scholarly journals Physically crosslinked PVA/graphene-based materials/aloe vera hydrogel with antibacterial activity

RSC Advances ◽  
2021 ◽  
Vol 11 (46) ◽  
pp. 29029-29041
Author(s):  
Wildan Hanif ◽  
Andri Hardiansyah ◽  
Ahmad Randy ◽  
Lia A. T. W. Asri
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Aloe Vera ◽  
Freeze Thaw ◽  
3T3 Fibroblasts ◽  
Physically Crosslinked ◽  
Nih 3T3

PVA/GBM/Av hydrogels were synthesized using a freeze-thaw process. It has antibacterial activity against Staphylococcus aureus and cytocompatibility to NIH 3T3 fibroblasts, showing its potential for wound dressing application.

scholarly journals Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Marine Drugs ◽  
2021 ◽  
Vol 19 (9) ◽  
pp. 479
Author(s):  
Jingjing Zhang ◽  
Wenqiang Tan ◽  
Qing Li ◽  
Xiaorui Liu ◽  
Zhanyong Guo
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Wound Dressing ◽  
Cross Linking ◽  
And Staphylococcus Aureus ◽  
Hydrogel Films

Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.

scholarly journals A freeze–thaw PVA hydrogel loaded with guava leaf extract: physical and antibacterial properties

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 30156-30171
Author(s):  
William Xaveriano Waresindo ◽  
Halida Rahmi Luthfianti ◽  
Dhewa Edikresnha ◽  
Tri Suciati ◽  
Fatimah Arofiati Noor ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Leaf Extract ◽  
Antibacterial Properties ◽  
Freeze Thaw ◽  
Good Antibacterial Activity ◽  
Potential Applications ◽  
Guava Leaf ◽  
Pva Hydrogel

A polyvinyl alcohol (PVA) hydrogel loaded with guava leaf extract (GLE) has potential applications as a wound dressing with good antibacterial activity.

scholarly journals Antibacterial activity testing of ethanolic extract of aloe vera leaf and gel against methicillin-resistant Staphylococcus aureus

2014 ◽  
Vol 26 (2) ◽  
Author(s):  
Tias Eka Pratiwi ◽  
Warta Dewi ◽  
Eddy Prijono
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Aloe Vera ◽  
Antibacterial Properties ◽  
Ethanol Extract ◽  
Test Method ◽  
Methicillin Resistant ◽  
Aloe Vera Gel ◽  
Significant Difference

Introduction: The interest on Aloe vera based herbal products is fast growing during recent years, particularly in medication regarding their antibacterial properties which had a lot of active components such as saponin and anthraquinone. Methicillin-resistant Staphylococcus aureus has emerged as one of the most important human pathogens causing nosocomial infections and became the first priority as a consequence of their resistancy. The purpose of this study is to determine the minimum levels of ethanol extract of leaves and Aloe Vera gel that can inhibit MRSA and find out whether there are differences in antibacterial power between of ethanol extract of leaves and Aloe Vera gel. Methods: Ten isolates of MRSA were investigated for their sensitivity to Aloe vera leaf and gel extract using the serial dilution method by doing two times repetition and statistically analyzed according to t-test method. Result: The result shows that the Minimum Inhibitory Concentration of Aloe vera leaf and gel extract each located at a concentration of 25% and 12,5%. There is a significant difference in antibacterial power between the ethanol extract of leaves and Aloe Vera gel in inhibiting MRSA with MIC values of 25% and 12.5% Conclusion: There was a difference between Aloe vera leaf and gel extract antibacterial activity, where the gel extract is more effective than leaf extract.

scholarly journals Antibacterial Activity of Aloe vera Gel against Multidrug Resistant Staphylococcus aureus and Pseudomonas aeruginosa

2020 ◽  
pp. 74-80
Author(s):  
Usman A. ◽  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Wound Infection ◽  
Aloe Vera ◽  
Multidrug Resistant ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Diffusion Technique ◽  
Aloe Vera Gel

