Studies on fluorosis of sheep. 1. The toxicity of water-borne fluoride for sheep maintained in pens

1952 ◽  
Vol 3 (3) ◽  
pp. 326 ◽  
Author(s):  
AW Peirce
Keyword(s):  
Adverse Effect ◽  
Food Consumption ◽  
Dental Fluorosis ◽  
Control Group ◽  
Health Food ◽  
Adequate Diet ◽  
Cent Level ◽  
The Mean ◽  
Daily Intakes ◽  
Water Borne

Five groups, each of six sheep, were fed in pens on an adequate diet of chaffed hay and crushed grain for 3½ years. One group was given rain-water to drink, whereas the others were offered similar water to which sufficient sodium fluoride had been added to give final concentrations of 2.5, 5, 10, or 20 p.p.m. F. The mean daily intakes of fluoride, expressed as fluorine, by the four experimental groups were approximately 5, 9, 18, and 37 mg. F respectively during the winter months and 7, 13, 27, and 53 mg. F respectively during the summer months. The ingestion of fluoride appeared to have no adverse effect on general health, food consumption, or wool production. The mean weights of all groups were approximately the same throughout the experiment except at the end of 2½ years, when the weight of the group which received water containing 20 p.p.m. F was significantly less, but only at the 5 per cent. level, than that of either the control group or the groups receiving the lowest two intakes of fluoride. Mottling of the incisors and molars was only slight among the sheep which received water containing 5 p.p.m. F. It was more evident in the 10-p.p.m. group and was marked in the 20-p.p.m. group. Selective abrasion of the molars was pronounced in this last group but was also noticeable in the 10-p.p.m. group. Fluoride intake caused the incisors to erupt at an earlier age. Ingestion of fluoride brought about increases of up to twentyfold in the fluoride content of the bones and teeth. The bearing of these results on enzootic dental fluorosis among grazing sheep in Queensland is discussed.

scholarly journals The Effect of Postoperative Corticosteroid Administration on Free Vascularized Fibular Grafting for Treating Osteonecrosis of the Femoral Head

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Hao Ding ◽  
Sheng-Bao Chen ◽  
Sen Lin ◽  
You-Shui Gao ◽  
Chang-Qing Zhang
Keyword(s):  
Adverse Effect ◽  
Femoral Head ◽  
Harris Hip Score ◽  
Radiographic Evaluation ◽  
Control Group ◽  
Corticosteroid Administration ◽  
The Mean ◽  
Fibular Grafting ◽  
Free Vascularized Fibular Grafting

Free vascularized fibular grafting (FVFG) has been reported to be an effective method of treating osteonecrosis of the femoral head (ONFH). This study evaluated whether postoperative maintenance doses of corticosteroids had an adverse effect on FVFG outcomes in patients with corticosteroid-induced ONFH. We retrospectively reviewed the records of 39 patients (67 hips) who had received maintenance doses of corticosteroids following FVFG. This group was matched to a group of patients who had not received corticosteroids treatment after operation. The mean follow-up duration was 5.4 years for the postoperative corticosteroid administration group (PCA group) and 5.0 years for the control group. At the latest follow-up, the average increase in Harris hip score was 11.1 ± 8.7 points for all hips in the PCA group and 12.6 ± 7.4 points for all hips in the control group (P>0.05). In the PCA group, through radiographic evaluation, 49 hips were improved, 10 hips appeared unchanged, and 8 hips appeared worse. In the control group, 47 hips were improved, 13 hips appeared unchanged, and 7 hips appeared worse. The results suggested that postoperative maintenance doses of corticosteroids do not have an adverse effect on FVFG outcomes in patients with corticosteroid-induced ONFH.

Studies on salt tolerance of sheep. V. The tolerance of sheep for mixtures of sodium chloride, sodium carbonate, and sodium bicarbonate in the drinking water

1963 ◽  
Vol 14 (6) ◽  
pp. 815 ◽  
Author(s):  
AW Peirce
Keyword(s):  
Carbon Dioxide ◽  
Drinking Water ◽  
Sodium Chloride ◽  
Rain Water ◽  
Control Group ◽  
Health Food ◽  
Water Control ◽  
Entire Experiment ◽  
Daily Intakes ◽  
Saline Solutions

