Protective Effects by Dehydroascorbic Acid through an Anti-Oxidative Pathway and Toxic Effects by Ascorbic Acid through a Hydrogen Peroxide-Dependent Pathway in Tumor Cell Lines

2018 ◽  
Author(s):  
Atsushi Satoh ◽  
Naoya Kojima ◽  
Takuya Iguchi ◽  
Kenzoh Hamada ◽  
Daiki Hasuike ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Ascorbic Acid ◽  
Tumor Cell ◽  
Cell Lines ◽  
Dehydroascorbic Acid ◽  
Toxic Effects ◽  
Protective Effects ◽  
Tumor Cell Lines ◽  
Oxidative Pathway ◽  
Dependent Pathway

The Effect of Ascorbic Acid (Vitamin C) on Two Tumor Cell Lines in Culture

Oncology ◽  
1978 ◽  
Vol 35 (4) ◽  
pp. 160-162 ◽  
Author(s):  
N. Bishun ◽  
T.K. Basu ◽  
S. Metcalfe ◽  
D.C. Williams
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines

Amifostine Does Not Inhibit the Toxic Effects of Anthracycline Derivates or Mitoxantrone on MDR Tumor Cell Lines

2001 ◽  
Vol 42 (4) ◽  
pp. 721-729 ◽  
Author(s):  
Mariagrazia Michieli ◽  
Angela Michelutti ◽  
Daniela Damiani ◽  
Anna Ermacora ◽  
Paola Masolini ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Toxic Effects ◽  
Tumor Cell Lines

Interaction of Human Tumor Cells with Human Platelets and the Coagulation System

1983 ◽  
Vol 50 (03) ◽  
pp. 726-730 ◽  
Author(s):  
Hamid Al-Mondhiry ◽  
Virginia McGarvey ◽  
Kim Leitzel
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Lines ◽  
Human Tumor ◽  
Human Platelets ◽  
Factor Vii ◽  
Coagulation System ◽  
Breast Adenocarcinoma ◽  
Activate Factor ◽  
Tumor Cell Lines

SummaryThis paper reports studies on the interaction between human platelets, the plasma coagulation system, and two human tumor cell lines grown in tissue culture: Melanoma and breast adenocarcinoma. The interaction was monitored through the use of 125I- labelled fibrinogen, which measures both thrombin activity generated by cell-plasma interaction and fibrin/fibrinogen binding to platelets and tumor cells. Each tumor cell line activates both the platelets and the coagulation system simultaneously resulting in the generation of thrombin or thrombin-like activity. The melanoma cells activate the coagulation system through “the extrinsic pathway” with a tissue factor-like effect on factor VII, but the breast tumor seems to activate factor X directly. Both tumor cell lines activate platelets to “make available” a platelet- derived procoagulant material necessary for the conversion of prothrombin to thrombin. The tumor-derived procoagulant activity and the platelet aggregating potential of cells do not seem to be inter-related, and they are not specific to malignant cells.

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