A highly selective near infrared fluorescent probe for carboxylesterase 2 and its biological applications

2021 ◽  
Vol 9 (10) ◽  
pp. 2457-2461
Author(s):  
Xin-Yue Zhang ◽  
Tian-Tian Liu ◽  
Jia-Hao Liang ◽  
Xiang-Ge Tian ◽  
Bao-Jing Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fluorescent Probe ◽  
Side Effect ◽  
Near Infrared ◽  
Clinical Applications ◽  
Biological Applications ◽  
Key Enzyme

Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-11) in the treatment against colorectal cancer and also has some relationship with the side effect of CPT-11 in clinical applications.

Quantum dots based near-infrared fluorescent probe for the detection of PepT1 expression in colorectal cancer

2020 ◽  
Vol 739 ◽  
pp. 136977 ◽  
Author(s):  
Qi Niu ◽  
Xiyuan Yu ◽  
Qinling Yuan ◽  
Weijie Hu ◽  
Dongsheng Yu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Quantum Dots ◽  
Fluorescent Probe ◽  
Near Infrared

Rational design of near-infrared fluorophores with phenolic D−A type structure and construction of a fluorescent probe for cysteine imaging

2021 ◽  
Author(s):  
Dugang Chen ◽  
Gang Nie ◽  
Yecheng Dang ◽  
Wenjie Liang ◽  
Wanqing Li ◽  
...  
Keyword(s):  
Penetration Depth ◽  
Fluorescent Probe ◽  
Fluorescent Probes ◽  
Rational Design ◽  
Near Infrared ◽  
Type Structure ◽  
Deep Penetration ◽  
Biological Applications ◽  
Low Background ◽  
Nir Emission

Fluorescent probes with near-infrared (NIR) emission have attracted great attentions in the biological applications because of the low background interference and deep penetration depth. Therefore, as an important component of...

Detection of colorectal cancer using a small molecular fluorescent probe targeted against c-Met

Talanta ◽  
2021 ◽  
Vol 226 ◽  
pp. 122128
Author(s):  
Ji Tao ◽  
Yuanbiao Tu ◽  
Peifei Liu ◽  
Yongjia Tang ◽  
Fang Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fluorescent Probe

scholarly journals Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications

Metabolites ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 159
Author(s):  
Yao Peng ◽  
Yuqiang Nie ◽  
Jun Yu ◽  
Chi Chun Wong
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
Cancer Diagnosis ◽  
Intestinal Tract ◽  
Clinical Applications ◽  
Diagnosis And Treatment ◽  
Clinical Implications ◽  
Microbial Metabolites ◽  
Colorectal Tumorigenesis ◽  
Technology Studies

Colorectal cancer (CRC) is one of the leading cancers that cause cancer-related deaths worldwide. The gut microbiota has been proved to show relevance with colorectal tumorigenesis through microbial metabolites. By decomposing various dietary residues in the intestinal tract, gut microbiota harvest energy and produce a variety of metabolites to affect the host physiology. However, some of these metabolites are oncogenic factors for CRC. With the advent of metabolomics technology, studies profiling microbiota-derived metabolites have greatly accelerated the progress in our understanding of the host-microbiota metabolism interactions in CRC. In this review, we briefly summarize the present metabolomics techniques in microbial metabolites researches and the mechanisms of microbial metabolites in CRC pathogenesis, furthermore, we discuss the potential clinical applications of microbial metabolites in cancer diagnosis and treatment.

A novel near-infrared fluorescent probe based on isophorone for the bioassay of endogenous cysteine

2021 ◽  
Author(s):  
Hong-Bo Liu ◽  
Hai Xu ◽  
Xin Guo ◽  
Jian Xiao ◽  
Zheng-Hong Cai ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Stokes Shift ◽  
Rapid Identification ◽  
Large Stokes Shift

A near-infrared (NIR) fluorescent probe with a large Stokes shift (143 nm) for the rapid identification of Cys over Hcy and GSH in aqueous solution was developed.

A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model

2021 ◽  
Author(s):  
Bochao Chen ◽  
Shumei Mao ◽  
Yanyan Sun ◽  
Liyuan Sun ◽  
Ning Ding ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Diabetic Mouse ◽  
Living Cells ◽  
Pancreatic Tissue ◽  
Diabetic Mice ◽  
Mice Model ◽  
Viscosity Changes

A mitochondria-targeted near-infrared fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes, which was applied to detect the intracellular viscosity and imagine pancreatic tissue in diabetic mouse model.

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