scholarly journals Ultrasound-accelerated arylthiomethylation of indole via multicomponent reaction in water catalyzed by acetic acid

2017 ◽  
Vol 1 (T1) ◽  
pp. 80-85
Author(s):  
Thi Thi Xuan Luu ◽  
Vinh Quang Pham
Keyword(s):  
Acetic Acid ◽  
Multicomponent Reactions ◽  
Main Product ◽  
Step Process ◽  
Magnetic Stirring ◽  
One Step ◽  
Molecular Complexity ◽  
Activation Conditions ◽  
Reaction In Water ◽  
Moderate Yield

Multicomponent reactions (MCRs) play an important role to create the molecular complexity in a one-step process. Based on the mechanism and process of Mannich-type reactions in the synthesis of Grammin, arylthiomethylation reactions of indole were performed by using three components: indole, p-thiocresol and a solution of formaldehyde (36%) under two activation conditions, e.g. magnetic stirring and ultrasonic irradiation. The main product, 3-(p-tolylthiomethyl)-1H-indole, was obtained in a moderate yield (54%) under short irradiation (40 minutes) by probe sonicator.

scholarly journals Naturally Inspired Pyrimidines Analogues for Alzheimer’s Disease

2020 ◽  
Vol 19 (2) ◽  
pp. 136-151
Author(s):  
Shivani Singh ◽  
Meenakshi Dhanawat ◽  
Sumeet Gupta ◽  
Deepak Kumar ◽  
Saloni Kakkar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Multicomponent Reactions ◽  
Neurodegenerative Disorder ◽  
The Body ◽  
New Drugs ◽  
Atom Economy ◽  
Step Process ◽  
One Step ◽  
Made In

: Alzheimer’s disease (AD) is a multifarious and developing neurodegenerative disorder. The treatment of AD is still a challenge and availability of drug therapy on the basis of symptoms is not up to the mark. In the context of existence, which is getting worse for the human brain, it is necessary to take care of all critical measures. The disease is caused due to multidirectional pathology of the body, which demands the multi-target-directed ligand (MTDL) approach. This gives hope for new drugs for AD, summarized here in with the pyrimidine based natural product inspired molecule as a lead. The review is sufficient in providing a list of chemical ingredients of the plant to cure AD and screen them against various potential targets of AD. The synthesis of a highly functionalized scaffold in one step in a single pot without isolating the intermediate is a challenging task. In few examples, we have highlighted the importance of this kind of reaction, generally known as multi-component reaction. Multi-component is a widely accepted technique by the drug discovery people due to its high atom economy. It reduces multi-step process to a one-step process, therefore the compounds library can be made in minimum time and cost. This review has highlighted the importance of multicomponent reactions by giving the example of active scaffolds of pyrimidine/fused pyrimidines. This would bring importance to the fast as well as smart synthesis of bio-relevant molecules.

Selective hydrodeoxygenation of tartaric acid to succinic acid

2017 ◽  
Vol 7 (21) ◽  
pp. 4944-4954 ◽  
Author(s):  
Jiayi Fu ◽  
Efterpi S. Vasiliadou ◽  
Konstantinos A. Goulas ◽  
Basudeb Saha ◽  
Dionisios G. Vlachos
Keyword(s):  
Acetic Acid ◽  
Succinic Acid ◽  
Tartaric Acid ◽  
Catalytic System ◽  
Hydrogen Atmosphere ◽  
Step Process ◽  
One Step

A novel one-step process for the selective production of succinic acid from tartaric acid is developed. High succinic yield is achieved in an efficient catalytic system comprised of MoOx/BC, HBr and acetic acid under hydrogen atmosphere.

A Facile One Step Synthesis of 3-(2-oxo-2H-chromen-3-yl)-indeno-[2,1-c]pyridazin-9-one

2005 ◽  
Vol 2005 (4) ◽  
pp. 267-269 ◽  
Author(s):  
V. Rajeswar Rao ◽  
P. Vijaya Kumar
Keyword(s):  
Acetic Acid ◽  
Hydrazine Hydrate ◽  
Single Step ◽  
Step Process ◽  
One Step

3-Acetylcoumarins (1) on reaction with ninhydrin (2) in acetic acid followed by treatment of in situ formed 2-hydroxy-2-[2-oxo-2-(2-oxo-2H-chromen-3-yl)-ethyl]indan-1,3-diones (3) with hydrazine hydrate resulted in the formation of corresponding 3-(2-oxo-2H-chromen-3-yl)-indeno[2,1-c]pyridazin-9-ones (4) in a single step with an excellent yields. The structures of newly synthesised compounds (4) were confirmed by unambiguous synthesis involving a two step process from 3-acetylcoumarins.

Functionalized aluminum-catalyzed silicon nanowire formation and radial junction photovoltaic devices

Nanoscale ◽  
2021 ◽  
Author(s):  
Wipakorn Jevasuwan ◽  
Naoki Fukata
Keyword(s):  
Surface Modification ◽  
Solar Cells ◽  
Surface Defects ◽  
Silicon Nanowire ◽  
Photovoltaic Devices ◽  
Step Process ◽  
One Step ◽  
Length Reduction

Vertical Al-catalyzed SiNW arrays with shaped surfaces were synthesized by a one-step process and NW-based solar cells were demonstrated with optimized NW surface defects through surface modification and length reduction.

scholarly journals Kinetics and Mechanism of the Change of the 4-Nitrobenzylthio-System into 4,4′-Diformylazoxybenzene in Alkaline Dioxane-Water Media

1985 ◽  
Vol 40 (11) ◽  
pp. 1128-1132
Author(s):  
Y. Riad ◽  
Adel N. Asaad ◽  
G.-A. S. Gohar ◽  
A. A. Abdallah
Keyword(s):  
Acetic Acid ◽  
Sodium Hydroxide ◽  
Rate Constants ◽  
Main Product ◽  
Reaction Medium ◽  
Aqueous Dioxane ◽  
Proton Abstraction ◽  
First Order ◽  
Water Media ◽  
Different Temperatures

Sodium hydroxide reacts with α -(4-nitrobenzylthio)-acetic acid in aqueous-dioxane media to give 4,4'-diformylazoxybenzene as the main product besides 4,4'-dicarboxyazoxybenzene and a nitrone acid. This reaction was kinetically studied in presence of excess of alkali in different dioxane-water media at different temperatures. It started by a fast reversible a-proton abstraction step followed by two consecutive irreversible first-order steps forming two intermediates (α -hydroxy, 4-nitrosobenzylthio)-acetic acid and 4-nitrosobenzaldehyde. The latter underwent a Cannizzaro's reaction, the products of which changed in the reaction medium into 4,4'-diformylazoxybenzene and 4,4'-dicarboxyazoxybenzene. The rate constants and the thermodynamic parameters of the two consecutive steps were calculated and discussed. A mechanism was put forward for the formation of the nitrone acid.Other six 4-nitrobenzyl, aryl sulphides were qualitatively studied and they gave mainly 4,4'-diformylazoxybenzene beside 4,4'-dicarboxyazoxybenzene or its corresponding azo acid.

MgO nanoparticles synthesized starting from an innovative one-step process

2017 ◽  
Vol 101 (4) ◽  
pp. 1780-1789 ◽  
Author(s):  
Giuliana Taglieri ◽  
Valeria Daniele ◽  
Claudia Mondelli
Keyword(s):  
Mgo Nanoparticles ◽  
Step Process ◽  
One Step
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