A low cost, off-the-shelf bioreactor as enabling technology for physiological modeling

2021 ◽  
Author(s):  
Muhammad Satrio Utomo ◽  
Muhammad Hanif Nadhif ◽  
Ghulsan Fahmi El Bayani ◽  
Yudan Whulanza
Keyword(s):  
Low Cost ◽  
Physiological Modeling ◽  
Enabling Technology

Role of Digital Microfluidics in Enabling Access to Laboratory Automation and Making Biology Programmable

2020 ◽  
Vol 25 (5) ◽  
pp. 411-426 ◽  
Author(s):  
Varun B. Kothamachu ◽  
Sabrina Zaini ◽  
Federico Muffatto
Keyword(s):  
Low Cost ◽  
Digital Microfluidics ◽  
Enabling Technology ◽  
Fully Integrated ◽  
Liquid Handling ◽  
Design Build ◽  
Execution Platform ◽  
Handling Technique ◽  
Screening Assays

Digital microfluidics (DMF) is a liquid handling technique that has been demonstrated to automate biological experimentation in a low-cost, rapid, and programmable manner. This review discusses the role of DMF as a “digital bioconverter”—a tool to connect the digital aspects of the design–build–learn cycle with the physical execution of experiments. Several applications are reviewed to demonstrate the utility of DMF as a digital bioconverter, namely, genetic engineering, sample preparation for sequencing and mass spectrometry, and enzyme-, immuno-, and cell-based screening assays. These applications show that DMF has great potential in the role of a centralized execution platform in a fully integrated pipeline for the production of novel organisms and biomolecules. In this paper, we discuss how the function of a DMF device within such a pipeline is highly dependent on integration with different sensing techniques and methodologies from machine learning and big data. In addition to that, we examine how the capacity of DMF can in some cases be limited by known technical and operational challenges and how consolidated efforts in overcoming these challenges will be key to the development of DMF as a major enabling technology in the computer-aided biology framework.

Feedback Delays for Ultrasensitive Sensing

2007 ◽  
Author(s):  
Mohammed F. Daqaq ◽  
Calvin Bradley ◽  
Nader Jalili ◽  
Khaled Alhazza
Keyword(s):  
Low Cost ◽  
Effective Means ◽  
Sensitivity Enhancement ◽  
Biological Species ◽  
Label Free ◽  
Enabling Technology ◽  
Shift Method ◽  
Cantilever Sensors ◽  
Magnitude Sensitivity ◽  
Frequency Variations

Nanomechanical Cantilever Sensors (NMCS) have recently emerged as an effective means for label-free chemical and biological species detection. Their high selectivity, low cost, and easy mass production make them an enabling technology for micro- and nanodetection techniques. Sensitivity constitutes one of the most desirable characteristics of NMCS. However, sensitivity of current NMCS is predominately limited by their size. In other words, smaller sensors are more sensitive than larger ones. The detection of ultra-small masses or frequency variations is therefore obstructed by the availability of more advanced fabrication techniques that are capable of manufacturing smaller and smaller sensors. Even in that case, other issues such as noise, damping, and measurement difficulties become more evident. Therefore, techniques for sensitivity enhancement should be studied and implemented to allow for accurate and precise detection of even smaller parameter variations. Along that line of reasoning, we propose a simple, but effective concept to enhance sensitivity of NMCS. The proposed methodology is based on utilizing feedback delays to create a limit-cycle response whose amplitude is ultra-sensitive to frequency variations. In this paper, we explain, analyze, and derive the equations that verify the proposed concept. We then experimentally implement the sensitivity enhancement technique on a macrocantilever beam and demonstrate more than two-orders-of-magnitude sensitivity enhancement over the frequency-shift method.

scholarly journals Multispectral Cameras and Machine Learning Integrated into Portable Devices as Clay Prediction Technology

2021 ◽  
Vol 10 (3) ◽  
pp. 40
Author(s):  
Gilson Augusto Helfer ◽  
Jorge Luis Victória Barbosa ◽  
Douglas Alves ◽  
Adilson Ben da Costa ◽  
Marko Beko ◽  
...  
Keyword(s):  
Machine Learning ◽  
Multispectral Imaging ◽  
Low Cost ◽  
Raspberry Pi ◽  
Portable Devices ◽  
Good Prediction ◽  
Enabling Technology ◽  
Fast Reaction ◽  
Strategic Information ◽  
Good Prediction Performance

The present work proposed a low-cost portable device as an enabling technology for agriculture using multispectral imaging and machine learning in soil texture. Clay is an important factor for the verification and monitoring of soil use due to its fast reaction to chemical and surface changes. The system developed uses the analysis of reflectance in wavebands for clay prediction. The selection of each wavelength is performed through an LED lamp panel. A NoIR microcamera controlled by a Raspberry Pi device is employed to acquire the image and unfold it in RGB histograms. Results showed a good prediction performance with R2 of 0.96, RMSEC of 3.66% and RMSECV of 16.87%. The high portability allows the equipment to be used in a field providing strategic information related to soil sciences.

