Observations on the copper metabolism of the domestic fowl and duck.

1961 ◽  
Vol 12 (4) ◽  
pp. 743 ◽  
Author(s):  
AB Beck
Keyword(s):  
Copper Sulphate ◽  
Domestic Fowl ◽  
Copper Concentration ◽  
Copper Metabolism ◽  
Basal Diet ◽  
Moderate Increase ◽  
Dietary Copper ◽  
Liver Copper ◽  
Copper Storage ◽  
The Relationship

Experiments have been carried out to determine whether the concentration of copper in the liver of the domestic fowl and duck can be raised by a moderate increase of dietary copper. Groups of both species were fed for 12 weeks on the same basal diet, to which was added copper sulphate to increase the copper intake two- and fivefold. No significant increase in the liver copper concentration was noted in either species. When copper was administered to both species by intravenous injection, it was rapidly excreted. mostly in the bile. In the fowl a significant amount was excreted through the caeca, but the experiments did not suggest that these organs were important in controlling copper storage. 5tudies on the relationship between h e r copper storage and age showed that there was a rapid increase in the duck after 3 weeks of age. No such changes were observed in the foul

Supplementation of bacon pig rations by aureomycin and two levels of copper sulphate

1961 ◽  
Vol 3 (1) ◽  
pp. 89-95 ◽  
Author(s):  
D. B. Bellis
Keyword(s):  
Growth Rate ◽  
Copper Sulphate ◽  
Copper Content ◽  
Economic Advantage ◽  
Additional Benefit ◽  
Feeding Period ◽  
Food Conversion ◽  
Liver Copper ◽  
Copper Storage ◽  
Food Conversion Efficiency

A trial has been carried out to determine the effects of supplementing bacon pig diets with 125 and 250 ppm. copper (as copper sulphate) and/or aureomycin (14·4 ppm.). A total of 288 pigs were fed ad lib. from 40·100lb., and restricted-fed thereafter to bacon weight (200 1b.). Growth rate was increased by 125 ppm. copper, 250 ppm. copper, and aureomycin during the ad lib. feeding period. The magnitude of the responses was about the same in each case.During the fattening stage from 100 1b. to bacon weight, 125 ppm. copper or aureomycin increased food conversion efficiency; 250 ppm. copper however improved growth rate also. There was probably some additive effect of 125 ppm. copper and aureomycin when fed together, but it is unlikely that such an effect occurred with the higher level of copper and aureomycin.The liver copper content of pigs fed 125 ppm. copper was 3 times higher than that of the controls; 250 ppm. copper increased liver copper storage about 18·fold.The similarity in response of copper and aureomycin feeding to pigs is discussed. It is concluded that, under the conditions of the trial, their mode of action is similar. Under similar conditions in general farm practice there is unlikely to be any economic advantage in supplementing pig diets containing 250 ppm copper with aureomycin; however, the bacterial environment may sometimes be such that additional benefit will be obtained by joint supplementation.

Effect of dietary copper sulphate on the performance of growing Japanese quail

1990 ◽  
Vol 115 (2) ◽  
pp. 291-293 ◽  
Author(s):  
A. L. Yannakopoulos ◽  
A. S. Tserveni-Gousi ◽  
G. Zervas
Keyword(s):  
Japanese Quail ◽  
Copper Sulphate ◽  
Copper Concentration ◽  
Body Weight Gain ◽  
Liver Weight ◽  
Coturnix Japonica ◽  
Coturnix Coturnix Japonica ◽  
Dietary Copper ◽  
Coturnix Coturnix ◽  
Copper Supplementation

SUMMARYThe effect of 200, 400 and 600 mg dietary copper sulphate/kg was studied in 64 Japanese quail (Coturnix coturnix japonica) in 1987. The results indicated that addition of 200 or 400 mg/kg to conventional diets of quail 7–42 days old significantly increased (P < 0·05) body weight gain and significantly decreased (P < 0·05) feed intake. There were significant (P < 0·05) increases in carcass, breast and leg weights in some cases; the first two characters had the highest values in the quail fed the diet containing 200 mg Cu/kg. The addition of 600 mg Cu/kg to the diet had an adverse effect on liver weight compared with the addition of 200 and 400 mg/kg. Copper concentration in the liver was not influenced by any rate of copper supplementation.

