scholarly journals P.035 Correlation of thalamic connectivity with the duration of epilepsy in patients with temporal lobe epilepsy

2017 ◽  
Vol 44 (S2) ◽  
pp. S22-S22
Author(s):  
B Santyr ◽  
JC Lau ◽  
SM Mirsattari ◽  
JG Burneo ◽  
S de Ribaupierre ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Parahippocampal Gyrus ◽  
Probabilistic Tractography ◽  
Temporal Lobes ◽  
Surgical Success ◽  
False Discovery ◽  
Long Duration ◽  
Temporal Neocortex

Background: Morphometry and connectivity studies targeting the thalamus have revealed specific patterns of atrophy and deafferentiation in patients with temporal lobe epilepsy (TLE). We used probabilistic tractography to investigate thalamic connectivity with respect to duration of epilepsy and surgical outcomes in TLE. Methods: Patients (N=20) with drug-resistant TLE (10 short duration (<15 years), 10 long duration (>15 years)) were scanned with multi-parametric 3T MRI and compared with 34 healthy controls. The Harvard-Oxford atlas was modified to create 14 target regions in the temporal lobes. Probabilistic tractography (FSL) was used to delineate thalamic sub-regions most connected to each target. The volume, mean T1, T2, FA and MD of each thalamic sub-region was quantified. Surgical success was quantified using Engel outcome scores. Results: Significant decreases in thalamic connected volumes to the hippocampus in patients with longer duration of TLE were revealed. Likewise, when stratified based on surgical success, significant differences in diffusion metrics to the hippocampus, parahippocampal gyrus, and temporal neocortex were found. Significant differences did not withstand false discovery rate (FDR) correction. Conclusions: These findings suggest ongoing connectivity changes dependent on epilepsy duration and promote further investigation into the use of thalamic connectivity data as biomarkers for predicting surgical outcomes in TLE patients.

scholarly journals Long-term surgical outcomes of temporal lobe epilepsy associated with low-grade brain tumors

Cancer ◽  
2009 ◽  
Vol 115 (24) ◽  
pp. 5771-5779 ◽  
Author(s):  
Ji Hoon Phi ◽  
Seung-Ki Kim ◽  
Byung-Kyu Cho ◽  
Seo Young Lee ◽  
Su Yeon Park ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Low Grade

scholarly journals Surgical Outcomes and EEG Prognostic Factors After Stereotactic Laser Amygdalohippocampectomy for Mesial Temporal Lobe Epilepsy

2021 ◽  
Vol 12 ◽  
Author(s):  
Shasha Wu ◽  
Naoum P. Issa ◽  
Maureen Lacy ◽  
David Satzer ◽  
Sandra L. Rose ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Mesial Temporal Lobe Epilepsy ◽  
Seizure Freedom ◽  
Seizure Recurrence ◽  
Factors Associated ◽  
Scalp Eeg ◽  
Mesial Temporal Lobe

Objective: To assess the seizure outcomes of stereotactic laser amygdalohippocampectomy (SLAH) in consecutive patients with mesial temporal lobe epilepsy (mTLE) in a single center and identify scalp EEG and imaging factors in the presurgical evaluation that correlate with post-surgical seizure recurrence.Methods: We retrospectively reviewed the medical and EEG records of 30 patients with drug-resistant mTLE who underwent SLAH and had at least 1 year of follow-up. Surgical outcomes were classified using the Engel scale. Univariate hazard ratios were used to evaluate the risk factors associated with seizure recurrence after SLAH.Results: The overall Engel class I outcome after SLAH was 13/30 (43%), with a mean postoperative follow-up of 48.9 ± 17.6 months. Scalp EEG findings of interictal regional slow activity (IRSA) on the side of surgery (HR = 4.05, p = 0.005) and non-lateralizing or contra-lateralizing seizure onset (HR = 4.31, p = 0.006) were negatively correlated with postsurgical seizure freedom. Scalp EEG with either one of the above features strongly predicted seizure recurrence after surgery (HR = 7.13, p &lt; 0.001) with 100% sensitivity and 71% specificity.Significance: Understanding the factors associated with good or poor surgical outcomes can help choose the best candidates for SLAH. Of the variables assessed, scalp EEG findings were the most clearly associated with seizure outcomes after SLAH.

scholarly journals Intrinsic Thalamic Network in Temporal Lobe Epilepsy With Hippocampal Sclerosis According to Surgical Outcomes

2021 ◽  
Vol 12 ◽  
Author(s):  
Kyoo Ho Cho ◽  
Ho-Joon Lee ◽  
Kyoung Heo ◽  
Sung Eun Kim ◽  
Dong Ah Lee ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Hippocampal Sclerosis ◽  
Three Dimensional ◽  
Thalamic Nuclei ◽  
Characteristic Path Length ◽  
Ipsilateral Hemisphere ◽  
Hippocampal Subfields ◽  
Significant Difference