Six groups, each of six sheep, were fed in pens for 15 months on a ration of chaffed lucerne and wheaten hays. One group was offered rain-water to drink, another group was offered 1.30% sodium chloride, whereas the others were offered one of the following mixtures of sodium chloride, carbonate, and bicarbonate: 1.26 + 0.015 + 0.025, 1.21 + 0.04 + 0.06, 1.12 + 0.08 + 0.13, and 0.95 + 0.161+ 0.25%. The intake of all saline solutions was higher than that of rain-water, ranging from 150% above for 1.30% sodium chloride to 60% above for the highest level of carbonates; the mean daily intakes for the entire experiment by the six groups were 2.6, 6.6, 4.8, 5.7, 5.8, and 4.2 l. respectively. The intake also increased in all groups with temperature, being 40–70% higher in the hottest months than in the coldest months.Weight increase was less from 6 months onward in the group receiving 1.30% sodium chloride, and was less at certain times only in the experiment in the groups receiving 0.04 or 0.10% carbonates, than in that receiving rain-water (control group). There were no differences in weight increase between the control group and the groups receiving the highest concentrations (0.21 and 0.41%) of carbonates The saline drinking waters had no effect on the concentrations of sodium, potassium, calcium, magnesium, or chloride in the blood plasma. The concentration of carbon dioxide was higher, for the last year of the experiment, in the blood of the control group, and, for approximately one-third of the experiment, in that of the group receiving the highest level of carbonates in its drinking water, than in that of any of the groups receiving lower levels of carbonates. There were differences in blood carbon dioxide on one occasion only between the control group and that receiving the highest level of carbonates. None of the solutions used in the experiment had any adverse effect on the general health, food consumption or wool production of the sheep.

Studies on salt tolerance of sheep. I. The tolerance of sheep for sodium chloride in the drinking water

1957 ◽  
Vol 8 (6) ◽  
pp. 711 ◽  
Author(s):  
AW Peirce
Keyword(s):  
Drinking Water ◽  
Sodium Chloride ◽  
Chloride Concentration ◽  
Sodium Potassium ◽  
Adequate Diet ◽  
Cent Sodium ◽  
Entire Experiment ◽  
The Mean ◽  
Daily Intakes ◽  
Very High

Four groups, each of six sheep, were fed in pens for 15 months on an adequate diet of chaffed lucerne and wheaten hays. One group was offered rain-water to drink, whereas the others were offered similar water to which sufficient sodium chloride had been added to give concentrations of 1.0, 1.5, or 2.0 per cent. sodium chloride. The intake of water increased with concentration of sodium chloride, the mean daily intakes for the entire experiment being 2.0, 3.0, 4.4, and 3.0 1. for the groups whose water contained 0, 1.0, 1.5, and 2.0 per cent. sodium chloride, respectively. It also increased in all groups with temperature, being 50-70 per cent. higher in the hottest months than in the coldest months. The intake of sodium chloride by some sheep was very high; four of them consumed over 115 g (0.25 lb) daily for more than half the experiment, and 170-230 g daily for periods of 1-10 weeks. A concentration of 1.0 per cent. sodium chloride in the drinking water had no adverse effects on the sheep, but 1.5 per cent. TI-as detrimental to a small proportion and 2.0 per cent. was detrimental to all of the sheep. There was a decline in food consumption and body weight of the affected ammals, and several receiving 2.0 per cent. sodium chloride became very emaciated and weak and two were killed in extrentis. The only other obvious sign was an occasional diarrhoea which occurred in most of the sheep receiving 2.0 per cent. sodium chloride. Sodium chloride in the drinking water had no effect on the concentration of sodium, potassium, calcium, or magnesium in the blood plasma. It did, however, affect the chloride concentration; this was significantly higher, throughout the experiment, in the group which received water containing 2.0 per cent. sodium chloride.

Studies on fluorosis of sheep. II. The toxicity of water-borne fluoride for mature grazing sheep.

1954 ◽  
Vol 5 (3) ◽  
pp. 545 ◽  
Author(s):  
AW Peirce
Keyword(s):  
Adverse Effect ◽  
Body Weight ◽  
Daily Intake ◽  
The Other ◽  
Daily Consumption ◽  
Green It ◽  
Reservoir Water ◽  
Uneven Wear ◽  
Daily Intakes ◽  
Water Borne