A Preliminary Study of the Dynamic and Control of the Solar Sail

2014 ◽  
Vol 590 ◽  
pp. 371-375
Author(s):  
Ximena Celia Méndez Cubillos ◽  
Rute Cardoso Drebes
Keyword(s):  
Low Cost ◽  
Outer Space ◽  
Solar Sail ◽  
Enabling Technology ◽  
Solar Sails ◽  
Major Objective ◽  
Preliminary Study ◽  
Human Desire ◽  
The Cost ◽  
And Control

The research and curiosity about outer space had been always constant. Looking for others planets, ways, civilizations wherever the exploration of the space will be a thing which the human desire. The challenge here for several years was the obtaining energy sufficient for the application of the missions. So, presently the major objective in the missions is offer more autonomy to the spacecrafts and consequently to lower the cost of the missions. Solar Sails have long been envisaged as an enabling technology because is a promising low-cost option for space exploration for it uses for propulsion an abundant resource in space: solar radiation. In this paper a simple model of solar sail is shown and studied your performance of Control System.

scholarly journals A chip embedding solution based on low-cost plastic materials as enabling technology for smart labels

2012 ◽  
Author(s):  
Maarten Cauwe ◽  
Bjorn Vandecasteele ◽  
Johan De Baets ◽  
Jeroen van den Brand ◽  
Roel Kusters ◽  
...  
Keyword(s):  
Low Cost ◽  
Enabling Technology ◽  
Plastic Materials

scholarly journals Use, adoption and effectiveness of tippy-tap handwashing station in promoting hand hygiene practices in a resource-limited setting: A systematic review

2019 ◽  
Author(s):  
Balwani Chingatichifwe Mbakaya ◽  
Fatch W. Kalembo ◽  
Maggie Zgambo
Keyword(s):  
Systematic Review ◽  
Low Cost ◽  
Enabling Technology ◽  
Eligibility Criteria ◽  
Hygiene Practices ◽  
Resource Limited ◽  
Stomach Pain ◽  
Household Members ◽  
Limited Setting

Abstract Background A low cost and simple handwashing and enabling technology such as tippy-taps may provide adequate water sources, handwashing stations and motivation for people to prioritise handwashing. This systematic review aimed to establish the use, benefits, adoption and effectiveness of enabling technology; tippy-tap handwashing station, in resource-limited settings.Methods We systematically searched for articles in the PubMed, EMBASE, PsycINFO, AMED, CINAHL, DOAJ and Google Scholar databases using a search strategy as predefined in the protocol registered with the PROSPERO database. Data were extracted and the quality of studies was appraised by the Mixed Method Appraisal Tool.Results Twenty articles met the eligibility criteria. The use of tippy-taps for handwashing by household members or school children was reported by authors of 16 studies, and it ranged from 2.7% to 80%. The availability of tippy-taps increased handwashing and use of soap among participants. Furthermore, the majority of people who were oriented to tippy-taps or recruited to tippy-tap studies built their tippy-tap stations even after the promotional activities or programs ended. In one study, tippy-taps were found to be effective in preventing episodes of stomach pain among participants.Conclusion Tippy-tap handwashing station could help in promoting handwashing practice in resource constraint settings. Future studies are needed to evaluate the effectiveness of tippy-tap hand washing station on preventing water and hygiene-related infections.

Simulations of Impulsive Dynamics in RF MEMS Capacitive Switches

2011 ◽  
Author(s):  
Ayyaswamy Venkattraman ◽  
Alina Alexeenko
Keyword(s):  
Rf Mems ◽  
Low Cost ◽  
Enabling Technology ◽  
Capacitive Switches ◽  
Dynamic Simulations ◽  
Micro Electro Mechanical Systems ◽  
Mems Switch ◽  
Gas Damping ◽  
Power Switches ◽  
Impulsive Dynamics

Radio Frequency Micro-Electro-Mechanical Systems (RF MEMS) have emerged as a promising enabling technology for low-cost and low-power switches, actuators, and sensors. However, the reliability of these devices, especially those involving repeated contacting events, remains a major stumbling block for their widespread adaptation. In this work we present dynamic simulations of RF MEMS switch response due to electrostatic actuation in the presence of gas damping and residual stress. The dynamics emerging from the interaction between the beam structure and gas environment shows generation of stress waves induced by contact. It has been observed that these impulsive effects could lead to transient stresses that are significantly greater than the steady state bending stress. S-N curves for LIGA Nickel are used to make predictions for the lifetime at various voltages and operating gas pressures that show pressure dependence consistent with earlier experimental observations.

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