scholarly journals Fabrication of self-assembled nanostructures for intracellular drug delivery from diphenylalanine analogues with rigid or flexible chemical linkers

2021 ◽  
Author(s):  
Amutha Arul ◽  
Priya Rana ◽  
Kiran Das ◽  
Ieshita Pan ◽  
Debasish Mandal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Building Blocks ◽  
Intracellular Drug Delivery ◽  
Self Assembled

Three newly synthesized building blocks, in which two FF dipeptide were connected through three different linkers, self-assemble into different super-structures with morphological individualities, considered as potential candidates for drug delivery.

scholarly journals Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1635 ◽  
Author(s):  
Hee-Jin Kim ◽  
Sungwoo Cho ◽  
Seung Joo Oh ◽  
Sung Gyu Shin ◽  
Hee Wook Ryu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Analysis ◽  
Building Blocks ◽  
The Self ◽  
Cell Therapies ◽  
Hydrophobically Modified ◽  
3D Matrix ◽  
Self Assembled ◽  
Cellular Microenvironments ◽  
Irregular Arrangement

Hydrogels incorporated with hydrophobic motifs have received considerable attention to recapitulate the cellular microenvironments, specifically for the bio-mineralization of a 3D matrix. Introduction of hydrophobic molecules into a hydrogel often results in irregular arrangement of the motifs, and further phase separation of hydrophobic domains, but limited efforts have been made to resolve this challenge in developing the hydrophobically-modified hydrogel. Therefore, this study presents an advanced integrative strategy to incorporate hydrophobic domains regularly in a hydrogel using self-assembled domains formed with polymer cross-linkers, building blocks of a hydrogel. Self-assemblies formed by polymer cross-linkers were examined as micro-domains to incorporate hydrophobic motifs in a hydrogel. The self-assembled structures in a pre-gelled solution were confirmed with the fluorescence analysis and the hydrophobicity of a hydrogel could be tuned by incorporating the hydrophobic chains in a controlled manner. Overall, the results of this study would greatly serve to tuning performance of a wide array of hydrophobically-modified hydrogels in drug delivery, cell therapies and tissue engineering.

Folate-mediated and doxorubicin-conjugated poly(ε-caprolactone)-g-chondroitin sulfate copolymers for enhanced intracellular drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59548-59557 ◽  
Author(s):  
Yu-Sheng Liu ◽  
Hsuan-Ying Chen ◽  
Jay-An Yeh ◽  
Li-Fang Wang
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Chondroitin Sulfate ◽  
Anticancer Drug ◽  
Intracellular Drug Delivery ◽  
Folate Targeting ◽  
Self Assembled

The aim of this study was to conjugate an anticancer drug, doxorubicin (DOX) and a folate targeting moiety, folic acid (FA), to self-assembled polycaprolactone (PCL)-graft-chondroitin sulfate (CS) copolymers for enhanced chemotherapy.

Self-assembled, redox-sensitive, H-shaped pegylated methotrexate conjugates with high drug-carrying capability for intracellular drug delivery

MedChemComm ◽  
2014 ◽  
Vol 5 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Haiqing Dong ◽  
Chunyan Dong ◽  
Wenjuan Xia ◽  
Yongyong Li ◽  
Tianbin Ren
Keyword(s):  
Drug Delivery ◽  
High Drug ◽  
Intracellular Drug Delivery ◽  
Self Assembled

Supramolecular association of 2D alumino-siloxane aquagel building blocks to 3D porous cages and its efficacy for topical and injectable delivery of fluconazole, an antifungal drug

2015 ◽  
Vol 3 (29) ◽  
pp. 5978-5990 ◽  
Author(s):  
Linsha Vazhayal ◽  
Nishanth Kumar Sasidharan ◽  
Sindhoor Talasila ◽  
Dileep B. S. Kumar ◽  
Ananthakumar Solaiappan
Keyword(s):  
Drug Delivery ◽  
Building Blocks ◽  
Antifungal Drug ◽  
Drug Delivery Applications ◽  
Self Assembled

A fascinating 2D architecture of an alumino-siloxane gel self-assembled into a well-defined 3D porous aquagel cage. It is identified to be an excellently mechanically stable, injectable and non-cytotoxic medium for drug delivery applications.

Bioreducible Micelles Self-Assembled from Amphiphilic Hyperbranched Multiarm Copolymer for Glutathione-Mediated Intracellular Drug Delivery

2011 ◽  
Vol 12 (5) ◽  
pp. 1567-1577 ◽  
Author(s):  
Jinyao Liu ◽  
Yan Pang ◽  
Wei Huang ◽  
Xiaohua Huang ◽  
Lili Meng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Drug Delivery ◽  
Self Assembled

Redox-responsive micelles self-assembled from dynamic covalent block copolymers for intracellular drug delivery

2015 ◽  
Vol 17 ◽  
pp. 193-200 ◽  
Author(s):  
Qinglai Yang ◽  
Lianjiang Tan ◽  
Changyu He ◽  
Bingya Liu ◽  
Yuhong Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Self Assembled

Doxorubicin Loaded Nanoparticle Consisting of Chitosan and Mannose Modified Graphene Oxide for Intracellular Drug Delivery and Anti-tumor Activity

2020 ◽  
Vol 13 (5) ◽  
pp. 5155-5164
Author(s):  
Meena K. S. ◽  
Sonia K ◽  
Alamelu Bai S
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Cancer Drug ◽  
Hemolysis Assay ◽  
Functionalized Graphene Oxide ◽  
Intracellular Drug Delivery ◽  
Modified Graphene Oxide

In order to develop the efficiency and the specificity of anticancer drug delivery, we have designed an innovative nanocarrier. The nanocarrier system comprises of a multifunctional graphene oxide nanoparticle-based drug delivery system (GO-CS-M-DOX) as a novel platform for intracellular drug delivery of doxorubicin (DOX). Firstly, graphene oxide (GO) was synthesized by hummer’s method whose surface was functionalized by chitosan (CS) in order to obtain a more precise drug delivery, the system was then decorated with mannose (M). Further conjugation of an anti-cancer drug doxorubicin to the nanocarrier system resulted in GO-CS-M-DOX drug delivery system. The resultant conjugate was characterized for its physio-chemical properties and its biocompatibility was evaluated via hemolysis assay. The drug entrapment efficiency is as high as 90% and in vitro release studies of DOX under pH 5.3 is significantly higher than that under pH 7.4. The anticancer activity of the synthesized drug delivery system was studied by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay against MCF-7 cell line. These results stated that the pH dependent multifunctional doxorubicin- chitosan functionalized graphene oxide based nanocarrier system, could lead to a promising and potential platform for intracellular delivery and cytotoxicity activity for variety of anticancer drugs.   

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