Aqueous humor outflow effects of partial thickness channel created by a femtosecond laser in ex-vivo human eyes

2007 ◽  
Author(s):  
Dongyul Chai ◽  
Gautam Chaudhary ◽  
Ron Kurtz ◽  
Tibor Juhasz
Keyword(s):  
Femtosecond Laser ◽  
Aqueous Humor ◽  
Ex Vivo ◽  
Aqueous Humor Outflow ◽  
Partial Thickness ◽  
Human Eyes

scholarly journals Effects of Y27632 on Aqueous Humor Outflow Facility With Changes in Hydrodynamic Pattern and Morphology in Human Eyes

2013 ◽  
Vol 54 (8) ◽  
pp. 5859 ◽  
Author(s):  
Chen-Yuan Charlie Yang ◽  
Ye Liu ◽  
Zhaozeng Lu ◽  
Ruiyi Ren ◽  
Haiyan Gong
Keyword(s):  
Aqueous Humor ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Human Eyes

scholarly journals Effects of Hydrogen Sulfide-Releasing Compounds on Aqueous Humor Outflow Facility in Porcine Ocular Anterior Segments, Ex Vivo

2017 ◽  
Vol 33 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Jenaye Robinson ◽  
Esther Okoro ◽  
Chinoso Ezuedu ◽  
Leah Bush ◽  
Catherine A. Opere ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Aqueous Humor ◽  
Ex Vivo ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Anterior Segments

scholarly journals Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT)

2011 ◽  
Vol 92 (2) ◽  
pp. 104-111 ◽  
Author(s):  
Cheryl R. Hann ◽  
Michael D. Bentley ◽  
Andrew Vercnocke ◽  
Erik L. Ritman ◽  
Michael P. Fautsch
Keyword(s):  
Computed Tomography ◽  
Aqueous Humor ◽  
Three Dimensional ◽  
Micro Ct ◽  
Micro Computed Tomography ◽  
Aqueous Humor Outflow ◽  
Human Eyes ◽  
Outflow Pathway

Development of a Two-Color Fluorescent Tracer Technique to Study Aqueous Outflow Patterns and Outflow Resistance in Human Eyes

2007 ◽  
Author(s):  
Steven J. Folz ◽  
Hiayan Gong ◽  
Darryl R. Overby
Keyword(s):  
Intraocular Pressure ◽  
Aqueous Humor ◽  
Tracer Technique ◽  
Outflow Resistance ◽  
Fluorescent Tracer ◽  
Aqueous Humor Outflow ◽  
Elevated Intraocular Pressure ◽  
Human Eyes ◽  
Outflow Pathway ◽  
Aqueous Outflow

Glaucoma is a leading cause of blindness, and elevated intraocular pressure (IOP) characteristic of glaucoma is caused by increased aqueous humor outflow resistance. Studies have localized the bulk of outflow resistance to particular regions along the outflow pathway — namely, the inner wall endothelium of Schlemm’s canal and its underlying juxtacanalicular tissue (JCT) [1] — but the hydrodynamic details of how aqueous humor flows through these tissues and how these tissues generate outflow resistance are not well understood.

scholarly journals A Chronic Ocular-Hypertensive Rat Model induced by Injection of the Sclerosant Agent Polidocanol in the Aqueous Humor Outflow Pathway

2019 ◽  
Vol 20 (13) ◽  
pp. 3209 ◽  
Author(s):  
Román Blanco ◽  
Gema Martinez-Navarrete ◽  
Consuelo Pérez-Rico ◽  
Francisco J. Valiente-Soriano ◽  
Marcelino Avilés-Trigueros ◽  
...  
Keyword(s):  
Aqueous Humor ◽  
Rat Model ◽  
Ganglion Cells ◽  
Ex Vivo ◽  
Cell Loss ◽  
Fiber Layer ◽  
Full Field ◽  
Aqueous Humor Outflow ◽  
Outflow Pathway

