scholarly journals Short Communication: HIV-1 Gag Genetic Variation in a Single Acutely Infected Participant Defined by High-Resolution Deep Sequencing

2014 ◽  
Vol 30 (8) ◽  
pp. 806-811 ◽  
Author(s):  
Laith Q. Al-Mawsawi ◽  
Nicholas C. Wu ◽  
Justin De La Cruz ◽  
Vivian Cai Shi ◽  
Ting-Ting Wu ◽  
...  
Keyword(s):  
Genetic Variation ◽  
High Resolution ◽  
Deep Sequencing ◽  
Short Communication ◽  
Hiv 1 ◽  
Infected Participant

scholarly journals Short Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa

2021 ◽  
Vol 37 (1) ◽  
pp. 57-61
Author(s):  
Djeneba Dabitao ◽  
Mamadou Dembele ◽  
Michael Urbanowski ◽  
Bourahima Kone ◽  
Mamadou Wague ◽  
...  
Keyword(s):  
Genetic Variation ◽  
West Africa ◽  
Short Communication ◽  
Proximal Promoter ◽  
Hiv 1 ◽  
Human Il10

scholarly journals Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein

2015 ◽  
Vol 31 (11) ◽  
pp. 1160-1165 ◽  
Author(s):  
Marina R. Alexander ◽  
Rogier W. Sanders ◽  
John P. Moore ◽  
Per Johan Klasse
Keyword(s):  
Envelope Glycoprotein ◽  
Short Communication ◽  
Hiv 1

scholarly journals Combination of Immune and Viral Factors Distinguishes Low-Risk versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects

2012 ◽  
Vol 86 (18) ◽  
pp. 9802-9816 ◽  
Author(s):  
Melissa M. Norström ◽  
Marcus Buggert ◽  
Johanna Tauriainen ◽  
Wendy Hartogensis ◽  
Mattia C. Prosperi ◽  
...  
Keyword(s):  
T Cell ◽  
High Risk ◽  
High Resolution ◽  
Disease Progression ◽  
T Cell Responses ◽  
Low Risk ◽  
Early Infection ◽  
Cell Responses ◽  
Cell Counts ◽  
Hiv 1

HLA-B*5701 is the host factor most strongly associated with slow HIV-1 disease progression, although rates can vary within this group. Underlying mechanisms are not fully understood but likely involve both immunological and virological dynamics. The present study investigated HIV-1in vivoevolution and epitope-specific CD8+T cell responses in six HLA-B*5701 patients who had not received antiretroviral treatment, monitored from early infection for up to 7 years. The subjects were classified as high-risk progressors (HRPs) or low-risk progressors (LRPs) based on baseline CD4+T cell counts. Dynamics of HIV-1 Gag p24 evolution and multifunctional CD8+T cell responses were evaluated by high-resolution phylogenetic analysis and polychromatic flow cytometry, respectively. In all subjects, substitutions occurred more frequently in flanking regions than in HLA-B*5701-restricted epitopes. In LRPs, p24 sequence diversity was significantly lower; sequences exhibited a higher degree of homoplasy and more constrained mutational patterns than HRPs. The HIV-1 intrahost evolutionary rate was also lower in LRPs and followed a strict molecular clock, suggesting neutral genetic drift rather than positive selection. Additionally, polyfunctional CD8+T cell responses, particularly to TW10 and QW9 epitopes, were more robust in LRPs, who also showed significantly higher interleukin-2 (IL-2) production in early infection. Overall, the findings indicate that HLA-B*5701 patients with higher CD4 counts at baseline have a lower risk of HIV-1 disease progression because of the interplay between specific HLA-linked immune responses and the rate and mode of viral evolution. The study highlights the power of a multidisciplinary approach, integrating high-resolution evolutionary and immunological data, to understand mechanisms underlying HIV-1 pathogenesis.

scholarly journals Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G

2017 ◽  
Vol 3 (2) ◽  
pp. 220-233 ◽  
Author(s):  
Darja Pollpeter ◽  
Maddy Parsons ◽  
Andrew E. Sobala ◽  
Sashika Coxhead ◽  
Rupert D. Lang ◽  
...  
Keyword(s):  
Deep Sequencing ◽  
Hiv 1
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