Access to molecular complexity. Multicomponent reactions involving five or more components.

2020 ◽  
Vol 89 (11) ◽  
pp. 1274-1336
Author(s):  
V G Nenajdenko
Keyword(s):  
Multicomponent Reactions ◽  
Molecular Complexity

scholarly journals Ultrasound-accelerated arylthiomethylation of indole via multicomponent reaction in water catalyzed by acetic acid

2017 ◽  
Vol 1 (T1) ◽  
pp. 80-85
Author(s):  
Thi Thi Xuan Luu ◽  
Vinh Quang Pham
Keyword(s):  
Acetic Acid ◽  
Multicomponent Reactions ◽  
Main Product ◽  
Step Process ◽  
Magnetic Stirring ◽  
One Step ◽  
Molecular Complexity ◽  
Activation Conditions ◽  
Reaction In Water ◽  
Moderate Yield

Multicomponent reactions (MCRs) play an important role to create the molecular complexity in a one-step process. Based on the mechanism and process of Mannich-type reactions in the synthesis of Grammin, arylthiomethylation reactions of indole were performed by using three components: indole, p-thiocresol and a solution of formaldehyde (36%) under two activation conditions, e.g. magnetic stirring and ultrasonic irradiation. The main product, 3-(p-tolylthiomethyl)-1H-indole, was obtained in a moderate yield (54%) under short irradiation (40 minutes) by probe sonicator.

Higher-order multicomponent reactions - efficient route to molecular complexity

2020 ◽  
Vol 89 ◽  
Author(s):  
Irina Valerievna Kutovaya ◽  
Valentin Georgievich Nenajdenko
Keyword(s):  
Multicomponent Reactions ◽  
Higher Order ◽  
Efficient Route ◽  
Molecular Complexity

Consecutive multicomponent reactions for the synthesis of complex molecules

2019 ◽  
Vol 17 (33) ◽  
pp. 7632-7650 ◽  
Author(s):  
Sanjun Zhi ◽  
Xiaoming Ma ◽  
Wei Zhang
Keyword(s):  
Multicomponent Reactions ◽  
Structural Diversity ◽  
Complex Molecules ◽  
Molecular Complexity ◽  
Synthetic Efficiency

Consecutive multicomponent reactions (MCRs) combine two or more MCRs to achieve high synthetic efficiency, product structural diversity, and molecular complexity.

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