scholarly journals LncRNA MEG3 Reduces Hippocampal Neuron Apoptosis via the PI3K/AKT/mTOR Pathway in a Rat Model of Temporal Lobe Epilepsy

2020 ◽  
Vol Volume 16 ◽  
pp. 2519-2528
Author(s):  
Hongyan Zhang ◽  
Jiuyun Tao ◽  
ShuXia Zhang ◽  
XinXin Lv
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
Hippocampal Neuron ◽  
Mtor Pathway ◽  
Neuron Apoptosis

Neuroregenerative Gene Therapy to Treat Temporal Lobe Epilepsy in a Rat Model

2021 ◽  
pp. 102198
Author(s):  
Jiajun Zheng ◽  
Tingjie Li ◽  
Shuang Qi ◽  
Bing Qin ◽  
Jiandong Yu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model

Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy

Epilepsia ◽  
2010 ◽  
Vol 51 (9) ◽  
pp. 1780-1790 ◽  
Author(s):  
Hero Bartmann ◽  
Christina Fuest ◽  
Christian La Fougere ◽  
Guoming Xiong ◽  
Theresa Just ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
Proof Of Concept ◽  
P Glycoprotein

scholarly journals Effect of chemogenetic modulation of hippocampal neurons on depression and spatial memory impairment in a rat model for temporal lobe epilepsy.

2019 ◽  
Vol 13 ◽  
Author(s):  
Erine Craey ◽  
Marie-Gabrielle Goossens ◽  
Jana Desloovere ◽  
Caroline Merckx ◽  
Chris Van Den Haute ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Spatial Memory ◽  
Temporal Lobe ◽  
Rat Model ◽  
Hippocampal Neurons ◽  
Memory Impairment

scholarly journals Modulation of miR-146a/complement factor H-mediated inflammatory responses in a rat model of temporal lobe epilepsy

2016 ◽  
Vol 36 (6) ◽  
Author(s):  
Fang He ◽  
Bei Liu ◽  
Qiang Meng ◽  
Yang Sun ◽  
Weiwen Wang ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
Inflammatory Responses ◽  
Chronic Phase ◽  
Factor H ◽  
Complement Factor H ◽  
Luciferase Reporter ◽  
Complement Factor ◽  
Small Regulatory Rna

Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE). miRNAs represent small regulatory RNA molecules that have been shown to act as negative regulators of gene expression controlling different biological processes, including immune system homoeostasis and function. We investigated the expression and cellular distribution of miRNA-146a (miR-146a) in a rat model of TLE. Prominent up-regulation of miR-146a activation was evident in 1 week after status epilepticus (SE) and persisted in the chronic phase. The predicted miR-146a's target complement factor H (CFH) mRNA and protein expression was also down-regulated in TLE rat model. Furthermore, transfection of miR-146a mimics in neuronal and glial cells down-regulated CFH mRNA and protein levels respectively. Luciferase reporter assays demonstrated that miR-146a down-regulated CFH mRNA expression via 3′-UTR pairing. Down-regulating miR-146a by intracerebroventricular injection of antagomir-146a enhanced the hippocampal expression of CFH in TLE model and decreased seizure susceptibility. These findings suggest that immunopathological deficits associated with TLE can in part be explained by a generalized miR-146a-mediated down-regulation of CFH that may contribute to epileptogenesis in a rat model of TLE.

Hippocampal asymmetry: differences in the left and right hippocampus proteome in the rat model of temporal lobe epilepsy

2017 ◽  
Vol 154 ◽  
pp. 22-29 ◽  
Author(s):  
Leila Sadeghi ◽  
Albert Anatolyevich Rizvanov ◽  
Ilnur Ildusovich Salafutdinov ◽  
Bahareh Dabirmanesh ◽  
Mohammad Sayyah ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
Left And Right
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