Influence of Dietary Sucrose on Glucose and Fructose Tolerance and Triglyceride Synthesis in the Baboon

1970 ◽  
Vol 38 (4) ◽  
pp. 427-437 ◽  
Author(s):  
T. M. Coltart ◽  
J. N. Crossley
Keyword(s):  
Glucose Tolerance ◽  
Peripheral Blood ◽  
Specific Activity ◽  
Serum Triglyceride ◽  
Triglyceride Synthesis ◽  
Male And Female ◽  
Effect Relationship ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

1. Male and female baboons were fed a 75% sucrose/fat free diet for 13 weeks. At the end of this period, and when tested by a sucrose meal, the glucose tolerance was improved, but the fructose tolerance impaired. 2. There was no difference between the male and female baboons with regard to the changes observed in glucose tolerance. The impairment of fructose tolerance as a result of the sucrose diet was more marked in the males than in the females. 3. By labelling the sucrose meals uniformly with 14C, a correlation was observed between the level of peripheral blood fructose attained and the degree to which 14C-triglyceride appeared in the serum. No such correlation was found with glucose. 4. A cause-and-effect relationship between fructose tolerance and triglyceride specific activity was demonstrated by means of a high sucrose diet. The resulting impairment of fructose tolerance was reflected by a corresponding increase in triglyceride specific activity. The improvement in glucose tolerance under the same dietary conditions bore no relationship to the change in triglyceride specific activity. 5. Fructose was incorporated into serum triglyceride to a greater extent in the male baboons than in the females because of the higher levels of blood fructose attained in the male animals.

scholarly journals Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2914
Author(s):  
Natacha Fourny ◽  
Carole Lan ◽  
Monique Bernard ◽  
Martine Desrois
Keyword(s):  
Reperfusion Injury ◽  
Glucose Intolerance ◽  
Physiological Response ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
High Fat ◽  
Male And Female ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Prediabetes is a strong predictor of type 2 diabetes and its associated cardiovascular complications, but few studies explore sexual dimorphism in this context. Here, we aim to determine whether sex influences physiological response to high-fat high-sucrose diet (HFS) and myocardial tolerance to ischemia-reperfusion injury. Male and female Wistar rats were subjected to standard (CTRL) or HFS diet for 5 months. Then, ex-vivo experiments on isolated perfused heart model were performed to evaluate tolerance to ischemia-reperfusion injury. HFS diet induced fasting hyperglycemia and increased body fat percent to a similar level in both sexes. However, glucose intolerance was more pronounced in female HFS. Cholesterol was increased only in female while male displayed higher level of plasmatic leptin. We observed increased heart weight to tibia length ratio only in males, but we showed a similar decrease in tolerance to ischemia-reperfusion injury in female and male HFS compared with respective controls, characterized by impaired cardiac function, energy metabolism and coronary flow during reperfusion. In conclusion, as soon as glucose intolerance and hyperglycemia develop, we observe higher sensitivity of hearts to ischemia-reperfusion injury without difference between males and females.

scholarly journals Anacardic acid mitigates liver fat accumulation and impaired glucose tolerance in mice fed a high‐fat and high‐sucrose diet

2020 ◽  
Vol 8 (2) ◽  
pp. 796-804 ◽  
Author(s):  
Sangwon Chung ◽  
Eun Ju Shin ◽  
Hyo‐Kyoung Choi ◽  
Jae Ho Park ◽  
Jin‐Taek Hwang
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Anacardic Acid ◽  
Liver Fat ◽  
High Fat ◽  
Fat Accumulation ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model

Diabetes ◽  
2014 ◽  
Vol 64 (6) ◽  
pp. 2254-2264 ◽  
Author(s):  
Guillaume Vial ◽  
Marie-Agnès Chauvin ◽  
Nadia Bendridi ◽  
Annie Durand ◽  
Emmanuelle Meugnier ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Mitochondrial Function ◽  
Mice Model ◽  
High Fat ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Effect of High Sucrose Diet on Histopathological Indicators Associated With Nonalcoholic Fatty Liver Disease in Male and Female C57bl/6N Mice

