scholarly journals Effect of sex hormones on fasting serum triglycerides in baboons given high-sucrose diets

1971 ◽  
Vol 25 (3) ◽  
pp. 323-331 ◽  
Author(s):  
T. M Coltart ◽  
I Macdonald
Keyword(s):  
Sex Hormones ◽  
Serum Triglyceride ◽  
Sucrose Intake ◽  
Serum Concentrations ◽  
Fasting Serum ◽  
Serum Triglycerides ◽  
Male And Female ◽  
Sucrose Diet ◽  
Serum Triglyceride Concentration ◽  
High Sucrose

1. The incorporation of [14C]sucrose in to serum triglyceride was shown to increase in both male and female baboons after a period of high sucrose intake. During the same period of high sucrose intake there was an increase in the fasting serum triglyceride concentration of the male baboons but not of the females.2. When the male baboons were given a parenteral oestrogen preparation in addition to the sucrose diet the increase in fasting serum triglycerides was greatly reduced but there was little alteration in the extent of the incorporation of sucrose into serum triglyceride compared to that with the diet and no oestrogen.3. A parenteral testosterone preparation given to the female baboons in addition to sucrose diet had no effect on either the extent of incorporation of sucrose into triglyceride the fasting serum concentrations of triglyceride.4. The findings suggest that the differing patterns of fasting triglyceride response in the male and female baboons to the sucrose diet may have resulted from oestrogen enhancing the removal of triglyceride from the serum of the female animals.

Influence of Dietary Sucrose on Glucose and Fructose Tolerance and Triglyceride Synthesis in the Baboon

1970 ◽  
Vol 38 (4) ◽  
pp. 427-437 ◽  
Author(s):  
T. M. Coltart ◽  
J. N. Crossley
Keyword(s):  
Glucose Tolerance ◽  
Peripheral Blood ◽  
Specific Activity ◽  
Serum Triglyceride ◽  
Triglyceride Synthesis ◽  
Male And Female ◽  
Effect Relationship ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

1. Male and female baboons were fed a 75% sucrose/fat free diet for 13 weeks. At the end of this period, and when tested by a sucrose meal, the glucose tolerance was improved, but the fructose tolerance impaired. 2. There was no difference between the male and female baboons with regard to the changes observed in glucose tolerance. The impairment of fructose tolerance as a result of the sucrose diet was more marked in the males than in the females. 3. By labelling the sucrose meals uniformly with 14C, a correlation was observed between the level of peripheral blood fructose attained and the degree to which 14C-triglyceride appeared in the serum. No such correlation was found with glucose. 4. A cause-and-effect relationship between fructose tolerance and triglyceride specific activity was demonstrated by means of a high sucrose diet. The resulting impairment of fructose tolerance was reflected by a corresponding increase in triglyceride specific activity. The improvement in glucose tolerance under the same dietary conditions bore no relationship to the change in triglyceride specific activity. 5. Fructose was incorporated into serum triglyceride to a greater extent in the male baboons than in the females because of the higher levels of blood fructose attained in the male animals.

scholarly journals Effects of isocaloric exchange of dietary sucrose and starch on fasting serum lipids, postprandial insulin secretion and alimentary lipaemia in human subjects

1972 ◽  
Vol 27 (2) ◽  
pp. 395-405 ◽  
Author(s):  
J. I. Mann ◽  
A. S. Truswell
Keyword(s):  
Insulin Secretion ◽  
Serum Lipids ◽  
Human Subjects ◽  
Insulin Response ◽  
Serum Triglyceride ◽  
Cholesterol Concentration ◽  
Immunoreactive Insulin ◽  
Adult Males ◽  
Fasting Serum ◽  
Serum Triglycerides

1. Fasting serum cholesterol and triglyceride, and post prandial insulin secretion and lipaemia were measured in human subjects in a metabolic ward, who were given an ordinary diet (diet 1) in which the sucrose was isocalorically replaced by starch (diet 2) or vice versa. The subjects were nine healthy normolipaemic adult males. In eight of these subjects the effect of sucrose calorie reduction (diet 3) on fasting serum lipids was also studied.2. When starch replaced sucrose, there were no singnificant differences in fasting serum lipid concentrations or immunoreactive insulin or in the insulin response and alimentary lipaemia after a standard mixed breakfast.3. Serum triglyceride concentration fell and cholesterol concentration rose during the period of sucrose (and calorie) restriction.4. After lunch and supper on the first two diets (when different carbohydrates were given) the lipaemic response was larger and the insulin response smaller after meals containing sucrose.5. Thus, there was no difference between concentrations of fasting serum lipids when starch replaced sucrose at 23% total calories, but the concentrations of serum triglycerides were higher after individual mixed meals containing sucrose.6. There were no significant differences in the fatty acid patterns of serum lipids on the different diets.

