scholarly journals Lipogenesis in vivo in maternal and foetal tissues during late gestation in the rat

1981 ◽  
Vol 198 (2) ◽  
pp. 425-428 ◽  
Author(s):  
M Lorenzo ◽  
T Caldés ◽  
M Benito ◽  
J M Medina
Keyword(s):  
Adipose Tissue ◽  
Plasma Insulin ◽  
Late Gestation ◽  
High Rate ◽  
Foetal Liver ◽  
Foetal Lung

The rate of 3H2O incorporation into lipid in vivo progressively decreased in liver but increased in parametrial adipose tissue during the last 3 days of gestation. These changes seem to be related to those occurring in plasma insulin and progesterone concentrations during the same period. Foetal liver showed a high rate of lipogenesis, which sharply decreased before parturition. foetal lung lipogenesis increased during days 20 and 21 of gestation.

scholarly journals Regulation of lipogenesis in vivo by glucose availability and insulin secretion in maternal and foetal tissues during late gestation in the rat. Effect of glucose intubation, streptozotocin-induced diabetes and starvation

1983 ◽  
Vol 216 (3) ◽  
pp. 695-699 ◽  
Author(s):  
M Lorenzo ◽  
M Benito ◽  
T Caldés ◽  
J M Medina
Keyword(s):  
Plasma Insulin ◽  
Late Gestation ◽  
Plasma Insulin Concentration ◽  
Maternal Liver ◽  
Foetal Liver ◽  
Streptozotocin Induced Diabetes ◽  
Chronic Hyperglycaemia ◽  
Effect Of Glucose ◽  
Glucose Availability

Administration of an oral load of glucose did not change the rate of lipogenesis in maternal liver during late gestation. However, streptozotocin-induced diabetes or starvation decreased maternal liver lipogenesis at 20-22 days of gestation. Glucose intubation, on the other hand, increased foetal lipogenesis at 21-22 days. In addition, maternal starvation decreased foetal lipogenesis and plasma insulin concentration. However, chronic hyperglycaemia induced by streptozotocin administration to the mother did not change foetal liver lipogenesis.

scholarly journals Lipid synthesis in vivo by tissues of the maternal and foetal guinea pig

1976 ◽  
Vol 154 (1) ◽  
pp. 159-161 ◽  
Author(s):  
C T Jones ◽  
W Firmin
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Guinea Pig ◽  
Lipid Synthesis ◽  
Short Chain Fatty Acids ◽  
Adipose Tissues ◽  
Pig Liver ◽  
Foetal Liver ◽  
Guinea Pig Liver

The rate of lipid biosynthesis in vivo was determined in pregnant guinea pigs after maternal and foetal injections of 3H2O. Synthesis in the maternal tissues was low and in the foetal liver and adipose tissues relatively high. In the foetal liver it reached a peak at about two-thirds of gestation, whereas that in the foetal adipose tissue occurred later. These results were used to support the view that lipid synthesis in the foetal guinea-pig liver at two-thirds of gestation is largely from short-chain fatty acids, whereas in foetal adipose tissue glucose is probably the major substrate.

scholarly journals Relationship between lipogenesis and glycogen synthesis in maternal and foetal tissues during late gestation in the rat. Effect of dexamethasone

1982 ◽  
Vol 204 (3) ◽  
pp. 865-868 ◽  
Author(s):  
M Benito ◽  
M Lorenzo ◽  
J M Medina
Keyword(s):  
Fatty Acid ◽  
Plasma Glucose ◽  
Inverse Relationship ◽  
Glycogen Synthesis ◽  
Lipid Synthesis ◽  
Blood Lipid ◽  
Late Gestation ◽  
Foetal Liver ◽  
Foetal Lung

Treatment with dexamethasone enhanced 3H2O incorporation into liver and blood lipid, and also increased plasma glucose, insulin, non-esterified fatty acid and triacylglycerol concentrations during late gestation in the mother rat. An inverse relationship between glycogen and lipid synthesis in foetal liver and lung was observed in control rats. This relationship was also observed in foetal liver, but not in foetal lung, after treatment with dexamethasone.

EFFECTS OF DEXAMETHASONE ON LIPID MOBILIZATION IN THE RAT

1970 ◽  
Vol 63 (1) ◽  
pp. 185-192 ◽  
Author(s):  
M. Krotkiewski ◽  
J. Krotkiewska ◽  
P. Björntorp
Keyword(s):  
Adipose Tissue ◽  
Plasma Insulin ◽  
Tissue Lipid ◽  
Significant Suppression ◽  
Muscle Weight ◽  
Lipid Mobilization ◽  
Injection Lipolysis ◽  
Higher Doses

