scholarly journals Short Communication: Inhibition of DC-SIGN-Mediated HIV-1 Infection by Complementary Actions of Dendritic Cell Receptor Antagonists and Env-Targeting Virus Inactivators

2016 ◽  
Vol 32 (1) ◽  
pp. 93-100 ◽  
Author(s):  
Sergey Pustylnikov ◽  
Rajnish S. Dave ◽  
Zafar K. Khan ◽  
Vanessa Porkolab ◽  
Adel A. Rashad ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Short Communication ◽  
Cell Receptor ◽  
Receptor Antagonists ◽  
Complementary Actions ◽  
Hiv 1

scholarly journals Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

PLoS Biology ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. e1001448 ◽  
Author(s):  
Nuria Izquierdo-Useros ◽  
Maier Lorizate ◽  
Maria C. Puertas ◽  
Maria T. Rodriguez-Plata ◽  
Nadine Zangger ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Receptor ◽  
Viral Membrane ◽  
Trans Infection ◽  
Hiv 1

scholarly journals HIV-1 Envelope Conformation, Allostery, and Dynamics

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 852
Author(s):  
Ashley Lauren Bennett ◽  
Rory Henderson
Keyword(s):  
Host Cell ◽  
Conformational Changes ◽  
Neutralizing Antibodies ◽  
Critical Role ◽  
Cell Receptor ◽  
Broadly Neutralizing Antibodies ◽  
Structural Mapping ◽  
Host Cell Receptor ◽  
Immunogen Design ◽  
Hiv 1

The HIV-1 envelope glycoprotein (Env) mediates host cell fusion and is the primary target for HIV-1 vaccine design. The Env undergoes a series of functionally important conformational rearrangements upon engagement of its host cell receptor, CD4. As the sole target for broadly neutralizing antibodies, our understanding of these transitions plays a critical role in vaccine immunogen design. Here, we review available experimental data interrogating the HIV-1 Env conformation and detail computational efforts aimed at delineating the series of conformational changes connecting these rearrangements. These studies have provided a structural mapping of prefusion closed, open, and transition intermediate structures, the allosteric elements controlling rearrangements, and state-to-state transition dynamics. The combination of these investigations and innovations in molecular modeling set the stage for advanced studies examining rearrangements at greater spatial and temporal resolution.

scholarly journals Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection

2015 ◽  
Vol 9 (1) ◽  
pp. 24-37 ◽  
Author(s):  
S M Dillon ◽  
E J Lee ◽  
C V Kotter ◽  
G L Austin ◽  
S Gianella ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Dendritic Cell Activation ◽  
Hiv 1

scholarly journals Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein

2015 ◽  
Vol 31 (11) ◽  
pp. 1160-1165 ◽  
Author(s):  
Marina R. Alexander ◽  
Rogier W. Sanders ◽  
John P. Moore ◽  
Per Johan Klasse
Keyword(s):  
Envelope Glycoprotein ◽  
Short Communication ◽  
Hiv 1

T cell receptor γδ repertoire in HIV-1-infected individuals

1994 ◽  
Vol 24 (12) ◽  
pp. 3044-3049 ◽  
Author(s):  
Thomas Hinz ◽  
Daniela Wesch ◽  
Klaus Friese ◽  
Anne Reckziegel ◽  
Bernhard Arden ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Hiv 1

scholarly journals Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

2008 ◽  
Vol 14 (12) ◽  
pp. 1390-1395 ◽  
Author(s):  
Angel Varela-Rohena ◽  
Peter E Molloy ◽  
Steven M Dunn ◽  
Yi Li ◽  
Megan M Suhoski ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Immune Escape ◽  
Cell Receptor ◽  
Hiv 1

HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling

1995 ◽  
Vol 25 (5) ◽  
pp. 1417-1425 ◽  
Author(s):  
Pascale Hubert ◽  
Georges Bismuth ◽  
Marie Körner ◽  
Patrice Debré
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Interactions ◽  
Glycoprotein Gp120 ◽  
Hiv 1
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