Metabolic Syndrome, Cardiovascular Disease, and Risk for Chronic Kidney Disease in an Italian Cohort: Analysis of the INCIPE Study

2011 ◽  
Vol 9 (5) ◽  
pp. 381-388 ◽  
Author(s):  
Pietro Manuel Ferraro ◽  
Antonio Lupo ◽  
Tewoldemedhn Yabarek ◽  
Maria Stella Graziani ◽  
Luciana Bonfante ◽  
...  
2019 ◽  
Vol 25 (6) ◽  
pp. 700-709 ◽  
Author(s):  
Shuangshuang Zhang ◽  
Yong Wang ◽  
Jinsong Cheng ◽  
Ning Huangfu ◽  
Ruochi Zhao ◽  
...  

Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan.


2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Mário Raimundo ◽  
José António Lopes

The metabolic syndrome (MS) and chronic kidney disease (CKD) have both become global public health problems, with increasing social and economic impact due to their high prevalence and remarkable impact on morbidity and mortality. The causality between MS and CKD, and its clinical implications, still does remain not completely understood. Moreover, prophylactic and therapeutic interventions do need to be properly investigated in this field. Herein, we critically review the existing clinical evidence that associates MS with renal disease and cardiovascular disease, as well as the associated pathophysiologic mechanisms and actual treatment options.


2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Kosaku Nitta

Metabolic syndrome (MetS) is a clinical syndrome that consists of visceral obesity, dyslipidemia, hypertension, and impaired insulin sensitivity. Although individual components of MetS have been implicated in the development of chronic kidney disease (CKD), few studies have examined the effect of combinations of the components of MetS on the development of CKD and cardiovascular disease (CVD). The prevalence of MetS is increasing worldwide in both developing and developed countries, and early detection and treatment of MetS would be a cost-effective strategy for preventing the development of CKD. Visceral obesity and insulin resistance are two important features of MetS that may be associated with renal damage. Lifestyle modifications, including caloric restriction and exercise, are necessary to treat MetS. Initial antihypertensive therapy should consist of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker. An improved understanding of the mechanism responsible for the association between MetS and renal damage should be helpful in determining the treatment regimens directed at cardiovascular and renal protection.


2021 ◽  
pp. 181-190
Author(s):  
Deepti Avasthi ◽  
Edara Dharmakaruna ◽  
Salil Avasthi

Magnesium participates in more than 600 enzymatic reactions in the body. Its role in the treatment of cardiac arrhythmias and pre-eclampsia is already well established. Magnesium`s role in preventive medicine is not very well described in medicine literature. We have carefully studied the pathophysiology of magnesium and explained its role in hypertension, chronic kidney disease, vascular calcication, metabolic syndrome and mortality from cardiovascular disease. Through this article we hope to add to the existing knowledge of magnesium metabolism, its role in cardiovascular pathology and potential benets of magnesium supplements on health.


2017 ◽  
Vol 39 (3) ◽  
Author(s):  
Suzana Greffin ◽  
Mauro Barros André ◽  
Jorge Paulo Strogoff de Matos ◽  
Hye Chung Kang ◽  
Antonio José Lagoeiro Jorge ◽  
...  

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