ABSTRACT The effects of acute and prolonged dexamethasone administration on adipose tissue lipid metabolism were studied, by injection of dexamethasone into rats in vivo and the investigation of adipose tissue in vitro. While increasing doses of dexamethasone (evaluated 4 hours after injection) resulted in an increase of lipolysis, chronic dexamethasone administration induced significant suppression of lipolysis together with an increase in plasma insulin. When evaluated 4 hours after injection, lipolysis increase was first observed after a dose of 3μg and became progressively more marked when higher doses were used. Re-esterification however, did not contribute to the inhibition of lipid mobilization. Prolonged dexamethasone administration induced retardation of weight gain and growth, explainable at least in part by a decrease in food intake and a decrease of muscle weight, while the weight of the liver and adipose tissue was unchanged.

scholarly journals Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin

1979 ◽  
Vol 180 (3) ◽  
pp. 689-692 ◽  
Author(s):  
L Agius ◽  
A M Robinson ◽  
J R Girard ◽  
D H Williamson
Keyword(s):  
Adipose Tissue ◽  
Mammary Gland ◽  
Plasma Insulin ◽  
Regulatory Role ◽  
Maternal Liver ◽  
Peak Lactation

Removal of pups for 24 h from rats at peak lactation decreased 3H2O incorporation into lipid in vivo in mammary gland by 95%, whereas it was increased in liver (77%) and adipose tissue (330%). These increases were prevented by administration of prolactin. Plasma insulin increased 3-fold on weaning and this was partially prevented by prolactin.

scholarly journals Re-examination of the putative roles of insulin and prolactin in the regulation of lipid deposition and lipogenesis in vivo in mammary gland and white and brown adipose tissue of lactating rats and litter-removed rats

1989 ◽  
Vol 258 (1) ◽  
pp. 273-278 ◽  
Author(s):  
C M Oller do Nascimento ◽  
V Ilic ◽  
D H Williamson
Keyword(s):  
Adipose Tissue ◽  
Mammary Gland ◽  
Brown Adipose Tissue ◽  
White Adipose Tissue ◽  
Lipid Accumulation ◽  
Plasma Insulin ◽  
Fold Increase ◽  
Plasma Prolactin ◽  
Brown Adipose

1. The effects of various treatments to alter either plasma prolactin (bromocryptine administration or removal of litter) or the metabolic activity of the mammary gland (unilateral or complete teat sealing) on the disposal of oral [14C]lipid between 14CO2 production and [14C]lipid accumulation in tissues of lactating rats were studied. In addition, the rates of lipogenesis in vivo were measured in mammary gland, brown and white adipose tissue and liver. 2. Bromocryptine administration lowered plasma prolactin, but did not alter [14C]lipid accumulation in mammary gland or in white and brown adipose tissue. 3. In contrast, complete sealing of teats results in no change in plasma prolactin, but a 90% decrease in [14C]lipid accumulation in mammary gland and a 4-fold increase in white and brown adipose tissue. The rate of lipogenesis in mammary gland was decreased by 95%, but there was no change in the rate in white and brown adipose tissue. Unilateral sealing of teats resulted in a decrease in [14C]lipid accumulation in white adipose tissue. 4. Removal of the litter for 24 h (low prolactin) produced a similar pattern to complete teat sealing, except that there was a 6-fold increase in lipogenesis in white adipose tissue. Re-suckling for 5 h increased plasma prolactin, but did not alter the response seen in litter-removed lactating rats. 5. Changes in lipoprotein lipase activity and in plasma insulin paralleled the reciprocal changes in [14C]lipid accumulation in white and brown adipose tissue and in mammary gland. 6. It is concluded that the plasma insulin is more important than prolactin in regulating lipid deposition in adipose tissue during lactation, and that any effects of prolactin must be indirect.

Functional characterization of human brown adipose tissue metabolism

2020 ◽  
Vol 477 (7) ◽  
pp. 1261-1286 ◽  
Author(s):  
Marie Anne Richard ◽  
Hannah Pallubinsky ◽  
Denis P. Blondin
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Functional Characterization ◽  
Human Infants ◽  
Positron Emission ◽  
Brown Adipose ◽  
Treatment Of Obesity ◽  
And Function

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.

Estimation of the in vivo metabolic rate of adipose tissue in obese mice

2006 ◽  
Vol 31 (05) ◽  
Author(s):  
S Keipert ◽  
J Wessels ◽  
M Klingenspor ◽  
J Rozman
Keyword(s):  
Adipose Tissue ◽  
Metabolic Rate ◽  
Obese Mice

321-LB: The Link between Obesity and Changes in Epigenetic Marks in Adipose Tissue—In Vivo Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 321-LB
Author(s):  
ANETA ALAMA ◽  
DOROTA PAWE?KA ◽  
ANETA MYSZCZYSZYN ◽  
MALGORZATA MALODOBRA-MAZUR
Keyword(s):  
Adipose Tissue ◽  
In Vivo Study ◽  
Epigenetic Marks
Sign in / Sign up

Export Citation Format

Share Document