Background: The aim of this study was to identify the differences of intrinsic amygdala, hippocampal, or thalamic networks according to surgical outcomes in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS).Methods: We enrolled 69 pathologically confirmed TLE patients with HS. All patients had pre-operative three-dimensional T1-weighted MRI using a 3.0 T scanner. We obtained the structural volumes of the amygdala nuclei, hippocampal subfields, and thalamic nuclei. Then, we investigated the intrinsic networks based on volumes of these structures using structural covariance and graph theoretical analysis.Results: Of the 69 TLE patients with HS, 21 patients (42.1%) had poor surgical outcomes, whereas 40 patients (57.9%) had good surgical outcomes. The volumes in the amygdala nuclei, hippocampal subfields, and thalamic nuclei were not different according to surgical outcome. In addition, the intrinsic amygdala and hippocampal networks were not different between the patients with poor and good surgical outcomes. However, there was a significant difference in the intrinsic thalamic network in the ipsilateral hemisphere between them. The eccentricity and small-worldness index were significantly increased, whereas the characteristic path length was decreased in the patients with poor surgical outcomes compared to those with good surgical outcomes.Conclusion: We successfully demonstrated significant differences in the intrinsic thalamic network in the ipsilateral hemisphere between TLE patients with HS with poor and good surgical outcomes. This result suggests that the pre-operative intrinsic thalamic network can be related with surgical outcomes in TLE patients with HS.

scholarly journals Retrograde episodic and semantic memory impairment correlates with side of temporal lobe damage

2008 ◽  
Vol 14 (6) ◽  
pp. 1083-1094 ◽  
Author(s):  
IVANA BUCCIONE ◽  
LUCIA FADDA ◽  
LAURA SERRA ◽  
CARLO CALTAGIRONE ◽  
GIOVANNI A. CARLESIMO
Keyword(s):  
Temporal Lobe ◽  
Memory Impairment ◽  
Hippocampal Formation ◽  
Semantic Knowledge ◽  
Parahippocampal Gyrus ◽  
Herpes Encephalitis ◽  
Temporal Lobes ◽  
First Case ◽  
Retrograde Memory ◽  
The Right

AbstractPatients with damage to the mesial and anterior portions of the temporal lobes suffer from a memory impairment involving both anterograde and retrograde amnesia. In the retrograde domain, it has been suggested that the relative severity of autobiographical and nonautobiographical memory impairment may depend on the prevalent side of the temporal damage. Here we present two patients suffering from damage to the mesial and anterior portions of the temporal lobes (hippocampal formation, parahippocampal gyrus and polar cortex) as a result of herpes encephalitis. In the first case, A.S., damage predominantly affected the right temporal lobe, whereas in the second patient, R.S., the damage was bilateral but more severe on the left side. A detailed investigation of the retrograde memory deficit demonstrated a partial double dissociation between the two patients, with A.S. almost exclusively impaired in the autobiographical domain (both episodic and semantic) and R.S. with poor performances in all domains, but much more severe in the nonautobiographical (both public events and general semantic knowledge) than in the autobiographical one. These findings reinforce the view of specialization of right and left temporal lobes in the retrieval of retrograde autobiographical and nonautobiographical memories, respectively. (JINS, 2008, 14, 1083–1094.)

Letter to the Editor Regarding“Surgical Outcomes of Laser Interstitial Thermal Therapy for Temporal Lobe Epilepsy”

2020 ◽  
Vol 143 ◽  
pp. 626 ◽  
Author(s):  
Ravish R. Keni ◽  
William Andres Florez-Perdomo ◽  
Md Moshiur Rahman ◽  
Luis Rafael Moscote-Salazar ◽  
Amit Agrawal
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy ◽  
Letter To The Editor

Subtemporal transparahippocampal amygdalohippocampectomy for surgical treatment of mesial temporal lobe epilepsy

1996 ◽  
Vol 1 (4) ◽  
pp. E2 ◽  
Author(s):  
T. S. Park ◽  
Blaise F. D. Bourgeois ◽  
Daniel L. Silbergeld ◽  
W. Edwin Dodson
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Pediatric Patients ◽  
Mesial Temporal Lobe Epilepsy ◽  
Fusiform Gyrus ◽  
Parahippocampal Gyrus ◽  
Middle Temporal Gyrus ◽  
Language Mapping ◽  
Mesial Temporal Lobe ◽  
Sodium Amobarbital

Amygdalohippocampectomy (AH) is an accepted surgical option for treatment of medically refractory mesial temporal lobe epilepsy. Operative approaches to the amygdala and hippocampus that previously have been reported include: the sylvian fissure, the superior temporal sulcus, the middle temporal gyrus, and the fusiform gyrus. Regardless of the approach, AH permits not only extirpation of an epileptogenic focus in the amygdala and anterior hippocampus, but interruption of pathways of seizure spread via the entorhinal cortex and the parahippocampal gyrus. The authors report a modification of a surgical technique for AH via the parahippocampal gyrus, in which excision is limited to the anterior hippocampus, amygdala and parahippocampal gyrus while preserving the fusiform gyrus and the rest of the temporal lobe. Because transparahippocampal AH avoids injury to the fusiform gyrus and the lateral temporal lobe, it can be performed without intracarotid sodium amobarbital testing of language dominance and language mapping. Thus the operation would be particularly suitable for pediatric patients in whom intraoperative language mapping before resection is difficult.