INFLUENCE OF DIETARY COPPER, MOLYBDENUM AND SULFUR ON COPPER METABOLISM OF SHEEP

1989 ◽  
Vol 69 (1) ◽  
pp. 187-194 ◽  
Author(s):  
S. A. MOSHTAGHI-NIA ◽  
T. J. DEVLIN ◽  
G. D. PHILLIPS
Keyword(s):  
Body Weight ◽  
Copper Metabolism ◽  
Basal Diet ◽  
High Serum ◽  
Ammonium Molybdate ◽  
Dietary Copper ◽  
Serum Ceruloplasmin ◽  
Dietary Concentration ◽  
Pelleted Diet ◽  
Plot Design

Twenty-eight ram lambs were allotted to one of four treatment diets on the basis of body weight (34.7 ± 6.6 kg) in a split-plot design. The pelleted diet of alfalfa-bromegrass hay (31.2%), barley (63.2%) and molasses and premix (5.6%) was fed ad libitum and contained 11.5 mg copper (Cu), 2.8 mg molybdenum (Mo) and 1.8 g sulfur (S) kg−1 (dry matter) DM. The four experimental diets were: basal (diet I); basal plus 10 mg Mo and 2 g S (diet II); basal plus 10 mg Cu, 10 mg Mo and 2 g S (diet III); basal plus 20 mg Cu, 10 mg Mo and 2 g S (diet IV), per kilogram of diet DM. Copper as copper sulfate (CuSO4∙5H2O), S as anhydrous sodium sulfate (Na2SO4) and Mo as ammonium molybdate ((NH4)6Mo7O24∙4H2O) were added and provided Cu:Mo ratio of 5.0, 0.7, 1.5 and 2.0 for diets I, II, III and IV, respectively. Lambs were fed the experimental diets in confinement for 16 wk. Measurement of body weight and samples of liver tissue and blood serum were obtained every 4 wk. The treatment diets had no significant (P > 0.05) effect on body weight. Liver Cu concentration increased for the I and IV diets and declined for II and III diets (P < 0.01). Lambs on diet II had the highest (P < 0.01) concentration of serum total Cu, Mo and trichloroacetic acid (TCA) insoluble Cu relative to lambs consuming the other diets. Lambs assigned to diet I had higher (P < 0.01) serum ceruloplasmin (Cp) activity and TCA-soluble Cu levels than lambs consuming supplemented diets. Therefore, a dietary concentration of 3.3 g kg−1 S and Cu:Mo ratio of 0.7 caused high serum Cu and TCA-insoluble Cu which did not contribute to hepatic Cu reserves. Increasing the Cu:Mo ratio in the diet reversed these effects. Key words: Copper, molybdenum, sulfur, interaction, sheep

Hereditary Copper Toxicosis in West Highland White Terriers

1986 ◽  
Vol 23 (2) ◽  
pp. 148-154 ◽  
Author(s):  
L. P. Thornburg ◽  
D. Shaw ◽  
M. Dolan ◽  
M. Raisbeck ◽  
S. Crawford ◽  
...  
Keyword(s):  
Copper Concentration ◽  
Normal Liver ◽  
Hepatic Necrosis ◽  
Hepatic Copper ◽  
Clinically Normal ◽  
Liver Copper ◽  
Absorption Studies ◽  
The Mean ◽  
Copper Storage ◽  
High Liver

Histologic, histochemical and atomic absorption studies on liver tissue from 71 West Highland white terriers are reported. Twenty-seven dogs had histologically normal liver and copper concentration comparable to mongrel control dogs. Forty-four dogs had hepatic copper concentrations up to 22 limes the mean copper concentration found in clinically normal mongrel dogs. Hepatitis, hepatic necrosis and cirrhosis were associated with the increased copper concentration in some dogs. Matings between dogs with high liver copper concentration produced pups with high liver concentration. The copper storage defect is inherited.

Effect of ionophores on the accumulation of copper in the livers of sheep

1987 ◽  
Vol 44 (2) ◽  
pp. 255-261 ◽  
Author(s):  
J. B. J. van Ryssen ◽  
P. R. Barrowman
Keyword(s):  
Body Weight ◽  
Dry Matter ◽  
Copper Concentration ◽  
Copper Toxicity ◽  
The Other ◽  
Liver Size ◽  
Dietary Copper ◽  
Toxicity Threshold ◽  
Liver Copper ◽  
The Mean

ABSTRACTLambs were allocated to three treatments: control (C), monensin (M) and lasalocid sodium (L) in a concentrate diet containing 36 mg copper per kg food. After 2 months deaths from copper toxicity occurred and the trial was terminated. All lambs were slaughtered. The mean liver copper concentration (mg/kg dry matter) of 1907 in the M treatment was higher than the mean concentrations of 1342 and 1229 in the C and L groups respectively (P < 0·01). Total liver copper was 234, 260 and 230 mg and the retention of dietary copper in the liver was 93·5, 108·5 and 93·3 g/kg for the C, M and L treatments respectively. These differences were not significant. From reduced liver size (as a proportion of body weight) and high copper levels in the kidneys, it was concluded that the group given monensin had accumulated copper to a level closer to the toxicity threshold than the other two groups.

