scholarly journals Temporal lobe epilepsy patients with severe hippocampal neuron loss but normal hippocampal volume: Extracellular matrix molecules are important for the maintenance of hippocampal volume

Epilepsia ◽  
2015 ◽  
Vol 56 (10) ◽  
pp. 1562-1570 ◽  
Author(s):  
Jose Eduardo Peixoto-Santos ◽  
Tonicarlo Rodrigues Velasco ◽  
Orfa Yineth Galvis-Alonso ◽  
David Araujo ◽  
Ludmyla Kandratavicius ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Neuron ◽  
Hippocampal Volume ◽  
Neuron Loss ◽  
Extracellular Matrix Molecules

The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy

Brain ◽  
1995 ◽  
Vol 118 (1) ◽  
pp. 105-118 ◽  
Author(s):  
Gary W. Mathern ◽  
Thomas L. Babb ◽  
Barbara G. Vickrey ◽  
Maria Melendez ◽  
James K. Pretorius
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Surgical Outcomes ◽  
Hippocampal Neuron ◽  
Neuron Loss ◽  
Pathogenic Mechanisms

scholarly journals Histological correlates of hippocampal magnetization transfer images in drug-resistant temporal lobe epilepsy patients

2020 ◽  
Author(s):  
Jose Eduardo Peixoto-Santos ◽  
Tonicarlo Rodrigues Velasco ◽  
Carlos Gilberto Carlotti ◽  
Joao Alberto Assirati ◽  
Gustavo Henrique de Souza e Rezende ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Temporal Lobe Epilepsy ◽  
Chondroitin Sulfate ◽  
Temporal Lobe ◽  
Magnetization Transfer ◽  
Reactive Astrocytes ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Neuron Density ◽  
Extracellular Matrix Molecules

Temporal lobe epilepsy patients (TLE) often present with hippocampal atrophy, increased T2 relaxation, and reduced magnetization transfer ratio (MTR) in magnetic resonance images (MRI). The histological correlates of the reduced MTR are so far unknown. Since MTR is dependent on the tissue macromolecules, our aim was to evaluate the correlations between cellular populations, extracellular matrix molecules and the MTR in TLE patients. Patients with TLE (n=27) and voluntaries (=20) were scanned in a 3 Tesla MRI scanner, and MTR images were calculated from 3DT1 sequences with magnetization pulse on resonance. Immunohistochemistry for neurons, reactive astrocytes, activated microglia, and extracellular matrix chondroitin sulfate were performed in formalin fixed, paraffin embedded tissues of TLE and autopsy controls (n=10). Results were considered significant at p<0.05. Compared to the respective controls, TLE patients had reduced hippocampal MTR, increased reactive astrocytes and activated microglia, increased extracellular chondroitin sulfate, and reduced neuron density, compares to controls. MTR correlated positively with neuron density in CA3 and with chondroitin sulfate in CA3 and CA1. Multiple linear regressions reinforced the correlations between chondroitin sulfate and MTR. Our data indicate that extracellular matrix molecules are the most significant histological correlates of magnetization transfer ratio in the hippocampus of TLE patients.

Status Epilepticus-Induced Neurogenesis and Neuron Loss in the Kainate Model of Temporal Lobe Epilepsy

2003 ◽  
Vol 21 (2) ◽  
pp. 157-166
Author(s):  
Takashi Ninomiya ◽  
Kiyoshi Morimoto ◽  
Takemi Watanabe ◽  
Tohru Hirao ◽  
Osamu Yasuhara ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Neuron Loss

scholarly journals Manual Hippocampal Subfield Segmentation Using High-Field MRI: Impact of Different Subfields in Hippocampal Volume Loss of Temporal Lobe Epilepsy Patients

2018 ◽  
Vol 9 ◽  
Author(s):  
Jose Eduardo Peixoto-Santos ◽  
Luciana Estefani Drumond de Carvalho ◽  
Ludmyla Kandratavicius ◽  
Paula Rejane Beserra Diniz ◽  
Renata Caldo Scandiuzzi ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Field ◽  
Hippocampal Volume ◽  
Volume Loss ◽  
High Field Mri

Reduced glutamine synthetase in hippocampal areas with neuron loss in temporal lobe epilepsy

Neurology ◽  
2005 ◽  
Vol 64 (2) ◽  
pp. 326-333 ◽  
Author(s):  
W. S. van der Hel ◽  
R. G.E. Notenboom ◽  
I. W.M. Bos ◽  
P. C. van Rijen ◽  
C. W.M. van Veelen ◽  
...  
Keyword(s):  
Glutamine Synthetase ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Neuron Loss
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