scholarly journals Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2914
Author(s):  
Natacha Fourny ◽  
Carole Lan ◽  
Monique Bernard ◽  
Martine Desrois
Keyword(s):  
Reperfusion Injury ◽  
Glucose Intolerance ◽  
Physiological Response ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
High Fat ◽  
Male And Female ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Prediabetes is a strong predictor of type 2 diabetes and its associated cardiovascular complications, but few studies explore sexual dimorphism in this context. Here, we aim to determine whether sex influences physiological response to high-fat high-sucrose diet (HFS) and myocardial tolerance to ischemia-reperfusion injury. Male and female Wistar rats were subjected to standard (CTRL) or HFS diet for 5 months. Then, ex-vivo experiments on isolated perfused heart model were performed to evaluate tolerance to ischemia-reperfusion injury. HFS diet induced fasting hyperglycemia and increased body fat percent to a similar level in both sexes. However, glucose intolerance was more pronounced in female HFS. Cholesterol was increased only in female while male displayed higher level of plasmatic leptin. We observed increased heart weight to tibia length ratio only in males, but we showed a similar decrease in tolerance to ischemia-reperfusion injury in female and male HFS compared with respective controls, characterized by impaired cardiac function, energy metabolism and coronary flow during reperfusion. In conclusion, as soon as glucose intolerance and hyperglycemia develop, we observe higher sensitivity of hearts to ischemia-reperfusion injury without difference between males and females.

scholarly journals Association of Serum Triglycerides and Total Cholesterol levels with Hypertension in Adult Female

2019 ◽  
Vol 7 (1) ◽  
pp. 35-39
Author(s):  
Nahid Yeasmin ◽  
Qazi Shamima Akhter ◽  
Sayeeda Mahmuda ◽  
Sharmin Nahar ◽  
Mahmuda Abira ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Total Cholesterol ◽  
Diastolic Blood Pressure ◽  
Adult Female ◽  
Serum Triglyceride ◽  
Control Group ◽  
Fasting Serum ◽  
Serum Triglycerides ◽  
Medical College ◽  
Female Subjects

Hyperlipidemia is one of the most widespread medical disorder in female and its complications are increasing all over the world, leading to life threatening medical problems like cardiovascular diseases, stroke and peripheral vascular diseases. An association between hyperlipidemia and hypertension has been identified. The study was carried out to observe the association of serum triglycerides and total cholesterol level with hypertension in adult female subjects. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of sixty female subjects were selected with age ranging from 30 to 50 years. Among them 30 female subjects with hypertension were included from the out-patient department of Medicine, Dhaka Medical College Hospital, Dhaka as study group (B) and 30 apparently healthy females were taken as control group (A) for comparison. Estimation of fasting serum triglycerides (TG) and total cholesterol (TC) levels were done by enzymatic method in the Department of Physiology, Dhaka Medical College Dhaka in both groups. Systolic blood pressure and diastolic blood pressure of all participants were recorded by standard method. Data were analyzed by Unpaired Student’s- test and Pearson's correlation co-efficient (r) test as applicable. The values of fasting serum TG level were significantly higher in subjects with hypertension than those of control. Fasting serum TC level was significantly higher in subjects with hypertension in comparison to controls also. In subjects with hypertension fasting serum TG and fasting serum TC levels were higher and showed positive correlation with systolic and diastolic blood pressure. Present study revealed that systolic and diastolic blood pressure has positive relationship with fasting serum triglyceride (TG) and fasting serum cholesterol (TC) levels. Bangladesh Crit Care J March 2019; 7(1): 35-39

scholarly journals Effect of High Sucrose Diet on Histopathological Indicators Associated With Nonalcoholic Fatty Liver Disease in Male and Female C57bl/6N Mice