Background: To induce a moderate chronic ocular hypertension (OHT) by injecting polidocanol, a foamed sclerosant drug, in the aqueous humor outflow pathway. Methods: Intraocular pressure (IOP) was monitored for up to 6 months. Pattern and full-field electroretinogram (PERG and ERG) were recorded and retinal ganglion cells (RGC) and retinal nerve fiber layer (RNFL) thickness were assessed in vivo with optical coherence tomography (OCT) and ex vivo using Brn3a immunohistochemistry. Results: In the first 3 weeks post-injection, a significant IOP elevation was observed in the treated eyes (18.47 ± 3.36 mmHg) when compared with the control fellow eyes (12.52 ± 2.84 mmHg) (p < 0.05). At 8 weeks, 65% (11/17) of intervention eyes had developed an IOP increase >25% over the baseline. PERG responses were seen to be significantly reduced in the hypertensive eyes (2.25 ± 0.24 µV) compared to control eyes (1.44 ± 0.19 µV) (p < 0.01) at week 3, whereas the ERG components (photoreceptor a-wave and bipolar cell b-wave) remained unaltered. By week 24, RNFL thinning and cell loss in the ganglion cell layer was first detected (2/13, 15.3%) as assessed by OCT and light microscopy. Conclusions: This novel OHT rat model, with moderate levels of chronically elevated IOP, and abnormal PERG shows selective functional impairment of RGC.

scholarly journals Effect of Timolol on Aqueous Humor Outflow Facility in Healthy Human Eyes

2019 ◽  
Vol 202 ◽  
pp. 126-132 ◽  
Author(s):  
Arash Kazemi ◽  
Jay W. McLaren ◽  
Matthew G.J. Trese ◽  
Carol B. Toris ◽  
Vikas Gulati ◽  
...  
Keyword(s):  
Aqueous Humor ◽  
Healthy Human ◽  
Outflow Facility ◽  
Aqueous Humor Outflow ◽  
Human Eyes

Obstruction of Aqueous Humor Outflow by Cross-linked Polyacrylamide Microgels in Bovine, Monkey, and Human Eyes

Ophthalmology ◽  
1994 ◽  
Vol 101 (10) ◽  
pp. 1672-1679 ◽  
Author(s):  
Paul L. Kaufman ◽  
Elke Lütjen-Drecoll ◽  
William C. Hubbard ◽  
Kristine A. Erickson
Keyword(s):  
Aqueous Humor ◽  
Aqueous Humor Outflow ◽  
Human Eyes

scholarly journals Ex-Vivo Measurement of the pH in Aqueous Humor Samples by a Tapered Fiber-Optic Sensor

Sensors ◽  
2021 ◽  
Vol 21 (15) ◽  
pp. 5075
Author(s):  
Ondřej Podrazký ◽  
Jan Mrázek ◽  
Jana Proboštová ◽  
Soňa Vytykáčová ◽  
Ivan Kašík ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Aqueous Humor ◽  
Fiber Optic ◽  
Ex Vivo ◽  
Sol Gel ◽  
Ph Sensor ◽  
Fiber Optic Sensor ◽  
Optic Sensor ◽  
Tapered Optical Fiber ◽  
Practical Demonstration

A practical demonstration of pH measurement in real biological samples with an in-house developed fiber-optic pH sensor system is presented. The sensor uses 8-hydroxypyrene-1,3,6-trisulfonate (HPTS) fluorescent dye as the opto-chemical transducer. The dye is immobilized in a hybrid sol-gel matrix at the tip of a tapered optical fiber. We used 405 nm and 450 nm laser diodes for the dye excitation and a photomultiplier tube as a detector. The sensor was used for the measurement of pH in human aqueous humor samples during cataract surgery. Two groups of patients were tested, one underwent conventional phacoemulsification removal of the lens while the other was subjected to femtosecond laser assisted cataract surgery (FLACS). The precision of the measurement was ±0.04 pH units. The average pH of the aqueous humor of patients subjected to FLACS and those subjected to phacoemulsification were 7.24 ± 0.17 and 7.31 ± 0.20 respectively.

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