Supramolecular association of 2D alumino-siloxane aquagel building blocks to 3D porous cages and its efficacy for topical and injectable delivery of fluconazole, an antifungal drug

2015 ◽  
Vol 3 (29) ◽  
pp. 5978-5990 ◽  
Author(s):  
Linsha Vazhayal ◽  
Nishanth Kumar Sasidharan ◽  
Sindhoor Talasila ◽  
Dileep B. S. Kumar ◽  
Ananthakumar Solaiappan
Keyword(s):  
Drug Delivery ◽  
Building Blocks ◽  
Antifungal Drug ◽  
Drug Delivery Applications ◽  
Self Assembled

A fascinating 2D architecture of an alumino-siloxane gel self-assembled into a well-defined 3D porous aquagel cage. It is identified to be an excellently mechanically stable, injectable and non-cytotoxic medium for drug delivery applications.

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery

Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Sara Yazdani ◽  
Seyed Mohammad Ghoreishi ◽  
Neda Habibi
Keyword(s):  
Drug Delivery ◽  
Building Blocks ◽  
Amino Acid Sequences ◽  
Molecular Structures ◽  
Flufenamic Acid ◽  
Mixture Ratio ◽  
Drug Molecules ◽  
Release Capacity ◽  
Essential Properties ◽  
Drug Delivery Applications

Background: Due to their solid-like porous structure, molecular organogel and microcrystal structures have the capabilities of loading drug molecules, encapsulation, and extended release, all considered as essential properties in drug delivery applications. Phases of these structures, however, depend on the solvent used during the gelation process. Objective: Understanding the phase transition between organogel and microcrystal structures through adjusting the mixture ratio of different co-solvents. Method: Short peptide Diphenylalanine as the gelation building block was used due to its amino acid sequences that can be exactly selected at its molecular levels. Ethanol as a polar solvent was used in combination with four other co-solvents with different polarity levels, namely Xylene, Toluene, Acetone, and Dimethyl Sulfoxide. The morphology of molecular structures of each co-solvent combination at each ratio level was examined as well as the loading and release properties for a non-polar Flufenamic Acid drug. Results: The resultant structure wasaffected by the polarity of the co-solvents; in particular, in the sample containing 25 μg/ml of the drug, 94% of the drug amount was loaded inside the organogel. By increasing the drug concentration to 50, 75, and 100 μg/ml, the loading capability decreased to 76%, 47%, and 33%, respectively. Conclusion: Molecular organogels have excellent capabilities of loading drug molecules, while microcrystal structures have higher release capacity. The findings of this study reveal how to best design a gelation method to obtain maximum loading or release properties for a particular peptide-based drug delivery application.

Soysome: A Surfactant-Free, Fully Biobased, Self-Assembled Platform for Nanoscale Drug Delivery Applications

2018 ◽  
Vol 1 (6) ◽  
pp. 1830-1841 ◽  
Author(s):  
Ruvimbo P. Chitemere ◽  
Shane Stafslien ◽  
Bakhtiyor Rasulev ◽  
Dean C. Webster ◽  
Mohiuddin Quadir
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Applications ◽  
Self Assembled

scholarly journals Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1635 ◽  
Author(s):  
Hee-Jin Kim ◽  
Sungwoo Cho ◽  
Seung Joo Oh ◽  
Sung Gyu Shin ◽  
Hee Wook Ryu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Analysis ◽  
Building Blocks ◽  
The Self ◽  
Cell Therapies ◽  
Hydrophobically Modified ◽  
3D Matrix ◽  
Self Assembled ◽  
Cellular Microenvironments ◽  
Irregular Arrangement

Hydrogels incorporated with hydrophobic motifs have received considerable attention to recapitulate the cellular microenvironments, specifically for the bio-mineralization of a 3D matrix. Introduction of hydrophobic molecules into a hydrogel often results in irregular arrangement of the motifs, and further phase separation of hydrophobic domains, but limited efforts have been made to resolve this challenge in developing the hydrophobically-modified hydrogel. Therefore, this study presents an advanced integrative strategy to incorporate hydrophobic domains regularly in a hydrogel using self-assembled domains formed with polymer cross-linkers, building blocks of a hydrogel. Self-assemblies formed by polymer cross-linkers were examined as micro-domains to incorporate hydrophobic motifs in a hydrogel. The self-assembled structures in a pre-gelled solution were confirmed with the fluorescence analysis and the hydrophobicity of a hydrogel could be tuned by incorporating the hydrophobic chains in a controlled manner. Overall, the results of this study would greatly serve to tuning performance of a wide array of hydrophobically-modified hydrogels in drug delivery, cell therapies and tissue engineering.

