MxP+: A new dielectric etcher with enabling technology, high productivity, and low cost-of-consumables

Author(s):  
Hongching Shan
2006 ◽  
Vol 326-328 ◽  
pp. 187-190
Author(s):  
Jong Sun Kim ◽  
Chul Jin Hwang ◽  
Kyung Hwan Yoon

Recently, injection molded plastic optical products are widely used in many fields, because injection molding process has advantages of low cost and high productivity. However, there remains residual birefringence and residual stresses originated from flow history and differential cooling. The present study focused on developing a technique to measure the birefringence in transparent injection-molded optical plastic parts using two methods as follows: (i) the two colored laser method, (ii) the R-G-B separation method of white light. The main idea of both methods came from the fact that more information can be obtained from the distribution of retardation caused by different wavelengths. The comparison between two methods is demonstrated for the same sample of which retardation is up to 850 nm.


2021 ◽  
Author(s):  
Muhammad Satrio Utomo ◽  
Muhammad Hanif Nadhif ◽  
Ghulsan Fahmi El Bayani ◽  
Yudan Whulanza

2021 ◽  
Author(s):  
Benjamin Jester ◽  
Hui Zhao ◽  
Mesfin Gewe ◽  
Thomas Adame ◽  
Lisa Perruzza ◽  
...  

ABSTRACTArthrospira platensis (commonly known as spirulina) is a photosynthetic cyanobacterium1. It is a highly nutritious food that has been consumed for decades in the US, and even longer by indigenous cultures2. Its widespread use as a safe food source and proven scalability have driven frequent attempts to convert it into a biomanufacturing platform. But these were repeatedly frustrated by spirulina’s genetic intractability. We report here efficient and versatile genetic engineering methodology for spirulina that allows stable expression of bioactive protein therapeutics at high levels. We further describe large-scale, indoor cultivation and downstream processing methods appropriate for the manufacturing of biopharmaceuticals in spirulina. The potential of the platform is illustrated by pre-clinical development and human testing of an orally delivered antibody therapeutic against campylobacter, a major cause of infant mortality in the developing world and a growing antibiotic resistance threat3,4. This integrated development and manufacturing platform blends the safety of food-based biotechnology with the ease of genetic manipulation, rapid growth rates and high productivity characteristic of microbial platforms. These features combine for exceptionally low-cost production of biopharmaceuticals to address medical needs that are unfeasible with current biotechnology platforms.


Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4832
Author(s):  
Jia Wei Peng ◽  
Ho Shing Wu

In the present study, we aimed to obtain a high yield and productivity for glucosamine using a low-cost solid-state culture with Aspergillus sydowii BCRC 31742. The fermentation conditions, such as inoculum biomass, moisture content, and supplemental volume and mineral salt, were chosen to achieve high productivity of glucosamine (GlcN). When the initial supplemental volume used was 3 mL/g substrate, the yield and productivity of GlcN were 48.7 mg/gds and 0.69 mg/gds·h, respectively. This result will be helpful for the industrialization of the process.


2020 ◽  
Vol 25 (5) ◽  
pp. 411-426 ◽  
Author(s):  
Varun B. Kothamachu ◽  
Sabrina Zaini ◽  
Federico Muffatto

Digital microfluidics (DMF) is a liquid handling technique that has been demonstrated to automate biological experimentation in a low-cost, rapid, and programmable manner. This review discusses the role of DMF as a “digital bioconverter”—a tool to connect the digital aspects of the design–build–learn cycle with the physical execution of experiments. Several applications are reviewed to demonstrate the utility of DMF as a digital bioconverter, namely, genetic engineering, sample preparation for sequencing and mass spectrometry, and enzyme-, immuno-, and cell-based screening assays. These applications show that DMF has great potential in the role of a centralized execution platform in a fully integrated pipeline for the production of novel organisms and biomolecules. In this paper, we discuss how the function of a DMF device within such a pipeline is highly dependent on integration with different sensing techniques and methodologies from machine learning and big data. In addition to that, we examine how the capacity of DMF can in some cases be limited by known technical and operational challenges and how consolidated efforts in overcoming these challenges will be key to the development of DMF as a major enabling technology in the computer-aided biology framework.


Author(s):  
A. Akhtyamov ◽  
A. Ryazantsev ◽  
O. Gavrilina ◽  
A. Boyko ◽  
S. Borychev ◽  
...  

