scholarly journals Linoleic acid-rich fats reduce atherosclerosis development beyond its oxidative and inflammatory stress-increasing effect in apolipoprotein E-deficient mice in comparison with saturated fatty acid-rich fats

2005 ◽  
Vol 94 (6) ◽  
pp. 896-901 ◽  
Author(s):  
Masao Sato ◽  
Kenichi Shibata ◽  
Run Nomura ◽  
Daisuke Kawamoto ◽  
Rika Nagamine ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Saturated Fatty Acid ◽  
Liver Cholesterol ◽  
Inflammatory Stress ◽  
Cholesterol Levels ◽  
Inflammatory Status ◽  
Apo E ◽  
Deficient Mice

The relative benefit of replacing saturated fatty acid with linoleic acids is still being debated because a linoleic acid-enriched diet increases oxidative and inflammatory stresses, although it is associated with a reduction in serum cholesterol levels. The present study was conducted to evaluate the effect of dietary supplementation of linoleic acid-rich (HL) fat, compared with a saturated fatty acid-rich (SF) fat on atherosclerotic lesion areas, serum and liver cholesterol levels, oxidative stress (urinary isoprostanes and serum malondialdehayde) and inflammatory stress (expression of aortic monocyte chemoattractant protein-1; MCP-1) in apo E-deficient mice. Male and female apo E-deficient mice (8 weeks old; seven to eight per group) were fed an AIN-76-based diet containing SF fat (50 g palm oil and 50 g lard/kg) or HL fat (100 g high-linoleic safflower-seed oil/kg) for 9 weeks. Compared with the SF diet, the HL diet lowered atherosclerosis (P<0·05). It reduced serum total cholesterol levels (P<0·05), increased HDL-cholesterol levels (P<0·05) and lowered liver esterified cholesterol levels (P<0·01). The HL diet-fed mice showed increased expression of MCP-1 mRNA (P<0·05), serum levels of malondialdehayde (P<0·05) and urinary excretion of 2,3-dinor-5,6-dihydro-8-iso-prostaglandin F2α;P<0·05). These results suggest that having biomarkersin vivofor oxidative stress and inflammatory status of endothelial cells does not necessarily indicate predisposition to an increased lesion area in the aortic root in apo E-deficient mice fed an HL or SF diet.

scholarly journals Grape extract and α-Tocopherol effect in cardiovascular disease model of Apo E -/- Mice

2011 ◽  
Vol 26 (4) ◽  
pp. 253-260 ◽  
Author(s):  
Maria do Carmo Gouveia Peluzio ◽  
Tatiana Fiche Salles Teixeira ◽  
Vanessa Patrocínio Oliveira ◽  
Céphora Maria Sabarense ◽  
Cristina Maria Ganz Chaves Dias ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Morphological Analysis ◽  
Saturated Fatty Acids ◽  
Disease Model ◽  
Atherogenic Diet ◽  
Fecal Excretion ◽  
Liver Cholesterol ◽  
Grape Extract ◽  
Cholesterol Levels ◽  
Apo E

PURPOSE: To verify the effect of consumption of grape extract isolated or combined with α-tocopherol supplementation on atherosclerosis model with Apo E -/- mice. METHODS: After six weeks of atherogenic diet, Apo E -/- mice were divided into the following groups: Control, Grape, Tocopherol and Grape plus Tocopherol. The treatment progressed for 11 weeks when animals were submitted to euthanasia. RESULTS: All the treatments presented hypocholesterolemic effect with reduction of serum and liver cholesterol levels. This effect was parallel to an increase in the fecal excretion of cholesterol. There was also a higher fecal excretion of saturated fatty acids in groups receiving grape extract or α-tocopherol. All the groups treated presented a tendency to show higher levels of vitamin E. The fatty acid profile showed a tendency for monounsaturated fatty acid preservation after grape extract and α-tocopherol consumption. Morphological analysis revealed a lower degree of evolution of the atherosclerotic plaque of the animals that were fed α-tocopherol combined with grape extract, even when no difference was found in the size of the largest lesion. CONCLUSION: A synergistic effect between the polyphenols and α-tocopherol was observed, resulting in diminished evolution of atherosclerosis and a greater beneficial effect on atherosclerosis than the isolated consumption of antioxidants.

