scholarly journals Effects of Y27632 on Aqueous Humor Outflow Facility With Changes in Hydrodynamic Pattern and Morphology in Human Eyes

2013 ◽  
Vol 54 (8) ◽  
pp. 5859 ◽  
Author(s):  
Chen-Yuan Charlie Yang ◽  
Ye Liu ◽  
Zhaozeng Lu ◽  
Ruiyi Ren ◽  
Haiyan Gong
Keyword(s):  
Aqueous Humor ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Human Eyes

scholarly journals Effect of Timolol on Aqueous Humor Outflow Facility in Healthy Human Eyes

2019 ◽  
Vol 202 ◽  
pp. 126-132 ◽  
Author(s):  
Arash Kazemi ◽  
Jay W. McLaren ◽  
Matthew G.J. Trese ◽  
Carol B. Toris ◽  
Vikas Gulati ◽  
...  
Keyword(s):  
Aqueous Humor ◽  
Healthy Human ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Human Eyes

5-Methylurapidil, 8-Iso Prostaglandin E2: New Drugs to Increase Aqueous-Humor Outflow Facility

2000 ◽  
pp. 253-259
Author(s):  
J. B. Serle ◽  
S. M. Podos ◽  
R.-F. Wang ◽  
T. Mittag ◽  
P.-Y. Lee ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Aqueous Humor ◽  
New Drugs ◽  
Outflow Facility ◽  
Aqueous Humor Outflow

Role of Lysophospholipid Growth Factors in the Modulation of Aqueous Humor Outflow Facility

2004 ◽  
Vol 45 (7) ◽  
pp. 2263 ◽  
Author(s):  
Priyatham Sai Mettu ◽  
Pei-Feng Deng ◽  
Uma K. Misra ◽  
Govind Gawdi ◽  
David L. Epstein ◽  
...  
Keyword(s):  
Growth Factors ◽  
Aqueous Humor ◽  
Outflow Facility ◽  
Aqueous Humor Outflow

The role of protein kinase C in modulation of aqueous humor outflow facility

2003 ◽  
Vol 76 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Rahul N Khurana ◽  
Pei-Feng Deng ◽  
David L Epstein ◽  
P Vasantha Rao
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Aqueous Humor ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Kinase C

scholarly journals Vascular Endothelial Growth Factor-A Increases the Aqueous Humor Outflow Facility

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0161332 ◽  
Author(s):  
Tomokazu Fujimoto ◽  
Toshihiro Inoue ◽  
Kei Maki ◽  
Miyuki Inoue-Mochita ◽  
Hidenobu Tanihara
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Aqueous Humor ◽  
Vascular Endothelial ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Endothelial Growth Factor

scholarly journals S1P2 receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology

2011 ◽  
Vol 300 (5) ◽  
pp. C1164-C1171 ◽  
Author(s):  
Grant M. Sumida ◽  
W. Daniel Stamer
Keyword(s):  
Intraocular Pressure ◽  
Open Angle Glaucoma ◽  
Primary Cultures ◽  
Receptor Activation ◽  
Outflow Resistance ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Sphingosine 1 Phosphate ◽  
Mlc Phosphorylation ◽  
Human Eyes

Elevated intraocular pressure is the main risk factor in primary open-angle glaucoma, involving an increased resistance to aqueous humor outflow in the juxtacanalicular region of the conventional outflow pathway which includes the trabecular meshwork (TM) and the inner wall of Schlemm's canal (SC). Previously, sphingosine-1-phosphate (S1P) was shown to decrease outflow facility in porcine and human eyes, thus increasing outflow resistance and intraocular pressure. Owing to S1P's known effect of increasing barrier function in endothelial cells and the robust expression of the S1P1 receptor on the inner wall of SC, we hypothesized that S1P1 receptor activation promotes junction formation and decreases outflow facility. The effects of subtype-specific S1P receptor compounds were tested in human and porcine whole-eye perfusions and human primary cultures of SC and TM cells to determine the receptor responsible for S1P effects on outflow resistance. The S1P1-specific agonist SEW2871 failed to both mimic S1P effects in paired human eye perfusions, as well as increase myosin light chain (MLC) phosphorylation in cell culture, a prominent outcome in S1P-treated SC and TM cells. In contrast, the S1P2 antagonist JTE-013, but not the S1P1 or S1P1,3 antagonists, blocked the S1P-promoted increase in MLC phosphorylation. Moreover, JTE-013 prevented S1P-induced decrease in outflow facility in perfused human eyes ( P < 0.05, n = 6 pairs). Similarly, porcine eyes perfused with JTE-013 + S1P did not differ from eyes with JTE-013 alone ( P = 0.53, n = 3). These results demonstrate that S1P2, and not S1P1 or S1P3, receptor activation increases conventional outflow resistance and is a potential target to regulate intraocular pressure.

scholarly journals Effects of Hydrogen Sulfide-Releasing Compounds on Aqueous Humor Outflow Facility in Porcine Ocular Anterior Segments, Ex Vivo

2017 ◽  
Vol 33 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Jenaye Robinson ◽  
Esther Okoro ◽  
Chinoso Ezuedu ◽  
Leah Bush ◽  
Catherine A. Opere ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Aqueous Humor ◽  
Ex Vivo ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Anterior Segments
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