (1) ◽  
pp. 105-118 ◽  
Author(s):  
Gary W. Mathern ◽  
Thomas L. Babb ◽  
Barbara G. Vickrey ◽  
Maria Melendez ◽  
James K. Pretorius
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Hippocampal Neuron ◽  
Neuron Loss ◽  
Pathogenic Mechanisms

scholarly journals Temporal lobe epilepsy patients with severe hippocampal neuron loss but normal hippocampal volume: Extracellular matrix molecules are important for the maintenance of hippocampal volume

Epilepsia ◽  
2015 ◽  
Vol 56 (10) ◽  
pp. 1562-1570 ◽  
Author(s):  
Jose Eduardo Peixoto-Santos ◽  
Tonicarlo Rodrigues Velasco ◽  
Orfa Yineth Galvis-Alonso ◽  
David Araujo ◽  
Ludmyla Kandratavicius ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Neuron ◽  
Hippocampal Volume ◽  
Neuron Loss ◽  
Extracellular Matrix Molecules

scholarly journals Long-term surgical outcomes of temporal lobe epilepsy associated with low-grade brain tumors

Cancer ◽  
2009 ◽  
Vol 115 (24) ◽  
pp. 5771-5779 ◽  
Author(s):  
Ji Hoon Phi ◽  
Seung-Ki Kim ◽  
Byung-Kyu Cho ◽  
Seo Young Lee ◽  
Su Yeon Park ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Low Grade

scholarly journals Surgical Outcomes and EEG Prognostic Factors After Stereotactic Laser Amygdalohippocampectomy for Mesial Temporal Lobe Epilepsy

2021 ◽  
Vol 12 ◽  
Author(s):  
Shasha Wu ◽  
Naoum P. Issa ◽  
Maureen Lacy ◽  
David Satzer ◽  
Sandra L. Rose ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Mesial Temporal Lobe Epilepsy ◽  
Seizure Freedom ◽  
Seizure Recurrence ◽  
Factors Associated ◽  
Scalp Eeg ◽  
Mesial Temporal Lobe

Objective: To assess the seizure outcomes of stereotactic laser amygdalohippocampectomy (SLAH) in consecutive patients with mesial temporal lobe epilepsy (mTLE) in a single center and identify scalp EEG and imaging factors in the presurgical evaluation that correlate with post-surgical seizure recurrence.Methods: We retrospectively reviewed the medical and EEG records of 30 patients with drug-resistant mTLE who underwent SLAH and had at least 1 year of follow-up. Surgical outcomes were classified using the Engel scale. Univariate hazard ratios were used to evaluate the risk factors associated with seizure recurrence after SLAH.Results: The overall Engel class I outcome after SLAH was 13/30 (43%), with a mean postoperative follow-up of 48.9 ± 17.6 months. Scalp EEG findings of interictal regional slow activity (IRSA) on the side of surgery (HR = 4.05, p = 0.005) and non-lateralizing or contra-lateralizing seizure onset (HR = 4.31, p = 0.006) were negatively correlated with postsurgical seizure freedom. Scalp EEG with either one of the above features strongly predicted seizure recurrence after surgery (HR = 7.13, p < 0.001) with 100% sensitivity and 71% specificity.Significance: Understanding the factors associated with good or poor surgical outcomes can help choose the best candidates for SLAH. Of the variables assessed, scalp EEG findings were the most clearly associated with seizure outcomes after SLAH.

scholarly journals Intrinsic Thalamic Network in Temporal Lobe Epilepsy With Hippocampal Sclerosis According to Surgical Outcomes

2021 ◽  
Vol 12 ◽  
Author(s):  
Kyoo Ho Cho ◽  
Ho-Joon Lee ◽  
Kyoung Heo ◽  
Sung Eun Kim ◽  
Dong Ah Lee ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Hippocampal Sclerosis ◽  
Three Dimensional ◽  
Thalamic Nuclei ◽  
Characteristic Path Length ◽  
Ipsilateral Hemisphere ◽  
Hippocampal Subfields ◽  
Significant Difference