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 461-461
Author(s):  
Melissa Vega-Burgueño ◽  
Marcela Vergara-Jiménez ◽  
Lorenzo Osuna-Ramirez ◽  
Edith Torres-Montoya ◽  
José Zazueta-Moreno ◽  
...  
Keyword(s):  
Inflammatory Infiltrate ◽  
Metabolic Stress ◽  
Research Network ◽  
Standard Diet ◽  
Score System ◽  
Male And Female ◽  
Histological Score ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Abstract Objectives To evaluate the effect of a high sucrose diet on the histopathological indicators related to NAFLD in male and female mice of the C57bl/6N strain. Methods Forty male and female mice of the C57bl/6N strain were randomly divided into four experimental groups: Control male (CMG) and female groups (CFG) with a standard diet (Rodent Chow) and tap water, as well as sucrose male (SMG) and female groups (SFG) which received standard diet and a 50% sucrose water solution. All the groups were fed ad libitum to one of the two different diets for 20 weeks. After 20 weeks, mice were sacrificed. Blood, hepatic and adipose tissues were collected for analyses. Hepatic tissues were sectioned and stained with hematoxylin and eosin. Samples were examined by light microscopy to analyze liver damage. The non-alcoholic steatohepatitis (NASH) degree was determined according to the histological score system proposed by the clinical research network of NASH. Results In hepatic histological samples of MCG, a normal parenchyma formed by hepatocytes with a conserved architecture was observed, in which the cytoplasm and the nucleus can be appreciated. According to the histological score system of the clinical research network of NASH, it was not considered into any NASH grade. FCG showed few microvesicles in parenchyma, developing grade 1 of NASH, with microvesicular steatosis, not considered pathological. Compared to sucrose groups, in MSG were observed presence of moderate microvesicular steatosis, moderate metabolic stress, and glycogen condensation. No presence of inflammatory infiltrate, inflammation, or granulomas, developing grade 4 of NASH. On the other hand, FSG showed a wide spread of macrovesicular steatosis (zones 1, 2 and 3 of liver acinus), presence of inflammatory infiltrate and granulomas in the liver parenchyma. High metabolic stress in the three zones and glycogen condensation, with the loss of histological architecture, positioning in grade 6 of NASH. Conclusions A high sucrose diet contributed to develop NAFLD in mice of the C57bl/6n strain. MSG showed light to moderate degree of NAFLD, whereas FSG showed a moderate to a high degree of NAFLD (steatosis and NASH) related to sucrose consumption. Funding Sources This work was supported by the Universidad Autónoma de Sinaloa.

Effects of High Sucrose Diet and Its Components on Glucose Tolerance and Serum Lipids

2015 ◽  
pp. 159-167
Author(s):  
Shuji Inoue ◽  
Shinobu Satoh ◽  
Katsuaki Tanaka ◽  
Masato Egawa ◽  
Hajime Nagase ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Serum Lipids ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Effect of sex hormones on fasting serum triglycerides in baboons given high-sucrose diets

1971 ◽  
Vol 25 (3) ◽  
pp. 323-331 ◽  
Author(s):  
T. M Coltart ◽  
I Macdonald
Keyword(s):  
Sex Hormones ◽  
Serum Triglyceride ◽  
Sucrose Intake ◽  
Serum Concentrations ◽  
Fasting Serum ◽  
Serum Triglycerides ◽  
Male And Female ◽  
Sucrose Diet ◽  
Serum Triglyceride Concentration ◽  
High Sucrose

1. The incorporation of [14C]sucrose in to serum triglyceride was shown to increase in both male and female baboons after a period of high sucrose intake. During the same period of high sucrose intake there was an increase in the fasting serum triglyceride concentration of the male baboons but not of the females.2. When the male baboons were given a parenteral oestrogen preparation in addition to the sucrose diet the increase in fasting serum triglycerides was greatly reduced but there was little alteration in the extent of the incorporation of sucrose into serum triglyceride compared to that with the diet and no oestrogen.3. A parenteral testosterone preparation given to the female baboons in addition to sucrose diet had no effect on either the extent of incorporation of sucrose into triglyceride the fasting serum concentrations of triglyceride.4. The findings suggest that the differing patterns of fasting triglyceride response in the male and female baboons to the sucrose diet may have resulted from oestrogen enhancing the removal of triglyceride from the serum of the female animals.

scholarly journals Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice†

2017 ◽  
Vol 96 (2) ◽  
pp. 435-445 ◽  
Author(s):  
Kathleen A. Pennington ◽  
Nicola van der Walt ◽  
Kelly E. Pollock ◽  
Omonseigho O. Talton ◽  
Laura C. Schulz
Keyword(s):  
Maternal Health ◽  
Glucose Tolerance ◽  
Acute Exposure ◽  
High Fat ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose
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