Three groups each of 16 mature sheep were allowed to graze on sown pasture for 26 months. One group was given reservoir water, containing approximately 0.3 p.p.m. F, to drink, but the other two groups were offered similar water to which had been added sufficient sodium fluoride to give final concentrations of 10 or 20 p.p.m. F. During the winter months the treated groups drank only 0.5 1. or less of water per day and ingested virtually no fluoride. During the summer months the daily consumption of water by the groups which received 10 and 20 p.p.m. F rose to between 3 and 4 l., and the daily intake of fluoride, expressed as fluorine, to approximately 30 and 60 mg F respectively, equivalent to 0.4 and 0.8 mg F per kg body weight. The overall mean daily intakes of fluoride for the whole experiment by the two groups were 18 and 33 mg F or 0.24 and 0.44 mg F per kg body weight respectively. The ingestion of the amounts of fluoride supplied by drinking water containing as much as 20 p.p.m. F appeared to have no adverse effect on general health, body weight, or wool production of mature sheep over a period of 26 months. A brown deposit was present on the incisor teeth of all sheep throughout the experiment but was more pronounced during periods when the pasture was green; it did not appear to be related to fluoride intake, for it was as severe among the control sheep as among the treated ones. No mottling of the incisors or molars was observed, nor was there any evidence of excessive or uneven wear on these teeth. Ingestion of fluoride brought about increases up to threefold in the fluoride content of the bones and teeth.

Effect of sodium chloride on longevity in mice

1982 ◽  
Vol 243 (6) ◽  
pp. F549-F552
Author(s):  
S. M. Rosenthal
Keyword(s):  
Sodium Chloride ◽  
Food Consumption ◽  
Dietary Sodium ◽  
Control Group ◽  
Salt Loading ◽  
Extravascular Fluid ◽  
The Mean ◽  
Normotensive Strain ◽  
Dietary Sodium Chloride

The effects of dietary sodium chloride on the longevity, body weight, and food consumption in a normotensive strain (A/J) of mice was studied. Four groups of 50 mice each were fed diets containing 0.5 (control group), 1.5, 2.5, and 4.5% sodium chloride. The mean life span was 115.2 wk in the control group, and 115.5, 110,5, and 116.1 wk for groups 2, 3, and 4, with no significant differences from the control group. No differences were present in food consumption, but a graded weight loss was present after the 20th wk, which persisted throughout the experiment. No significant effect of salt loading was demonstrable on the extravascular fluid movement in either acute experiments or in the long-term dietary sodium chloride groups.

Studies on salt tolerance of sheep. IV. The tolerance of sheep for mixtures of sodium chloride and calcium chloride in the drinking water

1962 ◽  
Vol 13 (3) ◽  
pp. 479 ◽  
Author(s):  
AW Peirce
Keyword(s):  
Sodium Chloride ◽  
Calcium Chloride ◽  
Rain Water ◽  
Health Food ◽  
Drinking Waters ◽  
Entire Experiment ◽  
The Mean ◽  
Daily Intakes ◽  
Saline Solutions ◽  
Potassium Magnesium

Six groups, each of six sheep, were fed in pens for 15 months on a ration of chaffed lucerne and wheaten hays. One group was offered rain-water to drink, another group was offered 1.30% sodium chloride, whereas the others were offered one of the following mixtures of sodium and calcium chlorides: 1.24 + 0.05, 1.19 + 0.10, l.09 + 0.20, and 0.98 + 0.30%. The intake of all saline solutions was higher than that of rain-water, ranging from 100% above for 1.30% sodium chloride to 20% above for 0.30% calcium chloride; the mean daily intakes for the entire experiment by the six groups were 2.6, 5.2, 4.6, 4.4, 3.8, and 3.11, respectively. The intake also increased in all groups with temperature, being 45–60% higher in the hottest months than in the coldest months. The saline drinking waters had no effect on the concentrations of potassium, magnesium, or chloride in the blood plasma, but did result, for a considerable portion of the experiment, in lower concentrations of sodium and higher concentrations of calcium in the plasma as compared with the concentrations of these electrolytes in the plasma of sheep drinking rain-water. None of the solutions used in the experiment had any adverse effect on the general health, food consumption, weight increase, or wool production of the sheep.

