scholarly journals Short Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa

2021 ◽  
Vol 37 (1) ◽  
pp. 57-61
Author(s):  
Djeneba Dabitao ◽  
Mamadou Dembele ◽  
Michael Urbanowski ◽  
Bourahima Kone ◽  
Mamadou Wague ◽  
...  
2014 ◽  
Vol 30 (8) ◽  
pp. 806-811 ◽  
Author(s):  
Laith Q. Al-Mawsawi ◽  
Nicholas C. Wu ◽  
Justin De La Cruz ◽  
Vivian Cai Shi ◽  
Ting-Ting Wu ◽  
...  

2015 ◽  
Vol 31 (11) ◽  
pp. 1160-1165 ◽  
Author(s):  
Marina R. Alexander ◽  
Rogier W. Sanders ◽  
John P. Moore ◽  
Per Johan Klasse

1995 ◽  
Vol 2 (3) ◽  
pp. 174-177 ◽  
Author(s):  
Thomas R. Eng ◽  
Thomas R. O'Brien ◽  
Kenneth W. Bernard ◽  
Charles A. Schable ◽  
Theresa van der Vlugt ◽  
...  
Keyword(s):  

2001 ◽  
Vol 98 (9) ◽  
pp. 5199-5204 ◽  
Author(s):  
E. Gonzalez ◽  
R. Dhanda ◽  
M. Bamshad ◽  
S. Mummidi ◽  
R. Geevarghese ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-28 ◽  
Author(s):  
Luna Li ◽  
Satinder Dahiya ◽  
Sandhya Kortagere ◽  
Benjamas Aiamkitsumrit ◽  
David Cunningham ◽  
...  

The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional domains of Tat and its interaction with transactivation response element RNA and cellular transcription factors have been examined. Genetic variation withintatof different HIV-1 subtypes has been shown to affect the interaction of the viral transactivator with cellular and/or viral proteins, influencing the overall level of transcriptional activation as well as its action as a neurotoxic protein. Consequently, the genetic variability withintatmay impact the molecular architecture of functional domains of the Tat protein that may impact HIV pathogenesis and disease. Tat as a therapeutic target for anti-HIV drugs has also been discussed.


2009 ◽  
Vol 92 (9) ◽  
pp. 4683-4688 ◽  
Author(s):  
P. Løvendahl ◽  
M.G.G. Chagunda

Sign in / Sign up

Export Citation Format

Share Document