Rational design of near-infrared fluorophores with phenolic D−A type structure and construction of a fluorescent probe for cysteine imaging

2021 ◽  
Author(s):  
Dugang Chen ◽  
Gang Nie ◽  
Yecheng Dang ◽  
Wenjie Liang ◽  
Wanqing Li ◽  
...  
Keyword(s):  
Penetration Depth ◽  
Fluorescent Probe ◽  
Fluorescent Probes ◽  
Rational Design ◽  
Near Infrared ◽  
Type Structure ◽  
Deep Penetration ◽  
Biological Applications ◽  
Low Background ◽  
Nir Emission

Fluorescent probes with near-infrared (NIR) emission have attracted great attentions in the biological applications because of the low background interference and deep penetration depth. Therefore, as an important component of...

A novel near-infrared fluorescent probe with an improved Stokes shift for specific detection of Hg2+ in mitochondria

2020 ◽  
Vol 18 (27) ◽  
pp. 5238-5244 ◽  
Author(s):  
Jin Gong ◽  
Chang Liu ◽  
Xiaojie Jiao ◽  
Song He ◽  
Liancheng Zhao ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Stokes Shift ◽  
Mitochondrial Targeting ◽  
Specific Detection ◽  
Large Stokes Shift ◽  
Nir Emission ◽  
Amine Groups

A novel mitochondrial targeting Hg2+ probe JRQNS with NIR emission (691 nm) and a large Stokes shift (78 nm) was developed by enhancing the electron donating ability of amine groups.

A visible and near-infrared dual-fluorescent probe for discrimination between Cys/Hcy and GSH and its application in bioimaging

2020 ◽  
Vol 8 (21) ◽  
pp. 5994-6003
Author(s):  
Ruixi Li ◽  
Habtamu Kassaye ◽  
Yanping Pan ◽  
Yuanzhi Shen ◽  
Weiqing Li ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Green Emission ◽  
High Sensitivity ◽  
Nir Emission ◽  
Excellent Selectivity

The probe Cy2 showed high sensitivity and excellent selectivity with a distinct fluorescence off-on response to GSH with NIR emission and Cys/Hcy with green emission, respectively.

Fluorinated near-infrared fluorescent probes for specific detection of Hg2+ in an aqueous medium and mitochondria of living cells

2017 ◽  
Vol 41 (17) ◽  
pp. 8899-8904 ◽  
Author(s):  
Lei Long ◽  
Xu Tan ◽  
Shenglin Luo ◽  
Chunmeng Shi
Keyword(s):  
Aqueous Medium ◽  
Fluorescent Probe ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Living Cells ◽  
Specific Detection

A near-infrared fluorescent probe (IR-DFT) could be used for specifically and sensitively detecting Hg2+ in mitochondria of living cells.

scholarly journals Rational design of small molecule fluorescent probes for biological applications

2020 ◽  
Vol 18 (30) ◽  
pp. 5747-5763 ◽  
Author(s):  
Joomyung V. Jun ◽  
David M. Chenoweth ◽  
E. James Petersson
Keyword(s):  
Energy Transfer ◽  
Small Molecule ◽  
Fluorescent Probes ◽  
Rational Design ◽  
Biological Systems ◽  
Biological Applications

Guidelines based on photophysical tuning, reactivity, isomerization, and energy transfer for rational design of synthetic fluorescent probes for biological systems.

scholarly journals Impact of reaction variables and PEI/l-cysteine ratio on the optical properties and cytocompatibility of cationic Ag2S quantum dots as NIR bio-imaging probes

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77644-77654 ◽  
Author(s):  
Fatma Demir Duman ◽  
Rouhullah Khodadust ◽  
Emek Goksu Durmusoglu ◽  
Mustafa Baris Yagci ◽  
Havva Yagci Acar
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Penetration Depth ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Semiconductor Quantum Dots ◽  
Imaging Probes ◽  
Bio Imaging ◽  
Ag2s Quantum Dots

Near-infrared emitting semiconductor quantum dots (NIRQDs) are popular fluorescent probes due to better penetration depth and elimination of tissue autofluorescence.

A novel near-infrared fluorescent probe with a “donor–π–acceptor” type structure and its application in the selective detection of cysteine in living cells

2019 ◽  
Vol 43 (1) ◽  
pp. 72-76 ◽  
Author(s):  
Haojia Hong ◽  
Lei Shi ◽  
Junzhe Huang ◽  
Chang Peng ◽  
Sheng Yang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Type Structure ◽  
Selective Detection

A novel “donor–π–acceptor” type fluorescent probe has been prepared for the detection of Cys. This probe shows great fluorescent performance and obvious response to Cys, and has been successfully applied in visualizing Cys in living cells.

Rational design of a fast and selective near-infrared fluorescent probe for targeted monitoring of endogenous nitric oxide

2017 ◽  
Vol 53 (76) ◽  
pp. 10520-10523 ◽  
Author(s):  
Junma Tang ◽  
Zhiqian Guo ◽  
Yutao Zhang ◽  
Bing Bai ◽  
Wei-Hong Zhu
Keyword(s):  
Nitric Oxide ◽  
Fluorescent Probe ◽  
Rational Design ◽  
Near Infrared ◽  
High Specificity ◽  
Fast Response ◽  
Turn On ◽  
Endogenous Nitric Oxide

We developed a fast and selective near-infrared (NIR) fluorescent probe for the targeted tracing of endogenous NO which possesses vital features including a significant turn-on NIR response, high specificity, and a fast response.

Rational Design of an α-Ketoamide-Based Near-Infrared Fluorescent Probe Specific for Hydrogen Peroxide in Living Systems

2016 ◽  
Vol 88 (16) ◽  
pp. 8019-8025 ◽  
Author(s):  
Xilei Xie ◽  
Xiu’e Yang ◽  
Tianhong Wu ◽  
Yong Li ◽  
Mengmeng Li ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Rational Design ◽  
Near Infrared ◽  
Living Systems

Rational design of novel near-infrared fluorescent DCM derivatives and their application in bioimaging

2016 ◽  
Vol 4 (27) ◽  
pp. 4683-4689 ◽  
Author(s):  
Xiaohang Wang ◽  
Zhiqian Guo ◽  
Shiqin Zhu ◽  
Yajing Liu ◽  
Ping Shi ◽  
...  
Keyword(s):  
Rational Design ◽  
Near Infrared ◽  
Stokes Shift ◽  
Strong Electron ◽  
Large Stokes Shift ◽  
Nir Fluorescence ◽  
Nir Emission

Tailoring the wavelength to NIR emission was realized by replacing the strong electron-withdrawing groups or extending the π-conjugated system based on the DCM chromophore, along with beneficial characteristics such as bright NIR fluorescence, large Stokes shift and low photo-bleaching.

A highly selective near infrared fluorescent probe for carboxylesterase 2 and its biological applications

2021 ◽  
Vol 9 (10) ◽  
pp. 2457-2461
Author(s):  
Xin-Yue Zhang ◽  
Tian-Tian Liu ◽  
Jia-Hao Liang ◽  
Xiang-Ge Tian ◽  
Bao-Jing Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fluorescent Probe ◽  
Side Effect ◽  
Near Infrared ◽  
Clinical Applications ◽  
Biological Applications ◽  
Key Enzyme

Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-11) in the treatment against colorectal cancer and also has some relationship with the side effect of CPT-11 in clinical applications.

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