Staphylococcus aureus and Pseudomonas aeruginosa have been implicated as important nosocomial pathogens causing severe infections especially in hospitalized patients. The aim of the study was to assess the antibacterial activity of Aloe vera gel against multidrug resistant S. aureus and P. aeruginosa isolated from wound. Clinical isolates of S. aureus and P. aeruginosa from wound infection were collected from Microbiology laboratory of Barau Dikko Teaching Hospital (BDTH), Kaduna and re-confirmed using standard microbiological procedure. Antibiotic susceptibility pattern of the isolates was determined using Kirby Bauer disk diffusion method. Aloe vera gel was obtained fresh matured leaves of Aloe vera plant and was screened for the presence of phytochemical constituents. Antibacterial activity of the Aloe vera gel against Multidrug Resistant (MDR) Staphylococcus aureus and Pseudomonas aeruginosa isolates was determined by agar well diffusion technique. The result revealed that all the two isolates were resistant to more than three classes of antibiotics. The Staphylococcus aureus isolate was resistant to fluoroquinolone (ciprofloxacin), aminoglycoside (gentamicin), cephalosporin (cefaroline), folate pathway antagonist (trimethoprim-sulfamethoxazole), penicillin(cefoxitin) and macrolide (erythromycin) while the Pseudomonas aeruginosa isolate was resistant to βlactam (ticarcillin-clavulanate), fluoroquinolone (ciprofloxacin and norfloxacin), aminoglycoside (gentamicin) and cephalosporin (ceftazidime)hence regarded as MDR isolates. Phytochemical screening of the gel revealed the presence of saponins, flavonoids, terpenoids and alkaloids. The Aloe vera gel was found to have antibacterial activity against the test isolates with MIC and MBC values of 25µg/mL and 50µg/mL against MDR S. aureus 50µg/mL and 100µg/mL against MDR P. aeruginosa respectively. The study identified that Aloe vera gel possesses antibacterial activity against MDR S. aureus and P. aeruginosa isolated from wound infection. Keywords: Aloe vera gel, Staphylococcus aureus, Pseudomonas aeruginosa, antibacterial, MDR

scholarly journals Effect of Preparation Additives on the Antimicrobial Activity and Cytotoxicity of Polypyrrole

2021 ◽  
Author(s):  
Yslaine de Almeida ◽  
Diego Bispo ◽  
Monalisa Montalvão ◽  
Karina Mota ◽  
Cristiane Corrêa ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Physicochemical Characterization ◽  
Particle Morphology ◽  
Morphological Parameters ◽  
Conductive Properties ◽  
Made In

The search for new biomaterials has increased continuously in recent years and, in this context, the application of polypyrrole (PPy) as a promising material for this function has been reported as a result of positive responses, such as bioactivity and biocompatibility. In this study, PPy was obtained through modifications/adaptations made in methodologies of previous papers, which focused mainly on conductive properties. The use of additives in the synthesis significantly improves the application in the biomedical area, which depends directly on a diversity of structural and morphological parameters. Here, physicochemical characterization was helpful to determine PPy structures and morphologies of the resulting samples. The addition of phytic acid (PA) and methyl orange (MO) directly influenced not only the particle morphology and size, but also the antibacterial activity and cytotoxicity. The results of antibacterial activity against Staphylococcus aureus and Escherichia coli as well as the negligible cytotoxicity of PPy obtained here indicate a wide applicability of the materials in wound dressing and tissue engineering.

scholarly journals Formulation and Antibacterial Activity Evaluation of Quaternized Aminochitosan Membrane for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2428
Author(s):  
Ahmed M. Omer ◽  
Tamer M. Tamer ◽  
Randa E. Khalifa ◽  
Abdelazeem S. Eltaweil ◽  
Mona M. Agwa ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Surface Roughness ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Antibacterial Activities ◽  
Sample Concentration ◽  
Inhibition Concentration ◽  
Maximum Inhibition ◽  
Chitosan Biopolymer