Surfactant-free polymeric nanoparticles composed of PEG, cholic acid and a sucrose moiety

2014 ◽  
Vol 2 (25) ◽  
pp. 3946-3955 ◽  
Author(s):  
Carina I. C. Crucho ◽  
M. Teresa Barros
Keyword(s):  
Drug Delivery ◽  
Cholic Acid ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Building Blocks ◽  
Amphiphilic Polymers ◽  
Potential Candidate ◽  
Nanoprecipitation Method ◽  
Drug Delivery Applications

New amphiphilic polymers synthesized from a sucrose-containing conjugate exhibited interesting self-assembly properties in water. Owing to their amphiphilic characteristics polymeric nanoparticles were prepared by a nanoprecipitation method without any surfactants. These nanoparticles formulated with biocompatible building blocks can be considered a potential candidate for drug delivery applications.

scholarly journals Fabrication of self-assembled nanostructures for intracellular drug delivery from diphenylalanine analogues with rigid or flexible chemical linkers

2021 ◽  
Author(s):  
Amutha Arul ◽  
Priya Rana ◽  
Kiran Das ◽  
Ieshita Pan ◽  
Debasish Mandal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Building Blocks ◽  
Intracellular Drug Delivery ◽  
Self Assembled

Three newly synthesized building blocks, in which two FF dipeptide were connected through three different linkers, self-assemble into different super-structures with morphological individualities, considered as potential candidates for drug delivery.

scholarly journals Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications

Materials ◽  
2010 ◽  
Vol 3 (2) ◽  
pp. 1420-1460 ◽  
Author(s):  
Catarina Gonçalves ◽  
Paula Pereira ◽  
Miguel Gama
Keyword(s):  
Drug Delivery ◽  
Hydrogel Nanoparticles ◽  
Drug Delivery Applications ◽  
Self Assembled

scholarly journals Peptide Self-Assembled Nanostructures for Drug Delivery Applications

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Taotao Fan ◽  
Xiaoyan Yu ◽  
Bing Shen ◽  
Leming Sun
Keyword(s):  
Drug Delivery ◽  
Low Cost ◽  
Drug Loading ◽  
Chemical Diversity ◽  
Stimuli Responsive ◽  
Different Types ◽  
Good Biocompatibility ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Underlying Mechanisms

Peptide self-assembled nanostructures are very popular in many biomedical applications. Drug delivery is one of the most promising applications among them. The tremendous advantages for peptide self-assembled nanostructures include good biocompatibility, low cost, tunable bioactivity, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery at disease sites. Peptide self-assembled nanostructures such as nanoparticles, nanotubes, nanofibers, and hydrogels have been investigated by many researchers for drug delivery applications. In this review, the underlying mechanisms for the self-assembled nanostructures based on peptides with different types and structures are introduced and discussed. Peptide self-assembled nanostructures associated promising drug delivery applications such as anticancer drug and gene drug delivery are highlighted. Furthermore, peptide self-assembled nanostructures for targeted and stimuli responsive drug delivery applications are also reviewed and discussed.

scholarly journals Self-assembled RGD dehydropeptide hydrogels for drug delivery applications

2017 ◽  
Vol 5 (43) ◽  
pp. 8607-8617 ◽  
Author(s):  
Helena Vilaça ◽  
Tarsila Castro ◽  
Fernando M. G. Costa ◽  
Manuel Melle-Franco ◽  
Loic Hilliou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Efficient Approach ◽  
Drug Delivery Applications ◽  
Self Assembled

Combining a minimalist naproxen N-capped dehydrodipeptide hydrogelator block with a peptide bioepitope, illustrated in this work by the Npx-l-Ala-Z-ΔPhe-G-R-G-D-G-OH construct, is an efficient approach to produce functional hydrogels.

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