Folate-mediated and doxorubicin-conjugated poly(ε-caprolactone)-g-chondroitin sulfate copolymers for enhanced intracellular drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59548-59557 ◽  
Author(s):  
Yu-Sheng Liu ◽  
Hsuan-Ying Chen ◽  
Jay-An Yeh ◽  
Li-Fang Wang
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Chondroitin Sulfate ◽  
Anticancer Drug ◽  
Intracellular Drug Delivery ◽  
Folate Targeting ◽  
Self Assembled

The aim of this study was to conjugate an anticancer drug, doxorubicin (DOX) and a folate targeting moiety, folic acid (FA), to self-assembled polycaprolactone (PCL)-graft-chondroitin sulfate (CS) copolymers for enhanced chemotherapy.

scholarly journals Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal

2020 ◽  
Vol 48 (1) ◽  
pp. 1114-1124 ◽  
Author(s):  
Yan Liang ◽  
Xiaoheng Fu ◽  
Chen Du ◽  
Haoran Xia ◽  
Yusi Lai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chondroitin Sulfate ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

scholarly journals Assessment of Intracellular Delivery Potential of Novel Sustainable Poly(δ-decalactone)-Based Micelles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 726
Author(s):  
Kuldeep Kumar Bansal ◽  
Ezgi Özliseli ◽  
Gaurav Kumar Saraogi ◽  
Jessica M. Rosenholm
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Folate Receptor ◽  
In Vitro Cytotoxicity ◽  
Uptake Efficiency ◽  
Drug Delivery Carrier ◽  
Intracellular Drug Delivery ◽  
Copolymer Micelles ◽  
Model Drug

Biodegradable polymers from renewable resources have attracted much attention in recent years within the biomedical field. Lately, poly(δ-decalactone) based copolymer micelles have emerged as a potential drug delivery carrier material as a sustainable alternative to fossil-based polymers. However, their intracellular drug delivery potential is not yet investigated and therefore, in this work, we report on the synthesis and cellular uptake efficiency of poly(δ-decalactone) based micelles with or without a targeting ligand. Folic acid was chosen as a model targeting ligand and Rhodamine B as a fluorescent tracer to demonstrate the straightforward functionalisation aspect of copolymers. The synthesis of block copolymers was accomplished by a combination of facile ring-opening polymerisation and click chemistry to retain the structure uniformity. The presence of folic acid on the surface of micelles with diameter ~150 nm upsurge the uptake efficiency by 1.6 fold on folate receptor overexpressing MDA-MB-231 cells indicating the attainment of targeting using ligand functionality. The drug delivery capability of these carriers was ascertained by using docetaxel as a model drug, whereby the in vitro cytotoxicity of the drug was significantly increased after incorporation in micelles 48 h post incubation. We have also investigated the possible endocytosis route of non-targeted micelles and found that caveolae-mediated endocytosis was the preferred route of uptake. This work strengthens the prospect of using novel bio-based poly(δ-decalactone) micelles as efficient multifunctional drug delivery nanocarriers towards medical applications.

Novel self-assembled amphiphilic mPEGylated starch-deoxycholic acid polymeric micelles with pH-response for anticancer drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (98) ◽  
pp. 55139-55149 ◽  
Author(s):  
Jinlong Yang ◽  
Chunmei Gao ◽  
Shaoyu Lü ◽  
Xinggang Wang ◽  
Mingjia Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Deoxycholic Acid ◽  
Polymeric Micelles ◽  
Anticancer Drug Delivery ◽  
Ph Response ◽  
Self Assembled

scholarly journals Anticancer Drug-Phospholipid Conjugate for Enhancement of Intracellular Drug Delivery

2007 ◽  
Vol 249-250 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Taewon Hwang ◽  
Hee Dong Han ◽  
Chung Kil Song ◽  
Hasoo Seong ◽  
Jung Hyun Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Intracellular Drug Delivery

Host–guest interaction induced supramolecular amphiphilic star architecture and uniform nanovesicle formation for anticancer drug delivery

Nanoscale ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 1332-1337 ◽  
Author(s):  
Jing-ling Zhu ◽  
Kerh Li Liu ◽  
Yuting Wen ◽  
Xia Song ◽  
Jun Li
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Intracellular Drug Delivery

Star-shaped poly[(R,S)-3-hydroxybutyrate] with an α-cyclodextrin core and adamantyl end-terminals self-assembles into nanovesicle through host–guest interaction with heptakis(2,6-di-O-methyl)-β-cyclodextrin. The nanovesicle is efficient for intracellular drug delivery.

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