Background: The aim of this study was to identify the differences of intrinsic amygdala, hippocampal, or thalamic networks according to surgical outcomes in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS).Methods: We enrolled 69 pathologically confirmed TLE patients with HS. All patients had pre-operative three-dimensional T1-weighted MRI using a 3.0 T scanner. We obtained the structural volumes of the amygdala nuclei, hippocampal subfields, and thalamic nuclei. Then, we investigated the intrinsic networks based on volumes of these structures using structural covariance and graph theoretical analysis.Results: Of the 69 TLE patients with HS, 21 patients (42.1%) had poor surgical outcomes, whereas 40 patients (57.9%) had good surgical outcomes. The volumes in the amygdala nuclei, hippocampal subfields, and thalamic nuclei were not different according to surgical outcome. In addition, the intrinsic amygdala and hippocampal networks were not different between the patients with poor and good surgical outcomes. However, there was a significant difference in the intrinsic thalamic network in the ipsilateral hemisphere between them. The eccentricity and small-worldness index were significantly increased, whereas the characteristic path length was decreased in the patients with poor surgical outcomes compared to those with good surgical outcomes.Conclusion: We successfully demonstrated significant differences in the intrinsic thalamic network in the ipsilateral hemisphere between TLE patients with HS with poor and good surgical outcomes. This result suggests that the pre-operative intrinsic thalamic network can be related with surgical outcomes in TLE patients with HS.

Status Epilepticus-Induced Neurogenesis and Neuron Loss in the Kainate Model of Temporal Lobe Epilepsy

2003 ◽  
Vol 21 (2) ◽  
pp. 157-166
Author(s):  
Takashi Ninomiya ◽  
Kiyoshi Morimoto ◽  
Takemi Watanabe ◽  
Tohru Hirao ◽  
Osamu Yasuhara ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Neuron Loss

Letter to the Editor Regarding“Surgical Outcomes of Laser Interstitial Thermal Therapy for Temporal Lobe Epilepsy”

2020 ◽  
Vol 143 ◽  
pp. 626 ◽  
Author(s):  
Ravish R. Keni ◽  
William Andres Florez-Perdomo ◽  
Md Moshiur Rahman ◽  
Luis Rafael Moscote-Salazar ◽  
Amit Agrawal
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy ◽  
Letter To The Editor

Reduced glutamine synthetase in hippocampal areas with neuron loss in temporal lobe epilepsy

Neurology ◽  
2005 ◽  
Vol 64 (2) ◽  
pp. 326-333 ◽  
Author(s):  
W. S. van der Hel ◽  
R. G.E. Notenboom ◽  
I. W.M. Bos ◽  
P. C. van Rijen ◽  
C. W.M. van Veelen ◽  
...  
Keyword(s):  
Glutamine Synthetase ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Neuron Loss

scholarly journals P.035 Correlation of thalamic connectivity with the duration of epilepsy in patients with temporal lobe epilepsy

2017 ◽  
Vol 44 (S2) ◽  
pp. S22-S22
Author(s):  
B Santyr ◽  
JC Lau ◽  
SM Mirsattari ◽  
JG Burneo ◽  
S de Ribaupierre ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Parahippocampal Gyrus ◽  
Probabilistic Tractography ◽  
Temporal Lobes ◽  
Surgical Success ◽  
False Discovery ◽  
Long Duration ◽  
Temporal Neocortex

Background: Morphometry and connectivity studies targeting the thalamus have revealed specific patterns of atrophy and deafferentiation in patients with temporal lobe epilepsy (TLE). We used probabilistic tractography to investigate thalamic connectivity with respect to duration of epilepsy and surgical outcomes in TLE. Methods: Patients (N=20) with drug-resistant TLE (10 short duration (<15 years), 10 long duration (>15 years)) were scanned with multi-parametric 3T MRI and compared with 34 healthy controls. The Harvard-Oxford atlas was modified to create 14 target regions in the temporal lobes. Probabilistic tractography (FSL) was used to delineate thalamic sub-regions most connected to each target. The volume, mean T1, T2, FA and MD of each thalamic sub-region was quantified. Surgical success was quantified using Engel outcome scores. Results: Significant decreases in thalamic connected volumes to the hippocampus in patients with longer duration of TLE were revealed. Likewise, when stratified based on surgical success, significant differences in diffusion metrics to the hippocampus, parahippocampal gyrus, and temporal neocortex were found. Significant differences did not withstand false discovery rate (FDR) correction. Conclusions: These findings suggest ongoing connectivity changes dependent on epilepsy duration and promote further investigation into the use of thalamic connectivity data as biomarkers for predicting surgical outcomes in TLE patients.

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