Vitamin D Treatment in Patients with Hashimoto’s Thyroiditis may Decrease the Development of Hypothyroidism

2016 ◽  
Vol 86 (1-2) ◽  
pp. 9-17 ◽  
Author(s):  
Bekir Ucan ◽  
Mustafa Sahin ◽  
Muyesser Sayki Arslan ◽  
Nujen Colak Bozkurt ◽  
Muhammed Kizilgul ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hashimoto’S Thyroiditis ◽  
Healthy Control Group ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
Endocrine Society ◽  
Thyroid Autoantibody ◽  
Healthy Control ◽  
The Mean

Abstract.The relationship between Hashimoto’s thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto’s thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto’s thyroiditis and 43 healthy individuals. Vitamin D deficiency is defined as a 25-hydroxy vitamin D (25(OH)D3) concentration less than 20ng/mL. Vitamin D deficient patients were given 50.000 units of 25(OH)D3 weekly for eight weeks in accordance with the Endocrine Society guidelines. All evaluations were repeated after 2 months of treatment. Patients with Hashimoto’s thyroiditis had significantly lower vitamin D concentrations compared with the controls (9.37±0.69 ng/mL vs 11.95±1.01 ng/mL, p < 0.05, respectively). Thyroid autoantibodies were significantly decreased by vitamin D replacement treatment in patients with euthyroid Hashimoto’s thyroiditis. Also, HDL cholesterol concentrations improved in the euthyroid Hashimoto group after treatment. The mean free thyroxine (fT4) concentrations were 0.89±0.02 ng/dL in patients with Hashimoto’s thyroiditis and 1.07±0.03 ng/dL in the healthy control group (p < 0.001). The mean thyroid volumes were 7.71±0.44 mL in patients with Hashimoto’s thyroiditis and 5.46±0.63 mL in the healthy control group (p < 0.01). Vitamin D deficiency is frequent in Hashimoto’s thyroiditis and treatment of patients with this condition with Vitamin D may slow down the course of development of hypothyroidism and also decrease cardiovascular risks in these patients. Vitamin D measurement and replacement may be critical in these patients.

Mental Health Among Adolescents from Returned Portuguese Immigrant Families

2010 ◽  
Vol 69 (3) ◽  
pp. 131-139 ◽  
Author(s):  
Félix Neto
Keyword(s):  
Mental Health ◽  
Health Outcomes ◽  
Mental Health Problems ◽  
Immigrant Families ◽  
Health Problems ◽  
Mental Health Outcomes ◽  
Control Group ◽  
Older Adolescents ◽  
The Mean ◽  
Portuguese Adolescents

This study investigated mental health problems and their predictors among adolescents from returned immigrant families. The sample consisted of 360 returned adolescents (mean age = 16.8 years; SD = 1.9). The mean duration of a sojourn in Portugal for the sample was 8.2 years (SD = 4.5). A control group of 217 Portuguese youths were also included in the study. Adolescents from immigrant families reported mental health levels similar to those of Portuguese adolescents who have never migrated. Girls showed more mental health problems than boys. Younger adolescents showed fewer mental health problems than older adolescents. Adaptation variables contributed to mental health outcomes even after acculturation variables were accounted for. Implications of the study for counselors are discussed.

Rorschach Characteristics in Adolescents with Systemic Lupus Erythematosus

2006 ◽  
Vol 28 (1) ◽  
pp. 100-118 ◽  
Author(s):  
J. Santoantonio ◽  
L. Yazigi ◽  
E. I. Sato
Keyword(s):  
Lupus Erythematosus ◽  
Case Control Study ◽  
Activity Index ◽  
Disease Activity Index ◽  
Female Adolescents ◽  
Control Group ◽  
Intelligence Scale ◽  
The Mean ◽  
Experimental Group ◽  
Control Study

The purpose of this study was to investigate the personality characteristics in adolescents with SLE. The research design is a case-control study by means of the Rorschach Method and the Wechsler Intelligence Scale. Study group: 30 female adolescents with lupus, 12–17 years of age. The SLE Disease Activity Index was administered during the period of psychological evaluation. Control group: 32 nonpatient adolescents were matched for age, sex, and socioeconomic level. In the Wechsler Intelligence Scale the mean IQ of the experimental group was significantly lower than that of the control group (77 and 98, respectively, p < .001). In the Rorschach, the lupus patients showed greater difficulty in interpersonal interactions, although they displayed the resources to process affect and to cope with stressful situations. A positive moderate correlation (p = .069) between the activity index of the disease and the affect constriction proportion of the Rorschach was observed: the higher the SLEDAI score, the lower the capacity to process affect. There is a negative correlation between the activity index of the disease and the IQ (p = .001): with a higher activity index of the disease, less intellectual resources are available.

Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

1987 ◽  
Vol 57 (01) ◽  
pp. 55-58 ◽  
Author(s):  
J F Martin ◽  
T D Daniel ◽  
E A Trowbridge
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Young Males ◽  
The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

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