Higher-order multicomponent reactions - efficient route to molecular complexity

2020 ◽  
Vol 89 ◽  
Author(s):  
Irina Valerievna Kutovaya ◽  
Valentin Georgievich Nenajdenko
Keyword(s):  
Multicomponent Reactions ◽  
Higher Order ◽  
Efficient Route ◽  
Molecular Complexity

Multicomponent reactions of amines with aldehydes and H2S as efficient route to heterocycles and thioaza macrocycles

2010 ◽  
Vol 14 (3) ◽  
pp. 463-471 ◽  
Author(s):  
V. R. Akhmetova ◽  
G. R. Khabibullina ◽  
E. B. Rakhimova ◽  
R. A. Vagapov ◽  
R. R. Khairullina ◽  
...  
Keyword(s):  
Multicomponent Reactions ◽  
Efficient Route

ChemInform Abstract: Higher-Order Multicomponent Reactions: Beyond Four Reactants

ChemInform ◽  
2013 ◽  
Vol 44 (36) ◽  
pp. no-no
Author(s):  
Sebastian Brauch ◽  
Sander S. van Berkel ◽  
Bernhard Westermann
Keyword(s):  
Multicomponent Reactions ◽  
Higher Order

scholarly journals Ultrasound-accelerated arylthiomethylation of indole via multicomponent reaction in water catalyzed by acetic acid

2017 ◽  
Vol 1 (T1) ◽  
pp. 80-85
Author(s):  
Thi Thi Xuan Luu ◽  
Vinh Quang Pham
Keyword(s):  
Acetic Acid ◽  
Multicomponent Reactions ◽  
Main Product ◽  
Step Process ◽  
Magnetic Stirring ◽  
One Step ◽  
Molecular Complexity ◽  
Activation Conditions ◽  
Reaction In Water ◽  
Moderate Yield

Multicomponent reactions (MCRs) play an important role to create the molecular complexity in a one-step process. Based on the mechanism and process of Mannich-type reactions in the synthesis of Grammin, arylthiomethylation reactions of indole were performed by using three components: indole, p-thiocresol and a solution of formaldehyde (36%) under two activation conditions, e.g. magnetic stirring and ultrasonic irradiation. The main product, 3-(p-tolylthiomethyl)-1H-indole, was obtained in a moderate yield (54%) under short irradiation (40 minutes) by probe sonicator.

scholarly journals Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

2016 ◽  
Vol 12 ◽  
pp. 1269-1301 ◽  
Author(s):  
Mohammad Haji
Keyword(s):  
Organic Compounds ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Synthetic Chemistry ◽  
Phosphonate Group ◽  
Wide Range ◽  
Efficient Route ◽  
Organophosphorus Chemistry

Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic compounds bearing a phosphonate group on the ring is given.

Consecutive multicomponent reactions for the synthesis of complex molecules

2019 ◽  
Vol 17 (33) ◽  
pp. 7632-7650 ◽  
Author(s):  
Sanjun Zhi ◽  
Xiaoming Ma ◽  
Wei Zhang
Keyword(s):  
Multicomponent Reactions ◽  
Structural Diversity ◽  
Complex Molecules ◽  
Molecular Complexity ◽  
Synthetic Efficiency

Consecutive multicomponent reactions (MCRs) combine two or more MCRs to achieve high synthetic efficiency, product structural diversity, and molecular complexity.

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