Целью исследования являлось теоретическое обоснование и практическая реализация нового способа полива гидромелиоративной машиной Фрегат с гидроприводом на сложном рельефе с минимальными затратами на модернизацию и энергозатратами. Объектом исследования является экспериментальный кранзадатчик скорости, устанавливаемый на гидромелиоративную машину. Исследования проводились в сравнении с показателями машин серийного производства. В ходе исследования было установлено, что существующая технология полива не отвечает необходимым требованиям гидромелиорации и имеет низкую степень экономической эффективности. Предлагаемая технология полива решает вопрос неравномерного распределения влаги по площади, повышает урожайность и снижает стоимость обслуживания машины вследствие уменьшения числа поломок. Имеющиеся модернизации дождевальной машины (ДМ) Фрегат , позволяющие работать по предлагаемой технологии, сложны по конструкции, ненадежны и имеют относительно высокую стоимость модернизации и сезонного обслуживания. С целью увеличения экономии средств и упрощения процесса модернизации серийных машин был разработан и протестирован кранзадатчик скорости, позволяющий снизить риск эрозии почв, застревания колес тележек и, тем самым, простой машины с необходимостью ее ремонта. Главной особенностью экспериментального краназадатчика скорости является его горизонтальное расположение относительно тележки. Два плеча с увеличенной длиной позволяют задавать поливную норму путем касания вех в начале каждого сектора, где необходимо сменить скорость движения машины. Таким образом, происходит регулирование поливной нормы, выдаваемой машиной при ее движении по орошаемой площади. Получившийся экономический эффект позволяет утверждать о положительных результатах в проведенных исследованияхThe aim of the research is the theoretical justification and practical implementation of the new method of irrigation irrigation and drainage machines Frigat with hydraulic drive for complex tasks of modernization and energy consumption. The object of the study is an experimental speedadjusting crane installed on a water reclamation machine. The studies were conducted in comparison with indicators of machine production. In the course of research it was found that the existing technology does not meet the requirements of irrigation and drainage and has a low degree of economic efficiency. The issue of uneven distribution of the owner by area, high productivity and low cost of maintenance is being addressed. DM Frigat, which allows you to work on the proposed technologies, does not require the cost of modernization and seasonal maintenance. In order to increase cost savings and develop new models of machines, a speed control crane has been developed and tested to reduce the risk of machine destruction. The operation of the trolley is the horizontal arrangement of the trolley. The speed of the machine can be increased. Thus, regulation of the irrigation rate occurs. The resulting economic effect allows us to argue about the positive results in the studies


Author(s):  
Ludmila Shvets

Defects of case details include operation of openings under bearings within 0,2 - 0,4 mm on the party, operation of landing belts under sleeves. When restoring them, traditional methods are used: installation of repair bushings, application of polymer and electrolytic coatings, micron smelting, electrospark treatment, etc. Restored parts must have hardness and wear resistance with the parameters of the material of the reducing part (deviation 10 - 15%), have sufficient adhesion to the base metal, corrosion resistance in a humid environment, provide maximum contact area with the conjugate part, no pores, slag, foreign inclusions . The method of restoration must eliminate the thermal impact on the part and be cost-effective. Polymer compositions are usually brittle, subject to breakage and leaching. Surfacing causes warping of the part, bleaching of cast iron, the formation of slag and pores in the deposited layer. The electrospark coating method does not provide sufficient contact area with the conjugate part. The use of electrolytes for iron seats in some enterprises is aggressive, unstable, requires heating or the use of expensive thyristor power supplies, followed by machining, as the microhardness of precipitation reaches a large value depending on the composition of the electrolyte and process modes, have high internal voltage. The proposed device for restoring the bearings simplifies the existing method and meets the technical requirements of manufacturers in terms of machining accuracy (ovality, taper, coaxiality and surface roughness), provides high productivity (2 times higher than the productivity of specialized machines horizontally). and low cost (60 times lower than the cost of specialized machines).


2021 ◽  
Vol 37 ◽  
pp. e37078
Author(s):  
José Vaz Pinheiro Neto

Biodiesel is a clean and cyclical energy resource that is derived from animal and/or vegetable fat. As it blends well with petrodiesel, biodiesel is added to Brazilian commercial diesel. The main raw materials used to produce biodiesel in Brazil include soybean, corn, and sunflower oils. However, these are also used for human consumption and hence, have a high market value. Therefore, pinhão manso oil, which exhibits high productivity at low cost, is a promising alternative. However, the high acidity index of this oil results in a low transesterification yield and the produced biofuel does not meet the requirements imposed by the ANP. Thus, this study intends to demonstrate that a large part of the free fatty acids in pinion oil are present in the seed endocarp. For the development of the project, the oil was extracted by hot solvent, using the soxhlet equipment and the hexane solvent, to determine the acidity index, the titration technique was used, the titrant used was sodium hydroxide. So the acidity index of the oil extracted from the seed with its shell is 10.9 mgKOH/g, while the lipid obtained without the shell exhibits a value of 0.95 mgKOH/g, proving the influence of the endocarp.


Author(s):  
Mohammed F. Daqaq ◽  
Calvin Bradley ◽  
Nader Jalili ◽  
Khaled Alhazza

Nanomechanical Cantilever Sensors (NMCS) have recently emerged as an effective means for label-free chemical and biological species detection. Their high selectivity, low cost, and easy mass production make them an enabling technology for micro- and nanodetection techniques. Sensitivity constitutes one of the most desirable characteristics of NMCS. However, sensitivity of current NMCS is predominately limited by their size. In other words, smaller sensors are more sensitive than larger ones. The detection of ultra-small masses or frequency variations is therefore obstructed by the availability of more advanced fabrication techniques that are capable of manufacturing smaller and smaller sensors. Even in that case, other issues such as noise, damping, and measurement difficulties become more evident. Therefore, techniques for sensitivity enhancement should be studied and implemented to allow for accurate and precise detection of even smaller parameter variations. Along that line of reasoning, we propose a simple, but effective concept to enhance sensitivity of NMCS. The proposed methodology is based on utilizing feedback delays to create a limit-cycle response whose amplitude is ultra-sensitive to frequency variations. In this paper, we explain, analyze, and derive the equations that verify the proposed concept. We then experimentally implement the sensitivity enhancement technique on a macrocantilever beam and demonstrate more than two-orders-of-magnitude sensitivity enhancement over the frequency-shift method.


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