The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy

Brain ◽  
1995 ◽  
Vol 118 (1) ◽  
pp. 105-118 ◽  
Author(s):  
Gary W. Mathern ◽  
Thomas L. Babb ◽  
Barbara G. Vickrey ◽  
Maria Melendez ◽  
James K. Pretorius
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Hippocampal Neuron ◽  
Neuron Loss ◽  
Pathogenic Mechanisms

scholarly journals Gambaran penyandang epilepsi berdasarkan ILAE 1989 di Poliklinik Saraf RSUP Prof. Dr. R. D. Kandou Manado tahun 2014

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Patrick G. Tendean ◽  
Winifred . Karema ◽  
Arthur . Mawuntu
Keyword(s):  
Retrospective Study ◽  
Temporal Lobe Epilepsy ◽  
Medical Record ◽  
Temporal Lobe ◽  
Temporal Lobes ◽  
Epileptic Patients ◽  
Using Data

Abstrak: Epilepsy is commonly found in the community. This study aimed to obtain the profile of epileptic patients at Prof Dr. R. D. Kandou Hospital Manado in 2014. This was a descriptive retrospective study using data of Department of Medical Record Prof. Dr. R. D. Kandou Hospital Manado 2014. The results showed that there were 144 subjects that fulfilled the criteria; 81 (56.3%) of them were males. Most of them were at the age 15-24 years, had profession as students, and were diagnosed as temporal lobe epilepsy EEG was performed on 35 subjects; 13 of them had lesion in the temporal lobes. Nearly half of the subjects were treated with phenytoin.Kata kunci: epilepsi, temporal, phenytoin Abstrak: Epilepsi merupakan penyakit yang sering ditemukan di masyarakat. Penelitian ini bertujuan untuk mengetahui gambaran penyandang epilepsi di RSUP Prof. Dr. R. D. Kandou Manado pada tahun 2014. Jenis penelitian ini deskriptif retrospektif dengan memanfaatkan data dari Bagian Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado tahun 2014. Hasil penelitian memperlihatkan sebanyak 144 subjek yang memenuhi kriteria penelitian. Terdapat 81 subjek (56,3%) berjenis kelamin laki-laki. Golongan usia terbanyak ialah 15-24 tahun, sebagian besar berprofesi sebagai pelajar/mahasiswa, dan paling banyak terdiagnosis sebagai epilepsi lobus temporal. EEG dikerjakan pada 35 subjek; sebanyak 13 subjek memiliki letak lesi di lobus temporal. Hampir setengah dari keseluruhan subjek menggunakan terapi phenytoin. Kata kunci: epilepsi, temporal, phenytoin

scholarly journals Seizure Freedom After Epilepsy Surgery and Higher Baseline Cognition May Be Associated With a Negatively Correlated Epilepsy Network in Temporal Lobe Epilepsy

2021 ◽  
Vol 14 ◽  
Author(s):  
Elliot G. Neal ◽  
Mike R. Schoenberg ◽  
Stephanie Maciver ◽  
Yarema B. Bezchlibnyk ◽  
Fernando L. Vale
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Epilepsy Surgery ◽  
Memory Function ◽  
Brain Regions ◽  
Seizure Freedom ◽  
Epileptogenic Zone ◽  
Temporal Lobes ◽  
Scalp Eeg ◽  
The Brain

Background: Brain regions positively correlated with the epileptogenic zone in patients with temporal lobe epilepsy vary in spread across the brain and in the degree of correlation to the temporal lobes, thalamus, and limbic structures, and these parameters have been associated with pre-operative cognitive impairment and seizure freedom after epilepsy surgery, but negatively correlated regions have not been as well studied. We hypothesize that connectivity within a negatively correlated epilepsy network may predict which patients with temporal lobe epilepsy will respond best to surgery.Methods: Scalp EEG and resting state functional MRI (rsfMRI) were collected from 19 patients with temporal lobe epilepsy and used to estimate the irritative zone. Using patients’ rsfMRI, the negatively correlated epilepsy network was mapped by determining all the brain voxels that were negatively correlated with the voxels in the epileptogenic zone and the spread and average connectivity within the network was determined.Results: Pre-operatively, connectivity within the negatively correlated network was inversely related to the spread (diffuseness) of that network and positively associated with higher baseline verbal and logical memory. Pre-operative connectivity within the negatively correlated network was also significantly higher in patients who would go on to be seizure free.Conclusion: Patients with higher connectivity within brain regions negatively correlated with the epilepsy network had higher baseline memory function, narrower network spread, and were more likely to be seizure free after surgery.

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