Evaluation of the (−)‐Ephedrine Imprinted Polymers with High Affinity for Template Molecule Synthesized Using Redox Initiation System

2005 ◽  
Vol 38 (2) ◽  
pp. 227-236 ◽  
Author(s):  
Shuxia Liu ◽  
Xiangchao Dong ◽  
Fangxing Li
Keyword(s):  
Template Molecule ◽  
Imprinted Polymers ◽  
High Affinity ◽  
Redox Initiation ◽  
Initiation System

scholarly journals Molecular Recognition: Perspective and a New Approach

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2757
Author(s):  
W. Rudolf Seitz ◽  
Casey J. Grenier ◽  
John R. Csoros ◽  
Rongfang Yang ◽  
Tianyu Ren
Keyword(s):  
Molecular Recognition ◽  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Binding Kinetics ◽  
Molecularly Imprinted ◽  
New Approach ◽  
Imprinted Polymers ◽  
High Affinity ◽  
Water Blocking ◽  
High Level

This perspective presents an overview of approaches to the preparation of molecular recognition agents for chemical sensing. These approaches include chemical synthesis, using catalysts from biological systems, partitioning, aptamers, antibodies and molecularly imprinted polymers. The latter three approaches are general in that they can be applied with a large number of analytes, both proteins and smaller molecules like drugs and hormones. Aptamers and antibodies bind analytes rapidly while molecularly imprinted polymers bind much more slowly. Most molecularly imprinted polymers, formed by polymerizing in the presence of a template, contain a high level of covalent crosslinker that causes the polymer to form a separate phase. This results in a material that is rigid with low affinity for analyte and slow binding kinetics. Our approach to templating is to use predominantly or exclusively noncovalent crosslinks. This results in soluble templated polymers that bind analyte rapidly with high affinity. The biggest challenge of this approach is that the chains are tangled when the templated polymer is dissolved in water, blocking access to binding sites.

scholarly journals Redox initiation in semicontinuous polymerization to search for specific mechanical properties of copolymers

e-Polymers ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 613-623
Author(s):  
José Manuel Sandoval-Díaz ◽  
Francisco Javier Rivera-Gálvez ◽  
Marta Fernández-García ◽  
Carlos Federico Jasso-Gastinel
Keyword(s):  
Low Cost ◽  
Mechanical Analysis ◽  
Industrial Applications ◽  
Size Exclusion ◽  
Proton Nuclear Magnetic Resonance ◽  
Polymerization Reaction ◽  
Redox Initiation ◽  
Initiation System ◽  
Feeding Profile ◽  
Chain Composition

AbstractIn this work, for a semicontinuous emulsion polymerization reaction, it is shown that using a redox initiation system at 40°C, substantial modifications in copolymer chain composition with conversion can be easily obtained. To test controllable trajectories for comonomer feeding, linear and parabolic profiles were chosen to get different types of chain composition variations for the 50/50 w/w styrene/n-butyl acrylate system. For the “forced composition copolymers,” the molecular weight averages and distribution were obtained by size exclusion chromatography. The composition along conversion was followed by proton nuclear magnetic resonance to determine the weight composition distribution (WCD) of the copolymer chains. Mechanodynamic (dynamic-mechanical analysis), tensile, and hardness tests exhibited consistent results depending on the WCD that outcomes from the respective feeding profile. The results confirm that this methodology is of great potential for industrial applications when looking for synergy in copolymer properties, and low-cost processes.

scholarly journals Enhancing the self-recovery and mechanical property of hydrogels by macromolecular microspheres with thermal and redox initiation systems

RSC Advances ◽  
2017 ◽  
Vol 7 (26) ◽  
pp. 16015-16021 ◽  
Author(s):  
Chang Huang ◽  
Yifan Li ◽  
Lijie Duan ◽  
Linhui Wang ◽  
Xiuyan Ren ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Mechanical Behavior ◽  
The Self ◽  
Redox Initiation ◽  
Initiation System

A redox initiation system was used to efficiently enhance the mechanical behavior of macromolecular microsphere hydrogels.

Preparation of core–shell attapulgite particles by redox-initiated surface reversible addition–fragmentation chain transfer polymerization via a “graft from” approach

RSC Advances ◽  
2016 ◽  
Vol 6 (17) ◽  
pp. 14120-14127 ◽  
Author(s):  
Haicun Yang ◽  
Sheng Xue ◽  
Ji Pan ◽  
Fanghong Gong ◽  
Hongting Pu
Keyword(s):  
Polymethyl Methacrylate ◽  
Chain Transfer ◽  
Core Shell ◽  
Redox Initiation ◽  
Initiation System ◽  
System P ◽  
Reversible Addition ◽  
Chain Transfer Polymerization

Polymethyl methacrylate layer was grown uniformly from attapulgite by using surface-initiated reversible addition–fragmentation chain transfer polymerization via redox initiation system.

