scholarly journals Effects of Hydrogen Sulfide-Releasing Compounds on Aqueous Humor Outflow Facility in Porcine Ocular Anterior Segments, Ex Vivo

2017 ◽  
Vol 33 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Jenaye Robinson ◽  
Esther Okoro ◽  
Chinoso Ezuedu ◽  
Leah Bush ◽  
Catherine A. Opere ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Aqueous Humor ◽  
Ex Vivo ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Anterior Segments

5-Methylurapidil, 8-Iso Prostaglandin E2: New Drugs to Increase Aqueous-Humor Outflow Facility

2000 ◽  
pp. 253-259
Author(s):  
J. B. Serle ◽  
S. M. Podos ◽  
R.-F. Wang ◽  
T. Mittag ◽  
P.-Y. Lee ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Aqueous Humor ◽  
New Drugs ◽  
Outflow Facility ◽  
Aqueous Humor Outflow

Role of Lysophospholipid Growth Factors in the Modulation of Aqueous Humor Outflow Facility

2004 ◽  
Vol 45 (7) ◽  
pp. 2263 ◽  
Author(s):  
Priyatham Sai Mettu ◽  
Pei-Feng Deng ◽  
Uma K. Misra ◽  
Govind Gawdi ◽  
David L. Epstein ◽  
...  
Keyword(s):  
Growth Factors ◽  
Aqueous Humor ◽  
Outflow Facility ◽  
Aqueous Humor Outflow

The role of protein kinase C in modulation of aqueous humor outflow facility

2003 ◽  
Vol 76 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Rahul N Khurana ◽  
Pei-Feng Deng ◽  
David L Epstein ◽  
P Vasantha Rao
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Aqueous Humor ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Kinase C

scholarly journals Vascular Endothelial Growth Factor-A Increases the Aqueous Humor Outflow Facility

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0161332 ◽  
Author(s):  
Tomokazu Fujimoto ◽  
Toshihiro Inoue ◽  
Kei Maki ◽  
Miyuki Inoue-Mochita ◽  
Hidenobu Tanihara
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Aqueous Humor ◽  
Vascular Endothelial ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Endothelial Growth Factor

scholarly journals Effects of Y27632 on Aqueous Humor Outflow Facility With Changes in Hydrodynamic Pattern and Morphology in Human Eyes

2013 ◽  
Vol 54 (8) ◽  
pp. 5859 ◽  
Author(s):  
Chen-Yuan Charlie Yang ◽  
Ye Liu ◽  
Zhaozeng Lu ◽  
Ruiyi Ren ◽  
Haiyan Gong
Keyword(s):  
Aqueous Humor ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Human Eyes

scholarly journals Intraocular Pressure Reduction in a Pigmentary Glaucoma Model by Goniotome Ab Interno Trabeculectomy

2018 ◽  
Author(s):  
Chao Wang ◽  
Yalong Dang ◽  
Priyal Shah ◽  
Hamed Esfandiari ◽  
Ying Hong ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ex Vivo ◽  
Pigmentary Glaucoma ◽  
Pressure Reduction ◽  
Outflow Facility ◽  
Intraocular Pressure Reduction ◽  
Ab Interno Trabeculectomy ◽  
Hematoxylin And Eosin ◽  
Anterior Segments ◽  
Ab Interno

Purpose: To investigate whether microsurgical excision of trabecular meshwork (TM) in an ex vivo pigmentary glaucoma model can normalize the hypertensive phenotype. Methods: Eight eyes of a porcine pigmentary glaucoma model underwent 90° of microsurgical TM excision with an aspirating dual-blade (Goniotome (G)). 24 hours later, an additional 90° of TM were removed. Anterior segments with sham surgeries served as the control (C). Outflow facility and intraocular pressure (IOP) were analyzed. Histology with hematoxylin and eosin (H&E) was obtained. Results: After the first 90° TM excision, IOP was significantly lower in G (10.23±2.39 mmHg, n=7) than C (20.04±1.97mmHg, n=8, P<0.01). Outflow facility in G (0.38±0.07 µl/min/mmHg) was higher than C (0.16±0.02 µl/min/mmHg, P<0.01). After the second 90° TM excision, IOP in G (6.46±0.81 mmHg, n=7) was significantly lower than C (20.25±1.66 mmHg, n=8, P<0.001), while the outflow facility in G (0.50±0.05 µl/min/mmHg, n=7) was higher than C (0.16±0.01 µl/min/mmHg, n=8, P<0.001). Compared to the first excision, excision of an additional 90° did not change of IOP (P=0.20) or outflow facility (P=0.17) further. Conclusion: Excision of 90° of TM in a pigmentary glaucoma model using an aspirating dual-blade decreased IOP and increased outflow facility. Translational Relevance: Microsurgical TM excision over 90° can effectively restore outflow in pigmentary glaucoma.

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