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 461-461
Author(s):  
Melissa Vega-Burgueño ◽  
Marcela Vergara-Jiménez ◽  
Lorenzo Osuna-Ramirez ◽  
Edith Torres-Montoya ◽  
José Zazueta-Moreno ◽  
...  
Keyword(s):  
Inflammatory Infiltrate ◽  
Metabolic Stress ◽  
Research Network ◽  
Standard Diet ◽  
Score System ◽  
Male And Female ◽  
Histological Score ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Abstract Objectives To evaluate the effect of a high sucrose diet on the histopathological indicators related to NAFLD in male and female mice of the C57bl/6N strain. Methods Forty male and female mice of the C57bl/6N strain were randomly divided into four experimental groups: Control male (CMG) and female groups (CFG) with a standard diet (Rodent Chow) and tap water, as well as sucrose male (SMG) and female groups (SFG) which received standard diet and a 50% sucrose water solution. All the groups were fed ad libitum to one of the two different diets for 20 weeks. After 20 weeks, mice were sacrificed. Blood, hepatic and adipose tissues were collected for analyses. Hepatic tissues were sectioned and stained with hematoxylin and eosin. Samples were examined by light microscopy to analyze liver damage. The non-alcoholic steatohepatitis (NASH) degree was determined according to the histological score system proposed by the clinical research network of NASH. Results In hepatic histological samples of MCG, a normal parenchyma formed by hepatocytes with a conserved architecture was observed, in which the cytoplasm and the nucleus can be appreciated. According to the histological score system of the clinical research network of NASH, it was not considered into any NASH grade. FCG showed few microvesicles in parenchyma, developing grade 1 of NASH, with microvesicular steatosis, not considered pathological. Compared to sucrose groups, in MSG were observed presence of moderate microvesicular steatosis, moderate metabolic stress, and glycogen condensation. No presence of inflammatory infiltrate, inflammation, or granulomas, developing grade 4 of NASH. On the other hand, FSG showed a wide spread of macrovesicular steatosis (zones 1, 2 and 3 of liver acinus), presence of inflammatory infiltrate and granulomas in the liver parenchyma. High metabolic stress in the three zones and glycogen condensation, with the loss of histological architecture, positioning in grade 6 of NASH. Conclusions A high sucrose diet contributed to develop NAFLD in mice of the C57bl/6n strain. MSG showed light to moderate degree of NAFLD, whereas FSG showed a moderate to a high degree of NAFLD (steatosis and NASH) related to sucrose consumption. Funding Sources This work was supported by the Universidad Autónoma de Sinaloa.

scholarly journals 178EMBRYO QUALITY AND COLOR IN HOLSTEIN FRIESIAN AND BELGIAN BLUE CATTLE IN RELATION TO DONOR BLOOD CHOLESTEROL AND TRIGLYCERIDES

2004 ◽  
Vol 16 (2) ◽  
pp. 211 ◽  
Author(s):  
J.L.M.R. Leroy ◽  
L. Goossens ◽  
A. Geldhof ◽  
T. Vanholder ◽  
G. Opsomer ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Embryo Quality ◽  
Serum Triglyceride ◽  
Serum Total Cholesterol ◽  
Blood Cholesterol ◽  
Bovine Embryo ◽  
Serum Concentrations ◽  
Donor Blood ◽  
Serum Triglycerides ◽  
Holstein Friesian

Bovine embryo freezability is closely linked with quality and differs between cow breeds (Visintin JA et al., 2002 Theriogenology 57, 345–359). Dark embryos have a bad freezability, resulting in low pregnancy rates (Hill BR and Kuehner LF, 1998 Theriogenology 49, 168). Excessive accumulation of lipid droplets in dark embryos is suggested to be the cause of this inferior embryo quality and in turn may be influenced by the biochemical composition of the embryonic environment. In a field trial we studied the relationship between donor breed (Holstein Friesian dairy cows v. Belgian Blue beef cows), donor serum total cholesterol and triglyceride concentration, embryo quality and embryo color. The preliminary results are presented. Blood was drawn from Holstein Friesian (HF) (n=74) and Belgian Blue cows (BB) (n=55) prior to embryo flushing on Day 7 after superovulation and subsequent insemination. Serum was analyzed for total cholesterol and triglycerides using commercial photometric assays. Embryos were scored individually by the same operator for quality (excellent to bad: score 1 to 4) and for color: light (L), medium (M) or dark (D) using a binocular stereomicroscope (40X). Student’s t-test, chi-square test and Spearman correlations were used when appropriate. Holstein Friesian cows yielded significantly more embryos (±SEM) per flushing than did BB (6.0±0.59 v. 4.2±0.44) (P<0.05). However, significantly more HF embryos were classified as dark compared to the BB embryos (L, M, D: 39.4%, 43.8% and 16.8% v. 80.5%, 19.5% and 0% of the HF and BB embryos, respectively) (P<0.05). Significantly more BB embryos showed an excellent morphological quality (55.0% of BB embryos compared to 28.4% of HF embryos) (P<0.05). The serum concentrations (±SEM) of total cholesterol (148±5.9mgdL−1 v. 106±4.1mgdL−1) were significantly higher and the serum concentrations of triglycerides (19.6±0.71mgdL−1 v. 28.4±3.34mgdL−1) were significantly lower in HF compared to BB (P<0.05). Within the HF breed, there was a significant positive correlation between donor blood total cholesterol and the color of each embryo (r=0.545) and a negative correlation between serum triglycerides and embryo color (r=−0.484) (P<0.05). In our study, embryo quality and color as well as serum total cholesterol and triglyceride concentrations are clearly influenced by donor breed. Within the HF breed, darker embryos originate from donors with higher serum total cholesterol and lower serum triglyceride levels. These preliminary data suggest that factors influencing total cholesterol and triglyceride concentrations in the donor blood (e.g. breed, milk yield, nutrition) may influence embryo color and thus embryo lipid content, freezability and subsequent pregnancy rate.