Characterization and Evaluation of Binding Properties of Salvianolic Acid a Imprinted Polymers Prepared by Precipitation Polymerization

2011 ◽  
Vol 239-242 ◽  
pp. 2423-2426
Author(s):  
Lin Min Zhu ◽  
Shao Ping Fu ◽  
Lin Ying Li ◽  
Jing Bo Zhu
Keyword(s):  
Dissociation Constants ◽  
Precipitation Polymerization ◽  
Scatchard Analysis ◽  
Template Molecule ◽  
Binding Properties ◽  
Imprinted Polymers ◽  
Salvianolic Acid ◽  
Salvianolic Acid A ◽  
Equilibrium Dissociation Constants ◽  
Equilibrium Dissociation

Molecularly imprinted polymers (MIPs) were synthesized by precipitation polymerization using salvianolic acid A (Sal A), acrylamide (AA), ethylene glycol dimethacrylate (EGDMA) and acetonitrile as template molecule, functional monomer, cross-linker and solvent, respectively. The morphology of the obtained polymers was characterized by scanning electron microscopy (SEM). The effect of different polymerization conditions (solvent volume, solvent and template amount) on the size and shape of particles was investigated. The binding properties of the imprinted polymers were evaluated through the equilibrium rebinding experiments. Scatchard analysis revealed that two classes of binding sites were formed in the imprinted polymers with equilibrium dissociation constants of 0.33 μmol·mL-1and 0.07 μmol·mL-1, respectively. Besides Sal A, two structurally related compounds, protocatechuic aldehyde (Pra) and salvianolic acid B (Sal B), were employed for molecular selectivity tests. The results indicated that the imprinted polymers exhibited good selectivity and specificity toward Sal A.

scholarly journals Synthesis of Molecularly Imprinted Polymerand its Molecular Recognition PropertiesofN-Acetylneuraminic Acid

2007 ◽  
Vol 4 (4) ◽  
pp. 611-619 ◽  
Author(s):  
Hsin-Hung Pan ◽  
Wen-Chien Lee ◽  
Chin-Yin Hung ◽  
Ching-Chiang Hwang
Keyword(s):  
Specific Binding ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Acetylneuraminic Acid ◽  
Binding Isotherms ◽  
Molecular Imprinting Technique ◽  
Guest System ◽  
Cross Linker ◽  
Principal Advantage

A molecular imprinting technique was applied in this work to detectN-acetylneuraminic acid (Neu5Ac) and its analogue structure. Twomolecularly imprinted polymers (MIP) were prepared using Neu 5Ac as the template molecule, as well as methacrylic acid (MAA) or 4-vinylpyridine (4-Vpy) and ethyleneglycol dimethacrylate (EGDMA) as the functionalmonomer and cross-linker, respectively. Free radical polymerization was carried out at 4°C under UV radiation or thermal (60°C) polymerization. MIP thus obtained were ground into 11∼25µm and 25-44µm. The binding results from Neu5Ac solution, mannose (Man) solution andN-acetyl-Dmannosamine (ManNAc) solution performed by Neu5Ac-MIP showed specific binding toward Neu5Ac rather than other analogue compounds on the host-guest system. The values of capacity for Neu5Ac-MIP were measured and experimental results were further used for simulation to obtain the binding isotherms. The principal advantage of this method is thatNeu5Ac- MIP can recognize Neu5Ac and its analogue compounds.

Practice and Synthetize Molecularly Imprinted Polymers for Seperating Target Neuro-Protective Compounds from TCM with Less Pollution

2014 ◽  
Vol 955-959 ◽  
pp. 239-242
Author(s):  
Ping Geng ◽  
Qing Shan Liu ◽  
Kebaituli Gulibanumu ◽  
Xu Li ◽  
Ke Qin Li ◽  
...  
Keyword(s):  
Electron Microscope ◽  
Molecularly Imprinted Polymers ◽  
Extraction Method ◽  
Template Molecule ◽  
Ginsenoside Rb1 ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Synthetic Materials ◽  
Scatchard Equation ◽  
Environmentally Friendly Method

Molecularly imprinted polymers (MIPs) are synthetic materials that can be the environmental protection extraction method in TCM research and industry. They can overcome the defects of traditional extract methods and environmental pollution. In our research, MIPs were prepared by precipitation polymerization with neuro-protective picroside I and ginsenoside Rb1 as the template molecule. Moreover, the morphology of MIPs was characterized by electron microscope scanning and the static adsorption capacity was measured by the Scatchard equation. Finally, MIPs were made into MIP-SPE columns to enrich the template molecule and its analogues comparing with C18-SPE column and the results show that MIPs have good affinity and selectivity towards the Rb1 and Picroside I in SPE columns. This research may offer a more environmentally friendly method to extract active compounds in the traditional herbal.