Oxidation of Linoleic Acid and Methyl Linoleate Mixed with Saturated Fatty Acid or its Methyl Ester

LWT ◽  
2001 ◽  
Vol 34 (4) ◽  
pp. 234-238 ◽  
Author(s):  
Eiichiro Ishido ◽  
Yasumasa Minemoto ◽  
Shuji Adachi ◽  
Ryuichi Matsuno
Keyword(s):  
Fatty Acid ◽  
Linoleic Acid ◽  
Methyl Ester ◽  
Methyl Linoleate ◽  
Saturated Fatty Acid

scholarly journals Quality traits and fatty acid composition in meat of Hair Goat and Saanen  ×  Hair Goat (G<sub>1</sub>) crossbred kids fattened in different systems

2021 ◽  
Vol 64 (2) ◽  
pp. 305-314
Author(s):  
Hacer Tüfekci ◽  
Mustafa Olfaz
Keyword(s):  
Fatty Acid ◽  
Linoleic Acid ◽  
Meat Quality ◽  
Saturated Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Conjugate Linoleic Acid ◽  
Monounsaturated Fatty Acid ◽  
Quality Traits ◽  
Total Saturated Fatty Acid ◽  
Meat Quality Traits

Abstract. In this study, meat quality traits and fatty acid compositions of Hair Goat and Saanen × Hair Goat (G1) crossbred kids fattened under intensive, semi-intensive and extensive conditions were determined. For meat quality traits, differences in pH24 h, pH45 min, drip loss, water holding capacity, cooking loss and Warner–Bratzler peak shear force values of the experimental groups were not found to be significant. According to colour measurements at the 0th and 45th minute, the extensive fattening group of Hair Goat kids had greater lightness (L∗) values and the intensive fattening group of Hair Goat kids had greater redness (a∗) values. For intensive, semi-intensive and extensive fattening groups of Hair Goat kids, total saturated fatty acid contents of longissimus dorsi (LD) muscle samples were respectively measured as 19.28 %, 23.75 % and 23.35 %. Total monounsaturated fatty acid contents were respectively measured as 67.30 %, 66.22 % and 65.72 %. Total polyunsaturated fatty acid contents were respectively measured as 5.46 %, 3.06 % and 3.16 % and conjugate linoleic acid contents were respectively measured as 0.48 %, 0.55 % and 0.65 %. For intensive, semi-intensive and extensive fattening groups of Saanen × Hair Goat (G1) kids, total saturated fatty acid contents of LD muscle samples were respectively measured as 21.01 %; 21.98 %, 19.10 %; total monounsaturated fatty acid contents were respectively measured as 64.04 %, 64.33 %, 52.44 %. Total polyunsaturated fatty acid contents were respectively measured as 3.53 %, 4.89 % and 4.84 % and conjugate linoleic acid contents were respectively measured as 0.52 %, 0.58 % and 0.73 %. It was concluded that the extensive fattening group had greater conjugated linoleic acid contents than the other fattening groups.

scholarly journals Modulation of plasma and tissue cholesterol and fatty acid composition by feeding flax and canola seeds and oils to rats

1991 ◽  
Vol 71 (4) ◽  
pp. 1207-1214 ◽  
Author(s):  
J. Sim ◽  
E. Nwokolo ◽  
Z. Jiang
Keyword(s):  
Fatty Acid ◽  
Plasma Cholesterol ◽  
Dietary Treatment ◽  
Liver Cholesterol ◽  
Canola Meal ◽  
Flax Seed ◽  
Sprague Dawley ◽  
Flax Oil ◽  
Cholesterol Levels ◽  
Tissue Lipids

Intact full-fat oil seeds might be more resistant to oxidation than extracted and refined oils and might therefore be used as sources of dietary fat. The present study was conducted to examine and compare the influence of feeding full-fat flax and canola seeds and oils on the plasma and tissue lipids of the rat. Male weanling Sprague Dawley rats (n = 4) were housed individually in metabolic cages and fed isoenergetic and isonitrogenous diets containing full-fat flax (FFF), flax meal + flax oil (FO), full-fat canola (FFC), canola meal + canola oil (CO), and soybean meal + animal tallow (AT). After 6 wk of feeding, plasma cholesterol levels were significantly (P < 0.05) reduced in rats fed flax diets (FF and FO) but not in those fed canola diets (FFC and CO). Liver cholesterol levels were not affected by dietary treatment. The highest levels of α-linolenic acid (LNA) and eicosapentaenoic acid (EPA) were recorded in the plasma, liver, heart and epididymal fat of rats fed the flax-containing diets. Intermediate levels of LNA and EPA in plasma and tissues were found in rats fed canola-containing diets. Rats fed flax diets had less arachidonic acid (AA) in plasma, liver, and heart tissues than those fed control and canola diets, indicating inhibition of AA synthesis by high dietary LNA provided by full-fat flax seed and flax oil. These results demonstrated that full-fat flax and canola seeds could be used as sources of dietary LNA to modify plasma and tissue lipids. Key words: Flax seed, canola seed, cholesterol, fatty acid, rat

Divergent effects of folic acid administration on inflammatory status and cholesterol levels in apoE deficient mice

2014 ◽  
Vol 173 (3) ◽  
pp. 608-609 ◽  
Author(s):  
Dimitris Tousoulis ◽  
Polina Kourkouti ◽  
Alexandros Briasoulis ◽  
Georgia Vogiatzi ◽  
Aggeliki Valatsou ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cholesterol Levels ◽  
Inflammatory Status ◽  
Deficient Mice ◽  
Acid Administration
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