scholarly journals Effects of Maternal Sucrose Consumption on Inflammation and Steroids in the Placenta and Fetal Brain

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A500-A500
Author(s):  
Desiree R Seib ◽  
George V Kachkovski ◽  
Tamara S Bodnar ◽  
Abby C Collier ◽  
Kiran K Soma
Keyword(s):  
Amniotic Fluid ◽  
Adult Male ◽  
Fetal Brain ◽  
Male Offspring ◽  
Metabolic Effects ◽  
Sucrose Intake ◽  
Fetal Blood ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Abstract Consumption of sucrose (table sugar) is high in much of the world. The effects of a maternal diet high in sucrose on the placenta and fetal brain remain unknown. In rats, maternal consumption of sucrose at a human-relevant level has effects on the mother’s physiology and steroids, as well as long-lasting and sex-specific effects on the adult offspring’s brain and behavior. In the mothers, there are metabolic effects of sucrose intake, such as impaired glucose tolerance, increased liver lipids, and increased adipose inflammation. In rat dams, sucrose intake also decreases corticosterone levels in the blood but not in the brain. In the adult male offspring, preference for a high-sucrose diet and a high-fat diet increases due to maternal sucrose intake. In addition, maternal sucrose intake increases motivation for sugar rewards in a progressive ratio schedule of reinforcement in adult male offspring. In adult female offspring, corticosterone levels increase in the blood and brain as a result of maternal sucrose intake. In this study, we investigated the underlying mechanisms of the observed behavioral and endocrine effects in the adult offspring. Here, we examined cytokines and anti-inflammatory steroids in the placenta, amniotic fluid, and fetal blood and brain. In our model, we feed rat dams either a high-sucrose diet (26% of kCal) or an isocaloric, matched, control diet (1% sucrose) 10 weeks prior to and during gestation. At embryonic day 19 (E19), we collected maternal blood, placenta, amniotic fluid, fetal blood, and fetal brain. We use Palkovits punch to microdissect the placenta and fetal brain. Next, we use a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay, which is highly precise and specific, to measure multiple steroids (e.g. corticosterone, progesterone, estradiol, allopregnanolone). The method is highly sensitive, and we can measure neurosteroids in multiple regions of the fetal brain (e.g. prefrontal cortex, nucleus accumbens, hypothalamus, hippocampus). Moreover, we will examine steroidogenic enzymes and cytokines in the fetal brain and placenta. Preliminary data show distinct steroid patterns in amniotic fluid and fetal blood, as well as in different parts of the placenta.

Apolipoprotein E4 phenotype increases non-fasting serum triglyceride concentration in infants — the STRIP study

2000 ◽  
Vol 152 (1) ◽  
pp. 135-141 ◽  
Author(s):  
Anne Tammi ◽  
Tapani Rönnemaa ◽  
Jorma Viikari ◽  
Eero Jokinen ◽  
Helena Lapinleimu ◽  
...  
Keyword(s):  
Serum Triglyceride ◽  
Fasting Serum ◽  
Apolipoprotein E4 ◽  
Triglyceride Concentration ◽  
Serum Triglyceride Concentration
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