The copper metabolism of warm-blooded animals with special reference to the rabbit and the sheep

1963 ◽  
Vol 14 (1) ◽  
pp. 129 ◽  
Author(s):  
AB Beck
Keyword(s):  
Special Reference ◽  
Copper Metabolism ◽  
Limited Capacity ◽  
Liver Copper ◽  
Excess Copper ◽  
Real Increase ◽  
Copper Storage

Groups of rabbits were fed for 12 weeks on the same diet at two levels of copper intake (8.5 and 30 p.p.m. Cu). There was no real increase in the liver copper levels at the higher copper intake. When rabbits were injected intravenously with 1 mg Cu, the excess copper was eliminated from the liver in 96 hr. Some copper was excreted through the bile and some appears to have been excreted directly into the caecum. Experiments are described which show that, by contrast, the sheep very slowly lost excess copper from the liver. The rate of loss was the same whether the copper had been given orally or intravenously. The patterns of copper storage and excretion in warm-blooded animals are outlined, and it is postulated that the unusual copper metabolism of the sheep IS due to a limited capacity to excrete excess copper from the liver.

Studies on the assimilation and storage of copper in crossbred sheep.

1954 ◽  
Vol 5 (3) ◽  
pp. 511 ◽  
Author(s):  
AT Dick
Keyword(s):  
Copper Metabolism ◽  
Copper Accumulation ◽  
Sulphate Content ◽  
Nickel Iron ◽  
Liver Copper ◽  
Number Of Factors ◽  
Inorganic Sulphate ◽  
Copper Storage ◽  
Experimental Findings ◽  
And Storage

Experiments reported in this paper show that increased copper intake of sheep is reflected by increased copper content of the liver. The magnitude of the rise in liver copper depends upon a number of factors, but under the described conditions, the amount of copper accumulated by the animal is proportional to the copper intake within the range 3-20 mg per day; the amount stored in the liver over a 6 months1 period was found to be 4.5-5 per cent. of the intake. Some of the conditions which may modify the retention of copper were examined. It was found that the addition of ferrous sulphide to the diet, which presumably converts added copper to the insoluble sulphide, lowered the expected copper accumulation in the liver by 75 per cent. Conditions which may modify this effect of ferrous sulphide have been examined and described. Other possible sources of sulphur for the formation of copper sulphide in the animal (elemental sulphur, sodium thiosulphate) were found not to be effective. The effects of some other metals (zinc, nickel, iron, and molybdenum) on copper accumulation in the liver were examined. Molybdenum was found to have a severely limiting effect, but this effect was only observed when the diet also contained a sufficient quantity of inorganic sulphate. For a given intake of molybdenum the limitation of copper storage was found to be proportional to the sulphate content of the diet. The possible bearing of these experimental findings on conflicting field observations relating to copper metabolism of sheep is discussed.

scholarly journals The Effect of Administration of Copper Nanoparticles in Drinking Water on Redox Reactions in the Liver and Breast Muscle of Broiler Chickens

2019 ◽  
Vol 19 (3) ◽  
pp. 663-677
Author(s):  
Katarzyna Ognik ◽  
Ewelina Cholewińska ◽  
Anna Stępniowska ◽  
Aleksandra Drażbo ◽  
Krzysztof Kozłowski ◽  
...  
Keyword(s):  
Copper Nanoparticles ◽  
Copper Sulphate ◽  
Copper Content ◽  
Broiler Chickens ◽  
Dietary Supplementation ◽  
Basal Diet ◽  
Antioxidant Potential ◽  
Breast Muscle ◽  
Breast Meat ◽  
Dietary Copper

AbstractThe aim of the study was to determine what dosage of copper nanoparticles added in the form of a hydrocolloid to standard dietary supplementation with copper sulphate will increase the antioxidant potential in the liver and breast muscle of chickens. In total, 126 one-day-old Ross 308 chickens were assigned to 7 experimental groups of 18 birds each (3 replications of 6 individuals each). The basal-diet treatment did not receive nano-Cu. Experimental groups received nano-Cu (0.5, 1.0 or 1.5 mg/kg body weight per day) via a tube into the crop over three 3-day periods (days 8–10, 22–24 and 36–38) or three 7-day periods (days 8–14, 22–28 and 36–42). Dietary supplementation of chickens with nano-Cu to exceed the Cu level recommended by the NRC increased the content of Cu (P=0.042) while reducing that of Zn in the liver (P=0.031) and breast muscle (P=0.036). Supplementing the diet of chickens with nano-Cu to a level exceeding the level of copper recommended by the NRC by 7% to 25% increased the antioxidant potential of the liver and the breast meat. The study has shown that the antioxidant status of the liver and breast meat of chickens can be improved by supplementing the standard dietary copper sulphate supplement with the addition of nano-Cu, but to a level not exceeding 25% of the copper content recommended by NRC (1994) for broiler chickens, but the most safe is the nano-Cu level not exceeding 7% of the copper content recommended by NRC (1994).

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