scholarly journals Synthesis and characterization of genistein magnetic molecularly imprinted polymers and their application in soy sauce products

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ziqi Xie ◽  
Yunjing Luo ◽  
Zhen Na ◽  
Wei Zhang ◽  
Yufei Zong
Keyword(s):  
Electron Microscopy ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Soy Sauce ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Magnetic Molecularly Imprinted Polymers ◽  
Relative Standard ◽  
Surface Molecular Imprinting Technique

AbstractIn this study, a novel method based on genistein magnetic molecularly imprinted polymers (Gen-MMIPs) was developed utilizing a surface molecular imprinting technique, in which genistein was used as the template molecule and Fe3O4 was used as the carrier. The synthesis of Gen-MMIPs was characterized by using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), which indicated that the diameter of the Gen-MMIPs was approximately 500 nm. Via analysis with a vibrating sample magnetometer (VSM), the saturation magnetization of Gen-MMIPs was determined to be 24.79 emu g−1. Fourier transform infrared (FT-IR) spectroscopy showed that polymer groups were on the surface of the magnetic carrier. Adsorption experiments suggested that the genistein adsorption capability of Gen-MMIPs was 5.81 mg g−1, and adsorption equilibrium was achieved within 20 min. Gen-MMIPs as dispersive solid-phase extraction (dSPE) adsorbents combined with HPLC were used to selectively separate genistein in soy sauce samples, and the recoveries ranged from 85.7 to 88.5% with relative standard deviations (RSDs) less than 5%, which proved that this method can be used for the detection of genistein residues in real samples.

scholarly journals Synthesis and Characterization of Genistein Magnetic Molecularly Imprinted Polymers and Its Application in Soy Sauce Products

2021 ◽  
Author(s):  
Ziqi Xie ◽  
Yunjing Luo ◽  
Zhen Na ◽  
Wei Zhang ◽  
Yunfei Zong
Keyword(s):  
Electron Microscopy ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Soy Sauce ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Magnetic Molecularly Imprinted Polymers ◽  
Relative Standard ◽  
Surface Molecular Imprinting Technique

Abstract In this study, a novel method based on genistein magnetic molecularly imprinted polymers (Gen-MMIPs) was developed by surface molecular imprinting technique, in which genistein was used as the template molecule and Fe3O4 was used as the carrier. The synthesis of Gen-MMIPs were characterized by using of scanning electron microscopy (SEM) and transmission electron microscopy (TEM), which indicated the diameters of Gen-MMIPs were about 500 nm. Through the technique of vibrating sample magnetometer (VSM), the saturation magnetization of Gen-MMIPs were detected as 24.79 emu/g. Fourier transform infrared (FR-IR) spectroscopy showed that polymer groups were on the surface of the magnetic carrier. Adsorption experiment suggested the adsorption capability of Gen-MMIPs to genistein were 1.55 mg/g, and 2 the adsorption equilibrium was achieved within 20 min. Gen-MMIPs as dispersive solid-phase extraction adsorbent combined with HPLC was used to selectively separate genistein in soy sauce samples, the recoveries were ranged from 85.7% to 88.5% with the relative standard deviations (RSD) less than 5%, which proved this method can be used for the detection of genistein residues in real samples.

scholarly journals Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4328
Author(s):  
Martyna Pajewska-Szmyt ◽  
Ewelina Biniewska ◽  
Bogusław Buszewski ◽  
Renata Gadzała-Kopciuch
Keyword(s):  
Breast Milk ◽  
Limit Of Detection ◽  
Polymer Surface ◽  
Magnetic Core ◽  
Template Molecule ◽  
Limit Of Quantification ◽  
Rapid Separation ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Polymer Sorbents

Magnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavity on their polymer surface, enabling the lock–key model interactions to occur. In addition, the magnetic core provides superparamagnetic properties that allow rapid separation of the sorbent from the sample solution. Such a combination of imprinted polymers with a magnetic core has an innovative influence on the development of separation techniques. Hence, the present study describes the synthesis of MMIPs with 17β-estradiol used as a template molecule in the production of imprinted polymers. The as-prepared sorbent was used for a sorption/desorption study of five parabens from breast milk samples. The obtained results were characterized by sorption efficiency exceeding 92%, which shows the high affinity of the analytes to the functional groups on the sorbent. The final determination of the selected analytes was done with high-performance liquid chromatography using a fluorometric detector. The determined linearity ranges for selected parabens were characterized by high determination coefficients (r2 from 0.9992 to 0.9999), and the calculated limit of detection (LOD) and limit of quantification (LOQ) for the identified compounds were low (LOD from 1.1–2.7 ng mL−1; LOQ from 3.6–8.1 ng mL−1), which makes their quantitative analysis in real samples feasible.

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