Much attention has been paid to chitosan biopolymer for advanced wound dressing owing to its exceptional biological characteristics comprising biodegradability, biocompatibility and respectable antibacterial activity. This study intended to develop a new antibacterial membrane based on quaternized aminochitosan (QAMCS) derivative. Herein, aminochitosan (AMCS) derivative was quaternized by N-(2-Chloroethyl) dimethylamine hydrochloride with different ratios. The pre-fabricated membranes were characterized by several analysis tools. The results indicate that maximum surface potential of +42.2 mV was attained by QAMCS3 membrane compared with +33.6 mV for native AMCS membrane. Moreover, membranes displayed higher surface roughness (1.27 ± 0.24 μm) and higher water uptake value (237 ± 8%) for QAMCS3 compared with 0.81 ± 0.08 μm and 165 ± 6% for neat AMCS membranes. Furthermore, the antibacterial activities were evaluated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus cereus. Superior antibacterial activities with maximum inhibition values of 80–98% were accomplished by QAMCS3 membranes compared with 57–72% for AMCS membrane. Minimum inhibition concentration (MIC) results denote that the antibacterial activities were significantly boosted with increasing of polymeric sample concentration from 25 to 250 µg/mL. Additionally, all membranes unveiled better biocompatibility and respectable biodegradability, suggesting their possible application for advanced wound dressing.

scholarly journals AKTIVITAS ANTIBAKTERI INFUSA DAUN LIDAH BUAYA (Aloe vera L) TERHADAP PERTUMBUHAN Staphylococcus aureus DAN Escherichia coli

2019 ◽  
Vol 6 (1) ◽  
pp. 33
Author(s):  
Yuni Widyastuti ◽  
Nia Yuliani ◽  
I.G.A. Manik Widhyastini
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Aloe Vera ◽  
Bacterial Count ◽  
Inhibition Zone ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Escherichia Coli Bacteria

Antibacterial Activity of Infused Aloe Vera Leaf (Aloe Vera L) on Growth Of Stapylococcus aureus and Escherichia coliDisinfectants may act as antibacterials. Aloe vera (Aloe vera L) is one of the plants that is often used by the community as a medicinal plant that has many active compounds such as lignin, saponin and anthraquinone substances that act as antibacterial. This study aims to determine the antibacterial activity of Aloe vera leaf extracted with infusa method on the growth of Staphylococcus aureus and Escherichia coli bacteria. The research method is to see the reduction / reduction of bacterial count (% reduction) after 30 second and 60 second with disc diffusion method. The results showed decrease or decrease of bacteria count (% reduction) to Escherichia coli bacteria found in aloe leaf skin infected by 28,2% after 60 seconds. While decrease or decrease of bacteria amount (% reduction) to Staphyloccocus uareus bacteria infusa mixture of meat and skin of Aloe vera leaves of 27.5% after 60 seconds. Antibacterial test of aloe vera leaf aloe (Aloe veraL) of 100% concentration by disc diffusion method did not show any inhibition zone around cultures of test bacteria.Keywords: Aloe vera, antibacterial activity, Staphylococcus aureus, and Escherichia coli, Infusa.ABSTRAKDesinfektan dapat berfungsi sebagai antibakteri. Lidah buaya (Aloe vera L) merupakan salah satu tanaman yang sering digunakan masyarakat sebagai tanaman obat yang memiliki banyak senyawa aktif seperti lignin, saponin dan antrakuinon yaitu zat yang berfungsi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri daun lidah buaya (Aloe vera L) yang diekstrak dengan metode infusa terhadap pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli. Metode penelitian yaitu dengan melihat penurunan/pengurangan jumlah bakteri (% reduksi) setelah waktu 30 detik dan 60 detik dengan metode difusi cakram. Hasil penelitian menunjukkan penurunan atau pengurangan jumlah bakteri (% reduksi) terhadap bakteri Escherichia coli terdapat pada infusa kulit daun lidah buaya yaitu sebesar 28,2 % setelah waktu 60 detik.Sedangkan penurunan atau pengurangan jumlah bakteri (% reduksi) terhadap bakteri Staphyloccocus uareus terdapat pada infusa campuran daging dan kulit daun lidah buaya yaitu sebesar 27,5 % setelah waktu 60 detik. Uji antibakteri infusa daun lidah buaya (Aloe veraL) konsentrasi 100% dengan metode difusi cakram tidak menunjukkan adanya zona penghambatan disekitar biakan bakteri uji.Kata kunci : Lidah buaya, Aktivitas antibakteri, Staphylococcus aureus, dan   Escherichia coli,   Infusa.

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